Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Santos, Pâmela Beatriz do Rosário Estevam dos; Lima, Patrícia Michelle Nagai de; Palma, Ana Luiza do Rosário; Hasna, Amjad Abu; Rossoni, Rodnei Dennis; Junqueira, Juliana Campos; Oliveira, Luciane Dias de

doi:10.33448/rsd-v10i1.11637

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…To illustrate a few microbial flow paths, we detected Treponema denticola, an oral bacterium commonly associated with periodontal disease, in the heart. This observation is in line with studies that have linked Treponema denticola to atherosclerosis through its invasion of aortic tissue [34][35][36] (SI Figure 5). Streptococcus pyogenes, another oral bacterium whose infection can lead to rheumatic heart disease 37 , was also detected in the heart (SI Figure 5).…”

Section: Resultssupporting

confidence: 91%

Single Cell Transcriptomics Reveals the Hidden Microbiomes of Human Tissues

Mahmoudabadi

Quake

2022

Preprint

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The human microbiome has been studied extensively across sites in the body that are readily accessible to sampling. Internal organs and tissues, however, have remained largely unexplored and, in the absence of infectious disease, are widely assumed to be free of microorganisms. Using single-cell transcriptomic data from the Tabula Sapiens spanning 15 human organ donors, 20 tissues, 400,000+ annotated cells, 100+ cell types, and ~70 billion sequences, we created an atlas of the healthy human tissue microbiome with cell type resolution. In order to construct this atlas, we developed a computational pipeline which identifies high-confidence microbial sequences from three domains of life within the sea of human transcripts in individual cells, and show that this is a non-trivial search for one in a million sequences. Together with data from a separate validation cohort of 8 additional donors, we identify more than a thousand diverse bacterial, viral and fungal species in human tissues. In characterizing the human tissue microbiome, we demonstrate that individuals harbor unique species associated not just with each tissue but often with particular cell types, and that many of these species remain uncharacterized. Moreover, combining our data with the Human Microbiome Project, the tumor microbiome dataset by Nejman et al., and the PATRIC database, we map the likely microbial flow routes from external-facing microbiomes to internal tissues and tumors, and show the existence of many unexpected routes taken by both commensals and pathogens. We find that ~30% of bacterial species found in tumors are detectable across healthy tissues, suggesting that tumor microbiomes are in part sourced from healthy tissues, even those from distant sites. Increasing the resolution of sampling from tissues to cell types, we quantify the microbial load and diversity across different cell types to reveal a network of host cell type and microbe associations. For example, we identified traces of both latent and active Epstein Barr Virus infections in various cell types such as splenic plasma cells. Broad exploration of the healthy tissue microbiome may provide insights which ultimately are of clinical importance.

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Section: Resultssupporting

confidence: 91%

Single Cell Transcriptomics Reveals the Hidden Microbiomes of Human Tissues

Mahmoudabadi

Quake

2022

Preprint

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“…T. denticola , being one of the most resistant bacteria frequently identified in primary dentition infection, is highly associated with periodontal diseases. It is commonly isolated from periodontal pockets of adults and it has great influence on the inflammation by stimulating the production of cytokines and it also causes disruption of tissue homeostasis [ 41 ]. Based on that, T. denticola is predominantly linked with severe periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Periodontal Pathogens in Slovak Patients with Periodontitis and Their Possible Aspect of Transmission from Companion Animals to Humans

Sondorová

Kučera

Kačírová

et al. 2022

Biology

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Oral health and diseases are greatly influenced by oral bacteria. During dysbiosis, bacterial composition changes, which can lead to periodontitis. Periodontitis in humans is associated with periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans. Animal-to-human transmission of some of these pathogens has also been reported. The aim of this study was to evaluate the prevalence of periodontal pathogens in Slovak patients and to assess the possible risk of transmission of these pathogens from animals to their owners. The presence of periodontal pathogens in dental plaque was monitored by PCR. Amplified products were analysed using Sanger sequencing. T. forsythia isolates were assessed for the susceptibility to different antibiotics using the disk diffusion method. In humans, T. denticola, P. gingivalis, T. forsythia and A. actinomycetemcomitans were present in 69.23%, 69.23%, 100% and 84.62%, respectively. Most isolates of T. forsythia were susceptible to amoxicillin-clavulanic acid, clindamycin and moxifloxacin, but they were resistant to metronidazole. The transmission of T. forsythia from animals to their owners was not proven based on sequence analysing. On the other hand, transmission of Porphyromonas gulae was confirmed, but the risk of its involvement in the pathogenesis of periodontitis in humans must be further investigated.

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“…Recent studies have identified significant strain variation in the biofilm formation capabilities of T. denticola . This could be partially dependent on the bacterium’s mobility, which was shown to differ greatly between strains [ 73 ].…”

Section: Periodontal Pathogens Virulence Factors and Host Responsementioning

confidence: 99%

Periodontal Pathogens and Their Links to Neuroinflammation and Neurodegeneration

2023

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Pathogens that play a role in the development and progression of periodontitis have gained significant attention due to their implications in the onset of various systemic diseases. Periodontitis is characterized as an inflammatory disease of the gingival tissue that is mainly caused by bacterial pathogens. Among them, Porphyromonas gingivalis, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia are regarded as the main periodontal pathogens. These pathogens elicit the release of cytokines, which in combination with their virulence factors induce chronic systemic inflammation and subsequently impact neural function while also altering the permeability of the blood–brain barrier. The primary objective of this review is to summarize the existing information regarding periodontal pathogens, their virulence factors, and their potential association with neuroinflammation and neurodegenerative diseases. We systematically reviewed longitudinal studies that investigated the association between periodontal disease and the onset of neurodegenerative disorders. Out of the 24 studies examined, 20 showed some degree of positive correlation between periodontal disease and neurodegenerative disorders, with studies focusing on cognitive function demonstrating the most robust effects. Therefore, periodontal pathogens might represent an exciting new approach to develop novel preventive treatments for neurodegenerative diseases.

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Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Cited by 5 publications

References 54 publications

Single Cell Transcriptomics Reveals the Hidden Microbiomes of Human Tissues

Single Cell Transcriptomics Reveals the Hidden Microbiomes of Human Tissues

Prevalence of Periodontal Pathogens in Slovak Patients with Periodontitis and Their Possible Aspect of Transmission from Companion Animals to Humans

Periodontal Pathogens and Their Links to Neuroinflammation and Neurodegeneration

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