Characterization of the trabecular rat bone mineral: effect of ovariectomy and bisphosphonate treatment

Bohic, Sylvain; Rey, Christian; Legrand, A.P.; Sfihi, H.; Rohanizadeh, Ramin; Martel, Catherine; Barbier, A.; Daculsi, Guy

doi:10.1016/s8756-3282(99)00276-8

Cited by 73 publications

(54 citation statements)

References 19 publications

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“…In a previously published study by Bohic et al, 6.5 month old rats were ovariectomized and sacrificed at 1 year post-surgery [5]. Spectral analysis comprised two parameters: the mineral-matrix ratio and the carbonate-phosphate ratio.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, implementation of FTIR in the OVX rat model has been limited, with only mineral and carbonate content reported in comparisons between healthy/osteoporotic rats [5,6]. A few studies of compositional changes in OVX rat bone have opted for implementation of alternative techniques such as Raman spectroscopy and thermogravimetric or chemical analyses [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Characterising Bone Material Composition and Structure in the Ovariectomized (OVX) Rat Model of Osteoporosis

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterising Bone Material Composition and Structure in the Ovariectomized (OVX) Rat Model of Osteoporosis

et al. 2015

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“…These species exist on trivalent anionic sites and, as in the case of carbonate, a surface location has also been identified. Hydrogen-phosphate ions have been detected using FTIR and solid-state NMR spectroscopies [22,29,[62][63][64]. The bivalent anion content, carbonate and hydrogen phosphate, of apatite is associated with a calcium and hydroxide ion deficiency.…”

Section: Main Elementsmentioning

confidence: 99%

Apatite Biominerals

2016

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Calcium phosphate apatites offer outstanding biological adaptability that can be attributed to their specific physico-chemical and structural properties. The aim of this review is to summarize and discuss the specific characteristics of calcium phosphate apatite biominerals in vertebrate hard tissues (bone, dentine and enamel). Firstly, the structural, elemental and chemical compositions of apatite biominerals will be summarized, followed by the presentation of the actual conception of the fine structure of synthetic and biological apatites, which is essentially based on the existence of a hydrated layer at the surface of the nanocrystals. The conditions of the formation of these biominerals and the hypothesis of the existence of apatite precursors will be discussed. Then, we will examine the evolution of apatite biominerals, especially during bone and enamel aging and also focus on the adaptability of apatite biominerals to the biological function of their related hard tissues. Finally, the diagenetic evolution of apatite fossils will be analyzed.

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“…To further characterize the carbonated apatite formed after cement setting and hardening, we decomposed the ν 2 CO 3 domain according to the work of Bohic and co-workers [46]. Three bands can be detected by FTIR spectroscopy at 867, 872 and 879 cm -1 which have been respectively assigned to type A carbonated apatite (carbonate ions substituted for OH ions in the hydroxyapatite structure), type B carbonated apatite (carbonate ions substituted for phosphate groups in the hydroxyapatite structure) and non-apatitic carbonate ions probably located at the surface of the crystals.…”

Section: Preparation and Characterisation Of The Cementsmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

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116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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Characterization of the trabecular rat bone mineral: effect of ovariectomy and bisphosphonate treatment

Cited by 73 publications

References 19 publications

Characterising Bone Material Composition and Structure in the Ovariectomized (OVX) Rat Model of Osteoporosis

Characterising Bone Material Composition and Structure in the Ovariectomized (OVX) Rat Model of Osteoporosis

Apatite Biominerals

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

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