Characterization of the secondary metabolites from endophytic fungi<i>Nodulisporium</i>sp. isolated from the medicinal plant<i>Mikania laevigata</i>(Asteraceae) by reversed-phase high-performance liquid chromatography coupled with mass spectrometric multistage

Reis, Isabella Mary Alves; Ribeiro, Fernanda P.C.; Almeida, Paulo Ricardo Machado de; Costa, L.C.B.; Kamida, Hélio Mitoshi; Uetanabaro, Ana Paula Trovatti; Branco, Alexsandro

doi:10.4103/pm.pm_616_17

Cited by 3 publications

(3 citation statements)

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“…Associated with the sequencing, assembly, and functional annotation of SMGCs in the genome of isolate CCMB 674, we also investigated the production of secondary metabolites (especially phenolic compounds) produced by this fungus that might play a role in plant infection and colonization using a strategy similar to that described in Abu (2017) and Reis (2018) [14,15]. Briefly, we filtrated mycelia off the liquid culture, followed by a primary extraction in methanol.…”

Section: Resultsmentioning

confidence: 99%

Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot

Quintanilha-Peixoto

Torres

Reis

et al. 2019

Toxins

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Aspergillus welwitschiae is a species of the Nigri section of the genus Aspergillus. In nature, it is usually a saprotroph, decomposing plant material. However, it causes the bole rot disease of Agave sisalana (sisal), a plant species used for the extraction of hard natural fibers, causing great economic loss to this culture. In this study, we isolated and sequenced one genome of A. welwitschiae (isolate CCMB 674 (Collection of Cultures of Microorganisms of Bahia)) from the stem tissues of sisal and performed in silico and wet lab experimental strategies to describe its ability to produce mycotoxins. CCMB 674 possesses 64 secondary metabolite gene clusters (SMGCs) and, under normal conditions, it produces secondary metabolism compounds that could disturb the cellular cycle of sisal or induce abnormalities in plant growth, such as malformin C. This isolate also produces a pigment that might explain the characteristic red color of the affected tissues. Additionally, this isolate is defective for the production of fumonisin B1, and, despite bearing the full cluster for the synthesis of this compound, it did not produce ochratoxin A. Altogether, these results provide new information on possible strategies used by the fungi during the sisal bole rot, helping to better understand this disease and how to control it.

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Section: Resultsmentioning

confidence: 99%

Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot

Quintanilha-Peixoto

Torres

Reis

et al. 2019

Toxins

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“…In Brazil, like the other South American countries, medicinal plants have been used as a traditional, cheap, and easily available alternative to drugs. Only a few tropical herbs were investigated with respect to endophytic fungal communities with bioactivity [48][49][50]. Another region of Asteraceae collection as host plants for fungal endophytes is the Panxi plateau in China [51] with xerothermic climate, diversified soil, and landscape conditions contributing to the high biodiversity in the area, concerning also medicinal plants having a long history of application by local communities [52].…”

Section: Fungal Endophytes Associated With Asteraceae-biodiversity An...mentioning

confidence: 99%

“…Anti-inflammatory, antispasmodic, antihemorrhagic, antiophidic, antiviral, antimicrobial [93] Hypoxylon Not investigated Not investigated [50] Antiparasitic, analgesic, anti-inflammatory, antitumor, antimicrobial [111] Phomopsis Antiparasitic against T. cruzi 3,4-dimethyl-2-(4 -hydroxy-3 ,5 -dimethoxyphenyl)-5methoxy-tetrahydrofuran [112] Colletotrichum Cytotoxic against leukemia tumor cells [106] Nectriapyrone, tyrosol [105] Viguiera robusta (synonym of Aldama robusta)…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Linking Endophytic Fungi to Medicinal Plants Therapeutic Activity. A Case Study on Asteraceae

et al. 2020

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Endophytes are isolated from every plant species investigated to date, so the metabolome coevolution has been affecting the plants’ (microbiota) ethnobotanic, especially therapeutic, usage. Asteraceae fulfill the rationale for plant selection to isolate endophytes since most of the species of this family have a long tradition of healing usage, confirmed by modern pharmacognosy. The present review compiles recent references on the endophyte−Asteraceae spp. interactions, targeting the secondary metabolites profile as created by both members of this biological system. Endophyte fungi associated with Asteraceae have been collected globally, however, dominant taxa that produce bioactive compounds were specific for the plant populations of different geographic origins. Endophytic fungi richness within the host plant and the biological activity were positively associated. Moreover, the pharmacological action was linked to the plant part, so differential forms of biological interactions in roots, stem, leaves, inflorescences were developed between endophytic fungi and host plants. The comparative analysis of the Asteraceae host and/or fungal endophyte therapeutic activity showed similarities that need a future explanation on the metabolome level.

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Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants

et al. 2021

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Characterization of the secondary metabolites from endophytic fungiNodulisporiumsp. isolated from the medicinal plantMikania laevigata(Asteraceae) by reversed-phase high-performance liquid chromatography coupled with mass spectrometric multistage

Cited by 3 publications

References 1 publication

Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot

Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot

Linking Endophytic Fungi to Medicinal Plants Therapeutic Activity. A Case Study on Asteraceae

Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants

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