Characterization of the regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift‐based water/fat separation

Karampinos, Dimitrios C.; Baum, Thomas; Nardo, Lorenzo; Alizai, Hamza; Yu, Hong; Carballido‐Gamio, Julio; Yap, Samuel P.; Shimakawa, Ann; Link, Thomas M.; Majumdar, Sharmila

doi:10.1002/jmri.23512

Cited by 108 publications

(107 citation statements)

References 39 publications

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“…Our data are therefore indicative of healthy aging. Second, the results of this study rely on the hypothesis that thigh muscles are homogeneous in terms of fat infiltration, which may not be the case in some disorders (for instance in type 2 diabetes (Karampinos et al 2012)). Third, the design of the study was crosssectional which limits the power of the conclusions that can be inferred due to the possible social and secular factors that might influence the direct comparison of older and young subjects.…”

Section: Discussionmentioning

confidence: 99%

NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age

Hogrel

Barnouin

Azzabou

et al. 2015

AGE

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Muscle mass is particularly relevant to follow during aging, owing to its link with physical performance and autonomy. The objectives of this work were to assess muscle volume (MV) and intramuscular fat (IMF) for all the muscles of the thigh in a large population of young and elderly healthy individuals using magnetic resonance imaging (MRI) to test the effect of gender and age on MV and IMF and to determine the best representative slice for the estimation of MV and IMF. The study enrolled 105 healthy young (range 20-30 years) and older (range 70-80 years) subjects. MRI scans were acquired along the femur length using a three-dimension three-point Dixon proton density-weighted gradient echo sequence. MV and IMF were estimated from all the slices. The effects of age and gender on MV and IMF were assessed. Predictive equations for MV and IMF were established using a single slice at various femur levels for each muscle in order to reduce the analysis process. MV was decreased with aging in both genders, particularly in the quadriceps femoris. IMF was largely increased with aging in men and, to a lesser extent, in women. Percentages of MV decrease and IMF increase with aging varied according to the muscle. Predictive equations to predict MV and IMF from single slices are provided and were validated. This study is the first one to provide muscle volume and intramuscular fat infiltration in all the muscles of the thigh in a large population of young and elderly healthy subjects.

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Section: Discussionmentioning

confidence: 99%

NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age

Hogrel

Barnouin

Azzabou

et al. 2015

AGE

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“…IMAT is found beneath the fascia of skeletal muscle (Gallagher et al, 2005) and includes adipocytes between muscle groups (intermuscular), as well as adipocytes located between muscle fibers (intramuscular) (Addison et al, 2014;Gallagher et al, 2005;Karampinos et al, 2012) (Fig. 1).…”

Section: Beyond Vat and Sat -Other White Adipose Tissue Depotsmentioning

confidence: 99%

Heterogeneity of adipose tissue in development and metabolic function

Schoettl

Fischer

Ussar

2018

Journal of Experimental Biology

163

129

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Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is compartmentalized into individual depots and distributed throughout the body. These different adipose depots show major functional differences and risk associations for developing metabolic syndrome. Recent advances in lineage tracing demonstrate that individual adipose depots are composed of adipocytes that are derived from distinct precursor populations, giving rise to different populations of energy-storing white adipocytes. Moreover, distinct lineages of energy-dissipating brown and beige adipocytes exist in discrete depots or within white adipose tissue depots. In this Review, we discuss developmental and functional heterogeneity, as well as sexual dimorphism, between and within individual adipose tissue depots. We highlight current data relating to the differences between subcutaneous and visceral white adipose tissue in the development of metabolic dysfunction, with special emphasis on adipose tissue expansion and remodeling of the extracellular matrix. Moreover, we provide a detailed overview of adipose tissue development as well as the consensus and controversies relating to adult adipocyte precursor populations.

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“…In this fatty depot, lipids are stored as adipocytes located between and within individual skeletal muscle groups (interand intramuscular fat, respectively), or as fat droplets within the muscle cells' cytoplasm (intramyocellular lipids (IMCL)). The fat concentration varies greatly over the compartment (4,8,9), and fat concentrations below 0.5 % may be expected in some muscle groups (10).…”

Section: Fat Quantification In Skeletal Muscle Using Multigradient-ecmentioning

confidence: 99%

“…Water/fat imaging has also shown potential in vitro to accurately measure FFs below 1 % (19,22), and has recently been used for measurements of muscular fat in vivo (4,23).…”

Section: Fat Quantification In Skeletal Muscle Using Multigradient-ecmentioning

confidence: 99%

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

Peterson

Romu

Brorson

et al. 2015

J. Magn. Reson. Imaging

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Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal 1 Fat quantification in skeletal muscleFat quantification in skeletal muscle using multigradient-echo imaging: comparison of fat and water references 2 Fat quantification in skeletal muscle AbstractPurpose: To compare the precision, accuracy, and repeatability of water/fat imaging-based fat quantification in muscle tissue using small or large flip angles (FAs), and a water or fat reference for calculation of the proton density fat fraction (FF). Materials and methods:An Intralipid phantom and both forearms of six patients suffering from lymphedema and ten healthy volunteers were investigated in a 1.5T scanner. Two multigradient-echo sequences with eight echo times and FAs of 10° and 85° were acquired, respectively. For healthy volunteers, the acquisition of the right arm was performed twice with repositioning. From each set, water reference FF and fat reference FF images were reconstructed and the average FF and the standard deviation were calculated within the subfascial compartment. The small FA water reference was considered the reference standard.Results: The use of a fat reference effectively avoided bias due to T 1 weighting when using a large FA. The large FA fat reference approach also resulted in the highest precision, but no significant difference in repeatability between the various methods was detected. Conclusion:The precision of fat quantification in muscle tissue can be increased with maintained accuracy using a larger flip angle, if a fat reference instead of a water reference is used.

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Characterization of the regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift‐based water/fat separation

Cited by 108 publications

References 39 publications

NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age

NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age

Heterogeneity of adipose tissue in development and metabolic function

Fat quantification in skeletal muscle using multigradient-echo imaging: Comparison of fat and water references

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