Characterization of the rat exploratory behavior in the elevated plus-maze with Markov chains

Investigation of rat exploratory behavior via evolving artificial neural networks

“…Some studies have shown that, after this period, rat's interest in the maze is naturally decreased (Montgomery, 1955). M a n u s c r i p t for the investigation of the behavior of rats in the EPM (Salum et al, 2000;Giddings, 2002;Miranda et al, 2009;Shimo et al, 2010;Tejada et al, 2010;Costa et al, 2012Costa et al, , 2013. One of the advantages of computational models is their ability to predict real phenomena.…”

“…In this way, it can reduce the number of experiments with real rats, which implies less suffering and death for those animals. To the best of the authors knowledge, just two of the models proposed in the literature do not use ANNs; instead, they use Markov models to compute different probabilities for transitions of the artificial agent in different maze positions 2 (Giddings, 2002;Tejada et al, 2010).…”

A novel anxiety index for the rat behavior in the elevated plus-maze

“…transitions between connected nodes can occur in both directions. Using the directed graph representation we have shown that the displacements of the rat in the EPM during a 5 min trial can be well modeled by a first-order homogeneous Markov chain [4]. Moreover, we have shown that the estimated stochastic matrix, which gives the transition probabilities between nodes, is sensitive to the pharmacological condition of the animal, i.e.…”

“…Moreover, we have shown that the estimated stochastic matrix, which gives the transition probabilities between nodes, is sensitive to the pharmacological condition of the animal, i.e. if it belongs to the control group or was treated with an anxiogenic or anxiolytic drug [4]. The stochastic matrices for the different drug treatment types are interesting to compare different groups of rats but they are not practical as succinct indexes of their anxiety level.…”

Investigação de modelos comportamentais de ratos por meio de algoritmos genéticos

“…Curiosamente, dentre todos os trabalhos publicados envolvendo ratos no LCE, apenas nove exploraram modelos computacionais, de acordo com o conhecimento da autora [18,19,20,21,22,23,24,25,26] [67]. Os elementos que atuam na população, por exemplo selecionando-a ou modificando-a, são chamados de operadores.…”