Characterization of the preferred orientation of δ-mannitol crystallites in tablets

Koivisto, Mikko; Virjonen, Tero; Heikkilä, Teemu; Lehto, Vesa‐Pekka

doi:10.1016/j.jpba.2004.07.019

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…Texture is especially likely to have an effect on the diffractograms of the sample when the crystallites are needle or plate-like. A short review of studies on texture and its effects in the field of pharmaceutical sciences has recently been reported [2]. The effects of preferred orientation in X-ray diffraction studies are described in a review by Stephenson et al [3].…”

Section: Introductionmentioning

confidence: 99%

“…The effects of preferred orientation in X-ray diffraction studies are described in a review by Stephenson et al [3]. It has been previously reported that texturization often takes place when the powder sample is compacted to form a tablet [2,4,5]. Previous results have shown that the degree of texture in tablets is correlated with the compaction properties of the sample [4].…”

Section: Introductionmentioning

confidence: 99%

“…This study had three main purposes: (1) to compare three different methods for determining texture, (2) to study the texturization of some unground and ground APIs, and (3) to examine the effect of preferred orientation on the IDR using compacted discs. To the best of our knowledge, there has to this date been no previous demonstration of any correlation between the sample texture and the intrinsic dissolution rate.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution?

Tenho¹,

Heinänen²,

Tanninen³

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution?

Tenho¹,

Heinänen²,

Tanninen³

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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“…23 For the GCC ͑202͒ and PCC ͑132͒ peaks, the corrections for the intensity diffracted from the steel sample holder ͑111͒ planes, accounting for absorption by the sample, were made using a similar principle. First it was assumed that the shape of the ⌿ profile of the background intensity remains the same at a small section of the diffraction angle 2.…”

Section: B Measurement Methodsmentioning

confidence: 99%

X-ray texture analysis of paper coating pigments and the correlation with chemical composition analysis

Roine

Tenho

Murtomaa

et al. 2007

Journal of Applied Physics

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The present research experiments the applicability of x-ray texture analysis in investigating the properties of paper coatings. The preferred orientations of kaolin, talc, ground calcium carbonate, and precipitated calcium carbonate particles used in four different paper coatings were determined qualitatively based on the measured crystal orientation data. The extent of the orientation, namely, the degree of the texture of each pigment, was characterized quantitatively using a single parameter. As a result, the effect of paper calendering is clearly seen as an increase on the degree of texture of the coating pigments. The effect of calendering on the preferred orientation of kaolin was also evident in an independent energy dispersive spectrometer analysis on micrometer scale and an electron spectroscopy for chemical analysis on nanometer scale. Thus, the present work proves x-ray texture analysis to be a potential research tool for characterizing the properties of paper coating layers.

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“…Texture has not been widely studied in the field of pharmaceutical materials research (Koivisto et al, 2004). However, it has been suggested and also reported that texturization will affect the compaction behaviour and other mechanical properties of pharmaceutical tablets (Koivisto et al, 2004(Koivisto et al, , 2006. A weak correlation between the texture and intrinsic dissolution rate (IDR) of some active pharmaceutical ingredients has recently been reported (Tenho et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of texture on the intrinsic dissolution behaviour of acetylsalicylic acid and tolbutamide compacts

et al. 2007

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Preferred orientation of crystallites, i.e. texture, is a common result when a sample with an irregular habit of particles is compacted to form a tablet. Since texturization alters the random distribution of the crystal planes on the surface of the compacted sample, the dissolution properties of highly texturized tablets could differ from the properties of a tablet with a less preferred orientation. Three batches from both acetylsalicylic acid and tolbutamide were recrystallized using different crystallization parameters to obtain powders with different texturization behaviour. Several X-ray diffraction procedures were used to characterize the texture and other crystallographic properties of the samples. The intrinsic dissolution profiles were measured using the channel flow technique. In addition, the attachment energy of the crystal planes lying on the surface of the compacts was calculated theoretically. The results indicate that the most texturized compacts had a clearly lower intrinsic dissolution rate than the compacts with a lower degree of preferred orientation. By combining the results of the texture measurements with the calculated attachment energy values, the surface energies of the samples could be estimated and the estimated energy values were in agreement with the results of the dissolution studies. Moreover, it was found that by using the results of the texture measurements, the habit of the sample particles can be successfully predicted.

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Characterization of the preferred orientation of δ-mannitol crystallites in tablets

Cited by 7 publications

References 14 publications

Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution?

Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution?

X-ray texture analysis of paper coating pigments and the correlation with chemical composition analysis

Effect of texture on the intrinsic dissolution behaviour of acetylsalicylic acid and tolbutamide compacts

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