Does the preferred orientation of crystallites in tablets affect the intrinsic dissolution?

Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid

“…However, since the conversion of CBZ was very slow, no remarkable phase changes were probably induced between the sampling and the X‐ray measurement. The peak intensity comparison was complicated by the significant preferred orientation effect,26 which indicated that specific planes were more preferred in the studied crystals than the planes in typical randomly orientated CBZ dihydrate crystals. Based on the solved crystal structure of CBZ dihydrate, the most texturized plane in SIF [corresponding to the intense peak at 12.3° (2 θ )] was the plane (0 2 0).…”

Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds

“…5b). Because cocrystals transform to host crystals, accurate evaluations are difficult (39). However, the initial dissolution rate of MA was improved by cocrystallization with SA.…”

Effect of texture on the intrinsic dissolution behaviour of acetylsalicylic acid and tolbutamide compacts

“…Our previous study concluded that preferred orientation does not affect the IDR to a great extent (Tenho et al, 2007). However, in that study the tablets with a low degree of preferred orientation were made from the ground powder.…”

“…However, it has been suggested and also reported that texturization will affect the compaction behaviour and other mechanical properties of pharmaceutical tablets (Koivisto et al, 2004(Koivisto et al, , 2006. A weak correlation between the texture and intrinsic dissolution rate (IDR) of some active pharmaceutical ingredients has recently been reported (Tenho et al, 2007).…”