Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: Genomic, mRNA, and protein sequences with comparisons to other species

Januzzi, James L.; Azrolan, Neal; O'Connell, Anita; Aalto‐Setälä, Katriina; Breslow, Jan L.

doi:10.1016/s0888-7543(05)80133-8

Cited by 36 publications

(15 citation statements)

References 26 publications

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“…The apoA-I promoter sequence contains motifs for peroxisome proliferator-activated receptor-a (PPAR-a) (27). We and others have shown that PPAR-a ligands, including oxidized fatty acids, induce the expression of apoA-I (28, 29) in cultured cells.…”

Section: Resultsmentioning

confidence: 99%

Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin

Jaichander

Selvarajan

Garelnabi

et al. 2008

Journal of Lipid Research

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Low-dose aspirin therapy has become a standard in the treatment of cardiovascular diseases. Aspirin has been shown to inhibit atherosclerosis in mouse models. To determine the mechanisms by which aspirin might inhibit atherosclerosis, we incubated HEPG2 cells and rat primary hepatocytes with aspirin or salicylic acid and noted an increase in paraoxonase 1(PON1) activity in the medium, together with an induction of PON1 and apolipoprotein A-I (apoA-I) gene expression. Mice treated with aspirin also showed a 2-fold increase in plasma PON1 activity and a significant induction of both PON1 and apoA

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Section: Resultsmentioning

confidence: 99%

Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin

Jaichander

Selvarajan

Garelnabi

et al. 2008

Journal of Lipid Research

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“…Further studies are required to determine whether, in addition to its effects on apoC-III expression, Rev-erb␣ modulates serum triglyceride metabolism via such additional, complementary mechanisms. Since the sequence of the Ϫ33/Ϫ16 fragment of the human apoC-III promoter that binds Reverb␣ is functionally conserved in the mouse promoter (42), it is likely that Rev-erb␣ also plays a role as physiological repressor of apoC-III expression in man. The Rev-erb orphan receptor subfamily consists of two different genes, Rev-erb␣ and Rev-erb␤, that both bind similar response elements (29).…”

Section: Downloaded Frommentioning

confidence: 99%

Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription

Raspé

Duez

Mansén

et al. 2002

Journal of Lipid Research

163

118

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“…Highly conserved noncoding sequences were also observed near and between exons of most BTK region genes. Two conserved sequence elements located within the BTK transcription unit were demonstrated to function as tissue-specific silencers of BTK in T cells; sequence conservation has also been used by other authors to identify elements serving regulatory functions that are conserved in human and mouse (Januzzi et al 1992;Renucci et al 1992). In fact, because regulatory sequences are so often conserved in both position and sequence in human and mouse, comparative sequence alignments currently represent the most efficient means of identifying promoters, enhancers, silencers, and other regulatory elements.…”

Section: Human and Mouse Regions Compared At The Level Of Dna Sequencementioning

confidence: 99%

Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale

Carver¹,

Stubbs²

1997

Genome Res.

117

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Over the past decade, conservation of genetic linkage groups has been shown in mammals and used to great advantage, fueling significant exchanges of gene mapping and functional information especially between the genomes of humans and mice. As human physical maps increase in resolution from chromosome bands to nucleotide sequence, comparative alignments of mouse and human regions have revealed striking similarities and surprising differences between the genomes of these two best-mapped mammalian species. Whereas, at present, very few mouse and human regions have been compared on the physical level, existing studies provide intriguing insights to genome evolution, including the observation of recent duplications and deletions of genes that may play significant roles in defining some of the biological differences between the two species. Although high-resolution conserved marker-based maps are currently available only for human and mouse, a variety of new methods and resources are speeding the development of comparative maps of additional organisms. These advances mark the first step toward establishment of the human genome as a reference map for vertebrate species, providing evolutionary and functional annotation to human sequence and vast new resources for genetic analysis of a variety of commercially, medically, and ecologically important animal models.

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Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: Genomic, mRNA, and protein sequences with comparisons to other species

Cited by 36 publications

References 26 publications

Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin

Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin

Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription

Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale

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