Characterization of the metabolites of <i>trans</i>-resveratrol-3-<i>O</i>-glucoside in monkeys and dogs

Mei-ying, SU; Dong, Chen; Wan, Jiyun; Qu, Wendong; Mao-jin, Zhou

doi:10.1080/10286020.2021.1878157

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Then the loss of the C 2 H 2 O fragment was observed, and the ion at m/z 185.0594 (C 12 H 10 O 3 ) was produced. Combined with mass spectrometry data and references, it was identified as trans‐polydatin [31, 32]. In Figure S5B, in negative mode, Peak 4 with a [M‐H] − formula of C 21 H 20 O 10 at m/z 431.0986.…”

Section: Resultsmentioning

confidence: 99%

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Wang

Chen

Sun

et al. 2023

J of Separation Science

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Neuraminidase is an important target in the treatment of the influenza A virus.Screening natural neuraminidase inhibitors from medicinal plants is crucial for drug research. This study proposed a rapid strategy for identifying neuraminidase inhibitors from different crude extracts (Polygonum cuspidatum, Cortex Fraxini, and Herba Siegesbeckiae) using ultrafiltration combined with mass spectrometry guided by molecular docking. Firstly, the main component library of the three herbs was established, followed by molecular docking between the components and neuraminidase. Only the crude extracts with numbers of potential neuraminidase inhibitors identified by molecular docking were selected for ultrafiltration. This guided approach reduced experimental blindness and improved efficiency. The results of molecular docking indicated that the compounds in Polygonum cuspidatum demonstrated good binding affinity with neuraminidase. Subsequently, ultrafiltration-mass spectrometry was employed to screen for neuraminidase inhibitors in Polygonum cuspidatum. A total of five compounds were fished out, and they were identified as trans-polydatin, cispolydatin, emodin-1-O-β-D-glucoside, emodin-8-O-β-D-glucoside, and emodin.The enzyme inhibitory assay showed that they all had neuraminidase inhibitory effects. In addition, the key residues of the interaction between neuraminidase and fished compounds were predicted. In all, this study could provide a strategy for the rapid screening of the potential enzyme inhibitors from medicinal herbs.

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Section: Resultsmentioning

confidence: 99%

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Wang

Chen

Sun

et al. 2023

J of Separation Science

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Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far

et al. 2023

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Polydatin is an active polyphenol displaying multifaceted benefits. Recently, growing studies have noticed its potential therapeutic effects on bone and joint disorders (BJDs). Therefore, this article reviews recent in vivo and in vitro progress on the protective role of polydatin against BJDs. An insight into the underlying mechanisms is also presented. It was found that polydatin could promote osteogenesis in vitro, and symptom improvements have been disclosed with animal models of osteoporosis, osteosarcoma, osteoarthritis, and rheumatic arthritis. These beneficial effects obtained in laboratory could be mainly attributed to the bone metabolism-regulating, anti-inflammatory, antioxidative, apoptosis-regulating, and autophagy-regulating functions of polydatin. However, studies on human subjects with BJDs that can lead to early identification of the clinical efficacy and adverse effects of polydatin have not been reported yet. Accordingly, this review would serve as a starting point for pursuing clinical trials. Additionally, future emphasis should also be devoted to the low bioavailability and prompt metabolism nature of polydatin. In summary, well-designed clinical trials of polydatin in BJD patients are in demand, and its pharmacokinetic nature must be taken into account.

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Characterization of the metabolites of trans-resveratrol-3-O-glucoside in monkeys and dogs

Cited by 2 publications

References 13 publications

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking

Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far

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