Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far

Abstract

Polydatin is an active polyphenol displaying multifaceted benefits. Recently, growing studies have noticed its potential therapeutic effects on bone and joint disorders (BJDs). Therefore, this article reviews recent in vivo and in vitro progress on the protective role of polydatin against BJDs. An insight into the underlying mechanisms is also presented. It was found that polydatin could promote osteogenesis in vitro, and symptom improvements have been disclosed with animal models of osteoporosis, osteosarcoma, osteoarthritis, and rheumatic arthritis. These beneficial effects obtained in laboratory could be mainly attributed to the bone metabolism-regulating, anti-inflammatory, antioxidative, apoptosis-regulating, and autophagy-regulating functions of polydatin. However, studies on human subjects with BJDs that can lead to early identification of the clinical efficacy and adverse effects of polydatin have not been reported yet. Accordingly, this review would serve as a starting point for pursuing clinical trials. Additionally, future emphasis should also be devoted to the low bioavailability and prompt metabolism nature of polydatin. In summary, well-designed clinical trials of polydatin in BJD patients are in demand, and its pharmacokinetic nature must be taken into account.

Efficacy of traditional Chinese medicine on diabetic cardiomyopathy in animal models: a systematic review and meta-analysis

“…The forest plot analysis demonstrated that polydatin exhibited the exceptional efficacy in cardiac function, specifically in FS and E/A ( Supplementary Figure S1, S2 ). Polydatin, derived from thuja’s rhizome and roots ( Zhang et al, 2023 ), is a natural compound with a history of traditional use in treating inflammation, infection, jaundice, skin burns, and hyperlipidemia ( Luo et al, 2022 ). Polydatin stimulates antifibrotic mechanisms and Nrf2-associated signaling pathways, while inhibiting NF-κB improves glycolipid metabolism following its administration ( Karami et al, 2022 ).…”