Characterization of the major histocompatibility complex class I chain-related gene B (MICB) polymorphism in a northern Chinese Han population: The identification of a new MICB allele, MICB*023

Liu, XueXiang; Tian, Wei; Li, Lixin; Cai, JinHong

doi:10.1016/j.humimm.2011.05.013

Cited by 25 publications

(42 citation statements)

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“…Maximum likelihood haplotype frequencies were estimated using the expectation-maximization (EM) algorithm, as implemented in the program ARLEQUIN 3.5. The classic coefficients of LD, D, and of normalized LD, which is also termed the relative delta value (D rel), were computed for each individual haplotype as described previously [20,[25][26][27]. Fisher's exact test was performed to determine the significance of D. The LD analysis was restricted to HLA-B-MICB, MICA-MICB haplotypes with observed frequencies >1.5%.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the PCR-SBT method [20], the G/A dimorphism at nucleotide position 1147 in exon 6, which differentiates MICB ⁄ 005:02 from MICB ⁄ 010, was examined using a PCR-SSP method in this study.…”

Section: Discussionmentioning

confidence: 99%

“…PCR-SBT for exons 2, 3 and 4 of MICB gene was performed as recently described by us [20]. The sequencing was repeated in at least 1 independent PCR for samples showing an unexpected association with HLA-B or MICA.…”

Section: Micb Typing For Exons 2 3 Andmentioning

confidence: 99%

“…Presently, MICB polymorphism has only been characterized for a very few ethnic groups [20][21][22][23][24], information is still limited about MICB alleles and MICB-containing HLA haplotypes in Chinese Han populations residing in different geographic locations. In a recent study, we reported the MICB allelic variants in a northern Chinese Han population using polymerase chain reaction sequence-based typing (PCR-SBT) technology [20].…”

Section: Introductionmentioning

confidence: 99%

“…In a recent study, we reported the MICB allelic variants in a northern Chinese Han population using polymerase chain reaction sequence-based typing (PCR-SBT) technology [20]. In this study, we investigated the MICB allelic distribution in a Chinese Han population in Hunan province.…”

Section: Introductionmentioning

confidence: 99%

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MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

Liu

Pan

et al. 2012

Human Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Micb Typing For Exons 2 3 Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

Liu

Pan

et al. 2012

Human Immunology

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Distribution of MICB diversity in the Zhejiang Han population: PCR sequence-based typing for exons 2–6 and identification of five novel MICB alleles

Ying

Tao

et al. 2013

Immunogenetics

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The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches. In the present study, a novel polymerase chain reaction sequence-based typing (PCR-SBT) method was established for the genotyping of MICB exons 2-6, and the allelic frequency of MICB in the Zhejiang Han population was investigated. Among 400 unrelated healthy Han individuals from Zhejiang Province, China, a total of 20 MICB alleles were identified, of which MICB*005:02:01, MICB*002:01:01, and MICB*004:01:01 were the most predominant alleles, with frequencies of 0.57375, 0.1225, and 0.08375, respectively. Nine MICB alleles were detected on only one occasion, giving a frequency of 0.00125. Of the 118 distinct MICB ∼ HLA-B haplotypes identified, 42 showed significant linkage disequilibrium (P < 0.05). Haplotypes MICB*005:02:01 ∼ B*46:01, MICB*005:02:01 ∼ B*40:01, and MICB*008 ∼ B*58:01 were the most common haplotypes, with frequencies of 0.0978, 0.0761, and 0.0616, respectively. Five novel alleles, MICB*005:07, MICB*005:08, MICB*027, MICB*028, and MICB*029 were identified. Compared with the MICB*005:02:01 sequence, a G > A substitution was observed at nucleotide position 210 in MICB*005:07, and a 1,134 T > C substitution in MICB*005:08 and an 862 G > A substitution in MICB*027 were detected. In addition, it appears that MICB*028 probably arose from MICB*004:01:01 with an A to G substitution at position 1,147 in exon 6. MICB*029 had a G > T transversion at nucleotide position 730 in exon 4, compared with that of MICB*002:01:01. On the basis of the new PCR-SBT assay, these observed results demonstrated MICB allelic variations in the Zhejiang Han population.

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Nomenclature for factors of the HLA system, update September 2011

Marsh¹

2012

Human Immunology

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Characterization of the major histocompatibility complex class I chain-related gene B (MICB) polymorphism in a northern Chinese Han population: The identification of a new MICB allele, MICB*023

Cited by 25 publications

References 43 publications

MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

Distribution of MICB diversity in the Zhejiang Han population: PCR sequence-based typing for exons 2–6 and identification of five novel MICB alleles

Nomenclature for factors of the HLA system, update September 2011

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