Nomenclature for factors of the HLA system, update September 2011

Marsh, Steven G.E.

doi:10.1016/j.humimm.2011.10.010

Cited by 1 publication

(1 citation statement)

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“…None of the existing theories have as yet satisfactorily explained the underlying mechanism and the differential association of HLAB27 subtypes with AS. There are 86 HLA-B27 alleles based on nucleotide sequence differences, but at the translated protein level, the number of subtypes includes 81 different isoforms [7]. The common sub-types B*27:02, B*27:04 and B*27:05 are strongly associated with AS.…”

Section: Introductionmentioning

confidence: 99%

Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia

Vojvodic

Ademović-Sazdanić²,

Busarcevic³

2012

Balkan Journal of Medical Genetics

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There are numerous studies showing the role of human leukocyte antigens (HLAs) related with susceptibility or resistance to certain diseases. The aim of this study was to determine the association of HLA-B27 with ankylosing spondylitis (AS), polyarthralgia, lumboishialgia, acute anterior uveitis (AAU), psoriatic arthritis (PA), synovitis coxae and rheumatoid arthritis (RA) in patients from Vojvodina, Serbia. An HLA I class typing was performed by the serological immunomagnetic two-color fluorescence method using peripheral blood T lymphocytes in 97 patients and 224 healthy controls from the population of Vojvodina, Serbia. We calculated HLA-B27 frequencies, relative risk (RR), ethiologic fraction (EF), e.g., population attributive risk, when RR was greater than 1, while, preventive fraction (PF) was calculated when RR was lower than 1. This study revealed the strongest association of AS with HLAB27 antigen: RR = 25.0, while the EF was greater than 0.15, respectively. The χ2 test showed the significant difference (p <0.05) in HLA-B27 in patients with AS in comparison to controls (χ2 = 52.5). It was concluded that there is a positive association of HLA-B27 with AS and that HLA-B27 can serve as a marker for predisposition to diseases.

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Section: Introductionmentioning

confidence: 99%