Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

Gene structure and transcription of IRF-1 and IRF-7 in the mandarin fish Siniperca chuatsi

“…The gene structure of mandarin fish IRF-7 was different from the only known vertebrate IRF-7, i.e. human IRF-7 gene structure, which has 9 exons and 8 introns (Zhang and Pagano, 1997;Au et al, 1998). The mandarin fish IRF-7 contains a serine-rich domain located in the C-terminal region, just as its homologue in mammals (Au et al, 1998).…”

“…human IRF-7 gene structure, which has 9 exons and 8 introns (Zhang and Pagano, 1997;Au et al, 1998). The mandarin fish IRF-7 contains a serine-rich domain located in the C-terminal region, just as its homologue in mammals (Au et al, 1998). Available literature shows that IRF-7 may be regulated at two distinct levels: induced transcription after IFN and LPS stimulation and C-terminal phosphorylation following viral infection.…”

Toll-like receptor signal transduction

“…Studies of IFN regulation also suggest that the autocrine/paracrine action of INF-β produced by IRF3 can induce IRF7 de novo which activates IFN-α (Au et al, 1998;Marie et al, 1998). Regulation of IFN production via TLRs is entirely distinct in pDCs.…”

HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators

“…Since dominant negative forms of IRF-3 and IRF-7 have been shown to interfere with IFN, RANTES and IP-10 RNA production (Au et al, 1998;Genin et al, 2000;Lin et al, 1998Lin et al, , 1999aMarie et al, 1998;Sato et al, 1998;Yoneyama et al, 1998), we next determined whether vIRF-1 repressed IRF-3-or IRF-7-mediated transcriptional activity. A transient expression assay was performed using the RANTES promoter construct together with IRF-3, IRF-7 and/or vIRF-1 expression plasmids.…”

“…Recent studies have demonstrated that IRF-3 and IRF-7 play an important role in the virus-induced type I interferon gene activation following virus infection (Au et al, 1998;Lin et al, 1998Lin et al, , 1999aMamane et al, 1999;Marie et al, 1998;Sato et al, 1998;Wathelet et al, 1998;Weaver et al, 1998;Yoneyama et al, 1998). Virus-induced C-terminal phosphorlyation of IRF-3 promotes cytoplasmic to nuclear translocation, DNA binding, association with CBP/p300 histone acetyltransferases and transactivation of downstream target genes.…”