Characterization of the Clear-PEM breast imaging scanner performance

Albuquerque, E.; Almeida, F. G.; Almeida, Pedro; Auffray, E.; Barbosa, Jorge G.; Bastos, A. L.; Bexiga, V.; Bugalho, R.; Cardoso, Carlota; Carmona, Susana; Carneiro, João; Carriço, B.; Ferreira, Carla; Ferreira, Nuno C.; Ferreira, Miguel; Frade, M.; Gonçalves, Fernando M.; Guerreiro, C.; Lecoq, P.; Leong, C.; Lousa, P.; Machado, Pedro A. N.; Martins, M. V.; Matela, Nuno; Moura, R.; Neves, Joana; Neves, P.N.B.; Oliveira, N.; Ortigao, Catarina; Piedade, Fernando; Pinheiro, J. F.; Relvas, Paulo; Rivetti, A.; Rodrigues, Pedro; Rolo, I; Santos, Ana Isabel; Santos, J. Vara; Silva, Manuel M.; Tavernier, S.; Teixeira, I.C.; Teixeira, J.P.; Silva, J. C.; Silva, R.; Trindade, A.; Varela, J.

doi:10.1109/nssmic.2009.5401796

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…The timing resolution for other PMT-based breast dedicated PET imaging systems is under 10 ns FWHM: 1.2 ns [10], 5.2 ns [11], and 8.1 ns [12]. In order to achieve sub 10 ns timing resolution with PSAPDs, additional calibration parameters were used and a calibration method was created in order to compensate for the nonoptimal timing of the RENA-3 ASIC.…”

Section: Introductionmentioning

confidence: 99%

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Reynolds

Olcott

Pratx

et al. 2011

IEEE Trans. Med. Imaging

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We are developing a dual panel breast-dedicated positron emission tomography (PET) system using LSO scintillators coupled to position sensitive avalanche photodiodes (PSAPD). The charge output is amplified and read using NOVA RENA-3 ASICs. This paper shows that the coincidence timing resolution of the RENA-3 ASIC can be improved using certain list-mode calibrations. We treat the calibration problem as a convex optimization problem and use the RENA-3’s analog-based timing system to correct the measured data for time dispersion effects from correlated noise, PSAPD signal delays and varying signal amplitudes. The direct solution to the optimization problem involves a matrix inversion that grows order (n3) with the number of parameters. An iterative method using single-coordinate descent to approximate the inversion grows order (n). The inversion does not need to run to convergence, since any gains at high iteration number will be low compared to noise amplification. The system calibration method is demonstrated with measured pulser data as well as with two LSO-PSAPD detectors in electronic coincidence. After applying the algorithm, the 511 keV photopeak paired coincidence time resolution from the LSO-PSAPD detectors under study improved by 57%, from the raw value of 16.3 ± 0.07 ns full-width at half-maximum (FWHM) to 6.92 ± 0.02 ns FWHM (11.52 ± 0.05 ns to 4.89 ± 0.02 ns for unpaired photons).

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Section: Introductionmentioning

confidence: 99%

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Reynolds

Olcott

Pratx

et al. 2011

IEEE Trans. Med. Imaging

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“…On the other side, dedicated breast PET scanners provide fully tomographic information, either by encircling the breast with PET detectors (Furuta et al 2010, Moliner et al 2012, Ravindranath et al 2012) or by rotating two or more heads around the breast (Wu et al 2009, Raylman et al 2011, Albuquerque et al 2009). These scanners are sometimes referred to as breast PET (bPET).…”

Section: Introductionmentioning

confidence: 99%

Preliminary performance characterization of DbPET2.1, a PET scanner dedicated to the imaging of the breast and extremities

Ferrero

Peng

Burkett

et al. 2015

Biomed. Phys. Eng. Express

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The combined effort of several laboratories at our institution resulted in the building of the first high resolution PET/CT prototype dedicated to imaging the body extremities. Ongoing clinical trials for breast cancer diagnosis and assessment of response to treatment underlined the need for a second generation prototype with improved electronics and spatial resolution. A preliminary version has been assembled and fully characterized. In this work we present further improvements in the detector performance as well as the readout electronics for the PET component. The detector consists of a 16×16 array of 1.27×1.27×20mm3 LYSO crystals, the smallest crystal size for completed breast PET prototypes to date, directly coupled to a position-sensitive photomultiplier tube (PSPMT). The scintillator crystals are polished on all 6 faces and separated by ~70 μm ESR reflector. The readout electronics were redesigned to reduce their footprint and improve timing resolution. We report a detector energy and timing resolution of 12% and 1.0 ns, respectively, and an average intrinsic spatial resolution of 1.29 mm (central row in one detector array). The new PET/CT has been fully assembled and initial system characterization is being perfomed. We report a system energy resolution of 15.7%, a timing resolution of 1.5 ns and an FBP image spatial resolution in the center of the FOV of 1.6 mm.

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Performance comparison of a dedicated total breast PET system with a clinical whole-body PET system: a simulation study

Samanta¹,

Jiang²,

Hamdi³

et al. 2021

Phys. Med. Biol.

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This paper presents a novel PET geometry for breast cancer imaging. The scanner consists of a ‘stadium’ (a rectangle with two semi-circles on opposite sides) shaped ring, along with anterior and posterior panels to provide high sensitivity and high spatial resolution for an imaging field-of-view (FOV) that include both breasts, mediastinum and axilla. We simulated this total-breast PET system using GATE and reconstructed the coincidence events using a GPU-based list-mode image reconstruction implementing maximum likelihood expectation-maximization (ML-EM) algorithm. The rear-panel is made up of a single layer of LSO crystals (3.2 × 3.2 × 20 mm3 each), while the ‘stadium’-shaped elongated ring and the anterior panel are made with dual-layered LSO crystals (1.6 × 1.6 × 6 mm3 each). The energy resolution and coincidence resolving time of all detectors are assumed to be 12% and 250 ps full-width-at-half-maximum, respectively. Various sized simulated lesions (4, 5, 6 mm) having 4:1, 5:1, and 6:1 lesion-to-background radioactivity concentration ratios, mimicking different biological uptakes, were strategically located throughout a volumetric torso phantom. We compared system sensitivity and lesion detectability of the dedicated total-breast PET system to a state-of-the-art clinical whole-body PET scanner. The mean sensitivity of the total-breast PET system is 3.21 times greater than that of a whole-body PET scanner in the breast regions. The total-breast PET system also provides better contrast-recovery coefficients for lesions of all sizes and lesion-to-background ratios in the breast when compared to a reference clinical whole-body PET scanner. Receiver operating characteristics (ROC) study shows the area under the ROC curve is 0.948 and 0.924 for the total-breast system and the whole-body PET scanner, respectively, in the detection of 4 mm diameter lesions with 4:1 lesion-to-background ratio. This study demonstrates our novel geometry can provide an imaging FOV larger than conventional PEM systems to simultaneously image both breasts, chest wall and axillae with significantly improved lesion detectability in the breasts when compared to a whole-body PET scanner.

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Characterization of the Clear-PEM breast imaging scanner performance

Cited by 6 publications

References 4 publications

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Convex Optimization of Coincidence Time Resolution for a High-Resolution PET System

Preliminary performance characterization of DbPET2.1, a PET scanner dedicated to the imaging of the breast and extremities

Performance comparison of a dedicated total breast PET system with a clinical whole-body PET system: a simulation study

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