Preliminary performance characterization of DbPET2.1, a PET scanner dedicated to the imaging of the breast and extremities

Abstract

The combined effort of several laboratories at our institution resulted in the building of the first high resolution PET/CT prototype dedicated to imaging the body extremities. Ongoing clinical trials for breast cancer diagnosis and assessment of response to treatment underlined the need for a second generation prototype with improved electronics and spatial resolution. A preliminary version has been assembled and fully characterized. In this work we present further improvements in the detector performance as well as the readout electronics for the PET component. The detector consists of a 16×16 array of 1.27×1.27×20mm3 LYSO crystals, the smallest crystal size for completed breast PET prototypes to date, directly coupled to a position-sensitive photomultiplier tube (PSPMT). The scintillator crystals are polished on all 6 faces and separated by ~70 μm ESR reflector. The readout electronics were redesigned to reduce their footprint and improve timing resolution. We report a detector energy and timing resolution of 12% and 1.0 ns, respectively, and an average intrinsic spatial resolution of 1.29 mm (central row in one detector array). The new PET/CT has been fully assembled and initial system characterization is being perfomed. We report a system energy resolution of 15.7%, a timing resolution of 1.5 ns and an FBP image spatial resolution in the center of the FOV of 1.6 mm.

High-resolution18F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

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Investigating human exposure to a practical wireless power transfer system using and the effect about key parameters of dosimetry

“…https://doi.org/10.1371/journal.pone.0236929.g010 In this paper, the skin conductivity proposed by Gabriel's model is used as it is. However, recently, a skin conductivity model has been proposed by De Santis et al [40].…”

Implementation and CT sampling characterization of a third-generation SPECT–CT system for dedicated breast imaging

“…Various groups have developed stand-alone, human breast computed tomography (BCT) systems [32][33][34] (beyond labbased systems that can only image phantoms or specimens 35,36 ), as well as dual-modality systems 26,37 for dedicated breast imaging, only capable of traversing simple circular orbits; for one system, the PET subsystem is capable of helical acquisitions. 38 Software-based suppression of cone beam artifacts has been investigated, but the underlying acquired data remain incompletely sampled, therefore necessitating more accurate data acquisition. To overcome cone beam sampling artifacts in CT and provide better sampling close to the chest wall, our group previously developed independent CT and single-photon emission computed tomography (SPECT) subsystems capable of fully 3-D motions, allowing complex acquisition trajectories [39][40][41] (so-called generation 1).…”