Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an<i>in vitro</i>and<i>in vivo</i>study

Souza, Verónica; Franco, Élida Paula Dini de; Araújo, Maria Elisa Melo Branco de; Messias, Márcia Cristina Fernandes; Priviero, Fernanda; Sawaya, Alexandra Christine Helena Frankland; Carvalho, Patrícia de Oliveira

doi:10.1002/jmr.2509

Cited by 45 publications

(38 citation statements)

References 39 publications

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“…This study provides a rational basis for the traditional use of gnaphalium affine against gout. The study on in vitro XO-inhibitory activity of the aglycone hesperetin and its glycosylated forms (hesperidin and G-hesperidin) and their effects on the plasma lipid profile and the oxidative–antioxidative system has been carried out in rats ( 80 ) . The concentrations of the major conjugated metabolites in rat plasma after oral administration of these compounds were also determined.…”

Section: Current Research and Trends On Flavonoidsmentioning

confidence: 99%

Flavonoids: an overview

Panche¹,

2016

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Flavonoids, a group of natural substances with variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These natural products are well known for their beneficial effects on health and efforts are being made to isolate the ingredients so called flavonoids. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Research on flavonoids received an added impulse with the discovery of the low cardiovascular mortality rate and also prevention of CHD. Information on the working mechanisms of flavonoids is still not understood properly. However, it has widely been known for centuries that derivatives of plant origin possess a broad spectrum of biological activity. Current trends of research and development activities on flavonoids relate to isolation, identification, characterisation and functions of flavonoids and finally their applications on health benefits. Molecular docking and knowledge of bioinformatics are also being used to predict potential applications and manufacturing by industry. In the present review, attempts have been made to discuss the current trends of research and development on flavonoids, working mechanisms of flavonoids, flavonoid functions and applications, prediction of flavonoids as potential drugs in preventing chronic diseases and future research directions.

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Section: Current Research and Trends On Flavonoidsmentioning

confidence: 99%

Flavonoids: an overview

Panche¹,

2016

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“…Additionally, diosmetin and chrysoeriol show good activity, but they are generally less efficient than luteolin for the presence of a methoxy group at C4' or C3', respectively, which decreases the antioxidant potential [74]. Moreover, in general, O-glycosylated derivatives show much lower antioxidant activity than the corresponding aglycones, owing to the fact that a good part of the radical quenching mechanism of flavones relies on the presence of free OH groups [75].…”

Section: Antioxidant and Anti-inflammatory Activity Of Citrus Flavonesmentioning

confidence: 99%

Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties

Barreca

Mandalari

Calderaro

et al. 2020

Plants

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Citrus spp. are among the most widespread plants cultivated worldwide and every year millions of tons of fruit, juices, or processed compounds are produced and consumed, representing one of the main sources of nutrients in human diet. Among these, the flavonoids play a key role in providing a wide range of health beneficial effects. Apigenin, diosmetin, luteolin, acacetin, chrysoeriol, and their respective glycosides, that occur in concentrations up to 60 mg/L, are the most common flavones found in Citrus fruits and juices. The unique characteristics of their basic skeleton and the nature and position of the substituents have attracted and stimulated vigorous investigations as a consequence of an enormous biological potential, that manifests itself as (among other properties) antioxidant, anti-inflammatory, antiviral, antimicrobial, and anticancer activities. This review analyzes the biochemical, pharmacological, and biological properties of Citrus flavones, emphasizing their occurrence in Citrus spp. fruits and juices, on their bioavailability, and their ability to modulate signal cascades and key metabolic enzymes both in vitro and in vivo. Electronic databases including PubMed, Scopus, Web of Science, and SciFinder were used to investigate recent published articles on Citrus spp. in terms of components and bioactivity potentials.

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“…Recently, De Souza et al . compared the antioxidant activity of hesperidin, hesperetin and G‐hesperidin in vitro and in vivo, administrating each of these for 30 days at 1 mmol/kg body mass to Wistar male rats and demonstrating that the aglycone form is a stronger in vitro xanthine oxidase inhibitor, increasing SOD activity in the liver of the animals. Previously in 2012, Yang et al .…”

Section: Biological Properties Of Citrus Flavanonesmentioning

confidence: 99%

Flavanones: Citrus phytochemical with health‐promoting properties

et al. 2017

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Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from ∼180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer. Moreover, among other properties, they also show anti-inflammatory, antiviral, and antimicrobial activities. This review analyzes the biochemistry, pharmacology, and biology of Citrus flavanones, emphasizing the occurrence in Citrus fruits and juices and their bioavailability, structure-function correlations and ability to modulate signal cascades both in vitro and in vivo. © 2017 BioFactors, 43(4):495-506, 2017.

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Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: anin vitroandin vivostudy

Cited by 45 publications

References 39 publications

Flavonoids: an overview

Flavonoids: an overview

Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties

Flavanones: Citrus phytochemical with health‐promoting properties

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