Characterization of the anisotropic mechanical behavior of human abdominal wall connective tissues

Astruc, Laure; Meulaere, Maurice De; Witz, Jean‐François; Nováček, Vít; Turquier, F.; Hoc, Thierry; Brieu, Mathias

doi:10.1016/j.jmbbm.2018.03.012

Cited by 32 publications

(23 citation statements)

References 26 publications

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“…Over the years, our research team characterized various soft tissues, from animal or human origin: rat abdominal wall [49], abdominal aponeuroses [50] and sheathing tissues [11], ewe [17] and human pelvic tissues [6,[51][52][53]. Mechanical characterization occurred under uniaxial tension to optimize the use of collected sample and build statistically significant databases.…”

Section: Mechanical Frameworkmentioning

confidence: 99%

“…Mechanical characterization occurred under uniaxial tension to optimize the use of collected sample and build statistically significant databases. This isotropic law was applied to isotropic and anisotropic tissues as well [11,50]. For an anisotropic material, the identification of all the mechanical properties would require, in uniaxial tension, a large number of tests in different loading directions to reach a complete characterization of the material mechanical parameters.…”

Section: Mechanical Frameworkmentioning

confidence: 99%

“…To identify the mechanical behavior of soft tissues, the literature reveals numerous characterization protocols. Biological soft tissues are tested under uniaxial or biaxial traction [4][5][6][7][8][9][10][11], inflation test [12][13][14], ball-burst test [15] etc. Sample size is often a major limitation in the study of biological tissues.…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, when described, the most common method is a thresholding method using a pre-stress or a pre-force [11,21,22,36,47,48]. This thresholding can be performed during the test or in postprocessing.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is there any objective and independent characterization and modeling of soft biological tissues?

Morch

Astruc

Mayeur

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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The characterization of soft tissue raises several difficulties. Indeed, soft biological tissues usually shrink when dissected from their in vivo location. This shrinkage is characteristic of the release of residual stresses, since soft tissues are indeed often pre-stressed in their physiological configuration.During experimental loading, large extension at very low level of force are expected and assumed to be related to the progressive recruitment and stretching of fibers. However, the first phase of the mechanical test is also aiming at recovering the pre-stressed in vivo behavior. As a consequence, the initial phase, corresponding to the recovering of prestress and/or recruitment of fiberes, is questionable and frequently removed. One of the preferred methods to erase it consists in applying a preforce or prestress to the sample: this allows to easily get rid of the sample retensioning range. However this operation can impact the interpretation of the identified mechanical parameters.This study presents an evaluation of the impact of the data processing on the mechanical properties of a numerically defined material. For this purpose, a finite element simulation was performed to replicate a uniaxial tensile test on a biological soft tissue sample. The influence of different pre-stretches on the mechanical parameters of a second order Yeoh model was investigated.The Yeoh mechanical parameters, or any other strain energy density, depend strongly on any pre-and post-processing choices: they adapt to compensate the error made when choosing an arbitrary level of prestretch or prestress. This observation spreads to any modeling approach used in soft tissues. Mechanical parameters are indeed naturally bound to the choice of the pre-stretch (or pre-stress) through the elongation and the constitutive law. Regardless of the model, it would therefore be pointless to compare mechanical parameters if the conditions for the processing of experimental raw data are not fully documented.

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Section: Mechanical Frameworkmentioning

confidence: 99%

Section: Mechanical Frameworkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is there any objective and independent characterization and modeling of soft biological tissues?

Morch

Astruc

Mayeur

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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“…Similar stiffness investigations were then conducted to compare and evaluate surgical meshes (Eliason et al, 2011;Kirilova et al, 2012;Tomaszewska, 2016). Some papers address identification of the mechanical properties of specific components in the abdominal wall based on ex vivo tests, e.g., connective tissues in the abdominal wall (Astruc et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

In vivo performance of intraperitoneal onlay mesh after ventral hernia repair

Lubowiecka

Tomaszewska

Szepietowska

et al. 2020

Clinical Biomechanics

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Background: Ventral hernia repair needs to be improved since recurrence, postoperative pain and other complications are still reported in many patients. The behavior of implants in vivo is not sufficiently understood to design a surgical mesh mechanically compatible with the human abdominal wall. Methods: This analysis was based on radiological pictures of patients who underwent laparoscopic ventral hernia repair. The pictures show the trunk of the patient at rest in a standing position and under side bending. The change in the distance between different tacks due to trunk movement was analyzed, which allowed us to determine the in vivo elongation of the mesh incorporated into the abdominal wall. Findings: The relative elongations of the surgical mesh varied from a few percent to greater than 100% in two cases. The median of the median relative elongations obtained for all patients is 9.5%, and the median of the maximum relative elongations for all patients is 32.6%. The maximum elongation occurs between tacks that are next to each other. Trunk movement causes implant deformation, and this study provides quantitative information regarding changes in the distance between fasteners. Interpretation: The physiological movement of the human abdomen must be regarded as a very important factor in mesh deformation and should be considered in surgical practice to reduce the hernia recurrence rate and postoperative pain.

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Cobweb‐Inspired Micro/Nanostructured Scaffolds for Soft Tissue Regeneration with Inhibition Effect of Fibrosis under Dynamic Environment

Jiao,

Li,

Liu

et al. 2023

Adv Healthcare Materials

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In soft tissue repair, fibrosis can lead to repair failure and long‐term chronic pain in patients. Excessive mechanical stimulation of fibroblasts is one of the causes of fibrosis during abdominal wall regeneration. Inspired by the cobweb, a polycaprolactone beaded fiber is prepared by electrospinning. The cobweb‐inspired structure attenuates the mechanical stimulation of cells under a dynamic environment. Nano‐protrusions are introduced into the scaffold for further inhibition of fibrosis by self‐induced crystallization. A machine is built for in vitro dynamic culture and rat abdominal subcutaneous embedding experiments are performed to verify the inhibiting effect of fibrosis in a dynamic environment in vivo. Results show that the expression of integrin β1 and α‐smooth muscle actin is inhibited by the cobweb‐inspired structure under dynamic culture. The results of hematoxylin and eosin and Masson's trichrome indicate that the cobweb‐inspired structure has a good inhibitory effect on fibrosis in a dynamic environment in vivo. In general, the cobweb‐inspired scaffold with nano‐protrusions has a good ability to inhibit fibrosis under both static and dynamic environments. It is believed that the scaffold has promising applications in the field of inhibiting fibrosis caused by mechanical stimulation.

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Characterization of the anisotropic mechanical behavior of human abdominal wall connective tissues

Cited by 32 publications

References 26 publications

Is there any objective and independent characterization and modeling of soft biological tissues?

Is there any objective and independent characterization and modeling of soft biological tissues?

In vivo performance of intraperitoneal onlay mesh after ventral hernia repair

Cobweb‐Inspired Micro/Nanostructured Scaffolds for Soft Tissue Regeneration with Inhibition Effect of Fibrosis under Dynamic Environment

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