Characterization of the angular memory effect of scattered light in biological tissues

Schott, Sam; Bertolotti, Jacopo; Léger, Jean-François; Bourdieu, Laurent; Gigan, Sylvain

doi:10.1364/oe.23.013505

Cited by 165 publications

(134 citation statements)

References 38 publications

(54 reference statements)

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“…For example, recent work establishes that light within biological tissue exhibits much stronger tilt/tilt correlations than in low-g media 32 . This is because light spreads less across both angle and space in anisotropically scattering media, making both P k and P x highly non-uniform.…”

Section: Discussionmentioning

confidence: 99%

Translation correlations in anisotropically scattering media

et al. 2015

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Controlling light propagation across scattering media by wavefront shaping holds great promise for a wide range of communications and imaging applications. However, finding the right wavefront to shape is a challenge when the mapping between input and output scattered wavefronts (i.e. the transmission matrix) is not known. Correlations in transmission matrices, especially the so-called memory-effect, have been exploited to address this limitation. However, the traditional memory-effect applies to thin scattering layers at a distance from the target, which precludes its use within thick scattering media, such as fog and biological tissue. Here, we theoretically predict and experimentally verify new transmission matrix correlations within thick anisotropically scattering media, with important implications for biomedical imaging and adaptive optics.

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Section: Discussionmentioning

confidence: 99%

Translation correlations in anisotropically scattering media

et al. 2015

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“…However, in real animal systems, the goal is to focus inside the turbid media rather than through it, and we do not have any degree of freedom to control the distance between the scatterer and the target plane. In this case, recent studies have demonstrated that the translational 53 and angular memory effects 55 will both be in play, which has not yet been fully explored. Further utilizations of optical properties can also enable to address existing challenges in in vivo imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Moderate scan range has also been demonstrated, even over a thickness of a few millimeters of tissue specimens that corresponds to several l * s in a recent report. 55 Alternatively, far-field laser speckle interferometry with two-point intensity correlation measurement was also used to image object though a turbid medium. 56,57 Working toward in vivo applications, however, one should consider the short decorrelation time of live tissues.…”

Section: Imaging Through Biological Tissuesmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

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Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with specialties in physics and engineering, we anticipate that these technologies can be translated to biological laboratories and clinical settings, which will revolutionize how we diagnose and treat a disease. To provide insight into the physical principle that enables the control of multiple light scattering in biological tissues and how recently developed techniques can improve bioimaging through thick tissues, we summarize recent progress on wavefront shaping techniques for controlling multiple light scattering in biological tissues.

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“…Since the ME FOV is inversely proportional to L, our technique works best with thin scattering media, or through more anisotropically scattering media, since anisotropy enhances the angular memory effect range [20]. Strongly anisotropic media, such as biological tissue, also exhibit the translational memory effect, which may be exploited to further the fidelity of imaging through scattering layers [26].…”

Section: Discussionmentioning

confidence: 99%

“…where k = 2π λ , L is the thickness of the scattering medium, and Θ ≈ ∆x u [18][19][20]. When C(∆x) > 0.5, the object is considered to have traveled within the ME field of view.…”

Section: Effect Of Travel Distancementioning

confidence: 99%

Imaging moving targets through scattering media

Cua¹,

Zhou²,

Yang³

2017

Opt. Express

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Optical microscopy in complex, inhomogeneous media is challenging due to the presence of multiply scattered light that limits the depths at which diffraction-limited resolution can be achieved. One way to circumvent the degradation in resolution is to use speckle-correlationbased imaging (SCI) techniques, which permit imaging of objects inside scattering media at diffraction-limited resolution. However, SCI methods are currently limited to imaging sparsely tagged objects in a dark-field scenario. In this work, we demonstrate the ability to image hidden, moving objects in a bright-field scenario. By using a deterministic phase modulator to generate a spatially incoherent light source, the background contribution can be kept constant between acquisitions and subtracted out. In this way, the signal arising from the object can be isolated, and the object can be reconstructed with high fidelity. With the ability to effectively isolate the object signal, our work is not limited to imaging bright objects in the dark-field case, but also works in bright-field scenarios, with non-emitting objects. 16. C. Ma, X. Xu, Y. Liu, and L. V. Wang, "Time-reversed adapted-perturbation (trap) optical focusing onto dynamic objects inside scattering media," Nat. Photon. 8, 931-936 (2014).

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Characterization of the angular memory effect of scattered light in biological tissues

Cited by 165 publications

References 38 publications

Translation correlations in anisotropically scattering media

Translation correlations in anisotropically scattering media

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Imaging moving targets through scattering media

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