Translation correlations in anisotropically scattering media

Judkewitz, Benjamin; Horstmeyer, Roarke; Vellekoop, Ivo M.; Papadopoulos, Ioannis; Yang, Changhuei

doi:10.1038/nphys3373

Cited by 199 publications

(191 citation statements)

References 37 publications

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“…However, in real animal systems, the goal is to focus inside the turbid media rather than through it, and we do not have any degree of freedom to control the distance between the scatterer and the target plane. In this case, recent studies have demonstrated that the translational 53 and angular memory effects 55 will both be in play, which has not yet been fully explored. Further utilizations of optical properties can also enable to address existing challenges in in vivo imaging.…”

Section: Discussionmentioning

confidence: 99%

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Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

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Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with specialties in physics and engineering, we anticipate that these technologies can be translated to biological laboratories and clinical settings, which will revolutionize how we diagnose and treat a disease. To provide insight into the physical principle that enables the control of multiple light scattering in biological tissues and how recently developed techniques can improve bioimaging through thick tissues, we summarize recent progress on wavefront shaping techniques for controlling multiple light scattering in biological tissues.

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Section: Discussionmentioning

confidence: 99%

“…This range is a function inversely related to the degree of scattering and the thickness of the turbid media L, 45,53 or proportional to λ l * s /L as recently verified. 54 According to these prior studies, biological tissues are turbid media and are good for the memory effect due to their relatively high l * s .…”

Section: Imaging Through Biological Tissuesmentioning

confidence: 99%

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Park

Lee

et al. 2018

APL Photonics

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“…The existence of both single peaked localized states and multiply peaked necklace states has been observed in layered media 46 , single mode waveguides 47 , natural materials 48 , and can be created in multimode optical fiber with mode coupling 49 . It is also of great interest to explore the disposition of energy within thin anisotropic scattering media, of importance in biomedical research 50 .…”

Section: Discussionmentioning

confidence: 99%

Diffusion in Translucent Media

Genack

Shi

2018

Conference on Lasers and Electro-Optics

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Diffusion is the result of repeated random scattering. It governs a wide range of phenomena from Brownian motion, to heat flow through window panes, neutron flux in fuel rods, dispersion of light in human tissue, and electronic conduction. It is universally acknowledged that the diffusion approach to describing wave transport fails in translucent samples thinner than the distance between scattering events such as are encountered in meteorology, astronomy, biomedicine, and communications. Here we show in optical measurements and numerical simulations that the scaling of transmission and the intensity profiles of transmission eigenchannels have the same form in translucent as in opaque media. Paradoxically, the similarities in transport across translucent and opaque samples explain the puzzling observations of suppressed optical and ultrasonic delay times relative to predictions of diffusion theory well into the diffusive regime.

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“…Strongly anisotropic media, such as biological tissue, also exhibit the translational memory effect, which may be exploited to further the fidelity of imaging through scattering layers [26].…”

Section: Discussionmentioning

confidence: 99%

Imaging moving targets through scattering media

Cua¹,

Zhou²,

Yang³

2017

Opt. Express

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Optical microscopy in complex, inhomogeneous media is challenging due to the presence of multiply scattered light that limits the depths at which diffraction-limited resolution can be achieved. One way to circumvent the degradation in resolution is to use speckle-correlationbased imaging (SCI) techniques, which permit imaging of objects inside scattering media at diffraction-limited resolution. However, SCI methods are currently limited to imaging sparsely tagged objects in a dark-field scenario. In this work, we demonstrate the ability to image hidden, moving objects in a bright-field scenario. By using a deterministic phase modulator to generate a spatially incoherent light source, the background contribution can be kept constant between acquisitions and subtracted out. In this way, the signal arising from the object can be isolated, and the object can be reconstructed with high fidelity. With the ability to effectively isolate the object signal, our work is not limited to imaging bright objects in the dark-field case, but also works in bright-field scenarios, with non-emitting objects. 16. C. Ma, X. Xu, Y. Liu, and L. V. Wang, "Time-reversed adapted-perturbation (trap) optical focusing onto dynamic objects inside scattering media," Nat. Photon. 8, 931-936 (2014).

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Translation correlations in anisotropically scattering media

Cited by 199 publications

References 37 publications

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

Diffusion in Translucent Media

Imaging moving targets through scattering media

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