Characterization of the anemia associated with chronic renal insufficiency

Loge, J.Philip; Lange, Robert D.; Moore, Carl V.

doi:10.1016/0002-9343(58)90357-7

Cited by 177 publications

(80 citation statements)

References 19 publications

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“…The diagnosed CRF patients were taken from the out patient department of Nephrology, BSMMU, who fulfill the inclusion criteria-CRF patients with anemia having hemoglobin concentration < 12gm / dl and Ccr30-50ml/min, Ccr16-29ml/ min, Ccr5-15ml/min respectively used to classify CRF patients with anemia into mild, moderate, severe CRF patients 6,8 Apparently healthy subjects were selected from the kidney donors attending out patient department of nephrology, BSMMU. CRF patients with history of kidney transplantation, liver disease, nonrenal origin of anemia (previous history of GIT bleeding, malignancy, chronic TB), history of erythropoietin therapyand history of blood transfusion during last three months [10][11][12] were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Changes in Hematological Indices in Different Stages of Chronic Renal Failure

Khanam

Begum

et al. 1970

J Bangladesh Soc Physiol

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The study was carried out to observe some aspects of hematological changes like Hb concentration, PCV and TC of RBC in different stages of Chronic Renal Failure(CRF) patients suffering from anemia. For this purpose, 65 male CRF patients with anemia and 25 apparently health male (control) subjects of age ranged from 30-50 years were selected randomly from BSMMU out patient department. Hematological parameters and renal creatinine clearance were estimated by usual laboratory technique. Data were analyzed statistically by ANOVA and Pearson's correlation coefficient test. Among the CRF patients 15 were mild, 25 were moderate and 25 were severe CRF patients with anemia. In this study, the mean Hb concentration, PCV and total count of red blood cells were significantly lower in three stages of CRF patients with anemia compared to those of healthy subjects. Again, all of these hematological values were significantly (P< 0.001) lower in moderate and severe CRF patients compared to mild cases and also in severe cases than those of moderate CRF cases with anemia. All the Hematological parameters showed positive correlation with creatinine clearance in all three stages of CRF and it was statistically significant in moderate and severe group. From the present study it may be concluded that CRF patients with anemia had lower hematological indices and the degree of changes depend on severity of renal failure. Key Words: Hemoglobin; Packed Cell Volume; Renal Failure DOI:10.3329/jbsp.v2i0.983 J Bangladesh Soc Physiol. 2007 Dec;(2): 38-41.

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Section: Methodsmentioning

confidence: 99%

Changes in Hematological Indices in Different Stages of Chronic Renal Failure

Khanam

Begum

et al. 1970

J Bangladesh Soc Physiol

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“…Decreased production (3,5,6) and shortened survival of erythrocytes (7)(8)(9)(10)(11) have been implicated as the cause of this abnormality. Re-duced availability of erythroprotein (Ep)l (12)(13)(14)(15)(16) and the presence of inhibitors to various stages of erythropoiesis (5) could be responsible for the decrement in erythrocytes production.…”

Section: Introductionmentioning

confidence: 99%

Effect of parathyroid hormone on erythropoiesis.

Meytes¹,

Bogin²,

Ma³

et al. 1981

J. Clin. Invest.

224

112

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A B S T R A C T Inhibitors of erythropoiesis have been found in the blood of uremic patients but their nature has not been identified. These patients have excess blood levels of parathyroid hormone (PTH) and it is possible that PTH inhibits erythropoiesis. The present study was undertaken to examine the effect of intact PTH molecules and some of its fragments on human peripheral blood and mouse bone marrow burst-forming units-erythroid (BFU-E), on mouse bone marrow erythroid colony-forming unit (CFU-E), and granulocyte macrophage progenitors (CFU-GM), and evaluate the interaction between PTH and erythropoietin (Ep) on human BFU-E. Intact PTH (1-84 bPTH) in concentrations (7.5-30 U/ml) comparable to those found in blood of uremic patients produced marked and significant (P < 0.01) inhibition of BFU-E and mouse marrow GFU-GM, but not of mouse marrow CFU-E. Inactivation of 1-84 bPTH abolished its action on erythropoiesis. Increasing the concentration of Ep in the media from 0.67 to 1.9 U/ml overcame the inhibitory effect of 1-84 bPTH on BFU-E. The N-terminal fragment of PTH (1-34 bPTH) and 53-84 hPTH had no effect on BFU-E.The results deomonstrate that (a) either the intact PTH molecule or a C-terminal fragment(s) bigger than 53-84 moiety exerts the inhibitory effect on erythropoiesis, and (b) adequate amounts of Ep can overcome this action of PTH. The data provide one possible pathway for the participation of excess PTH in the genesis of the anemia of uremia.

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“…Patients with chronic renal failure usually suffer from a hypoproliferative normochromic normocytic anemnia (1)(2)(3). In addition to hemolysis (4) and blood loss from various sources (5-7), two major factors have been implicated in the mechanism of the anemia of renal insufficiency which may be the cause of the hypoproliferative state of the bone marrow in patients with end-stage renal failure.…”

Section: Introductionmentioning

confidence: 99%

Identification of Spermine as an Inhibitor of Erythropoiesis in Patients with Chronic Renal Failure

Radtke¹,

Rege²,

Lamarche³

et al. 1981

J. Clin. Invest.

149

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A B S T R A C T Fetal mouse liver and normal human bone marrow cell cultures were used for studies on the inhibition of erythroid colony formation (CFU-E) by sera from anemic patients with end-stage renal failure and the polyamine spermine. Sera from each of eight predialysis uremic anemic patients with end-stage renal failure produced a significant (P < 0.001) inhibition of erythroid colony formation in the fetal mouse liver cell cultures when compared to sera from normal human volunteers. In vivo or in vitro dialysis of the uremic sera with a 3,500-dalton exclusion limit membrane removed the inhibitor from uremic sera. The uremic serum dialysate provided by the membrane fractionation was significantly inhibitory in the erythroid cell cultures. When this dialysate was applied to gel filtration chromatography (Bio-Gel P-2) the inhibitor was found to be in the same molecular weight range as [14C]spermine. The polyamine spermine produced a dose-related inhibition of erythroid colony formation (CFU-E) in fetal mouse liver and normal human bone marrow cultures. Thus, the following evidence is provided that the in vitro inhibitor of erythropoiesis found in chronic renal failure patients' sera is identical with the polyamine spermine: (a) the inhibitor and radiolabeled spermine appeared in identical Bio-Gel P-2 effluent fractions; (b) when spermine was added to normal human sera at concentrations reported in sera of uremic patients, and studied in both the fetal mouse liver cell culture and normal human bone marrow cultures, a dose-related inhibition of erythroid colony Heiz W. Radtke was a Postdoctoral Fellow in the Depart-

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Characterization of the anemia associated with chronic renal insufficiency

Cited by 177 publications

References 19 publications

Changes in Hematological Indices in Different Stages of Chronic Renal Failure

Changes in Hematological Indices in Different Stages of Chronic Renal Failure

Effect of parathyroid hormone on erythropoiesis.

Identification of Spermine as an Inhibitor of Erythropoiesis in Patients with Chronic Renal Failure

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