Characterization of Teleost Insulin Receptor Family Members

Greene, Michael W.; Chen, Thomas T.

doi:10.1006/gcen.1999.7293

Cited by 29 publications

(3 citation statements)

References 30 publications

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“…Generally Insulin is implicated in growth, development and reproduction in teleosts [ 50 ] and expression of different insulin receptor genes were studied [ 49 ]. In L rohita expression of insulin receptor b was found down regulated particularly in liver and almost no change in other tissues during preparatory phase as compared to post-spawning , whereas high level of Insulin receptor b mRNA was reported in ovary in rainbow trout [ 51 ]. The role of fibrinogen-γ (FGG) in uterine epithelial cells during normal pregnancy, pseudo-pregnancy and in hormone-treated rats is suggested [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Construction, De-Novo Assembly and Analysis of Transcriptome for Identification of Reproduction-Related Genes and Pathways from Rohu, Labeo rohita (Hamilton)

et al. 2015

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Rohu is a leading candidate species for freshwater aquaculture in South-East Asia. Unlike common carp the monsoon breeding habit of rohu restricts its seed production beyond season indicating strong genetic control over spawning. Genetic information is limited in this regard. The problem is exacerbated by the lack of genomic-resources. We identified 182 reproduction-related genes previously by Sanger-sequencing which were less to address the issue of seasonal spawning behaviour of this important carp. Therefore, the present work was taken up to generate transcriptome profile by mRNAseq. 16GB, 72bp paired end (PE) data was generated from the pooled-RNA of twelve-tissues from pre-spawning rohu using IlluminaGA-II-platform. There were 64.97 million high-quality reads producing 62,283 contigs and 88,612 numbers of transcripts using velvet and oases programs, respectively. Gene ontology annotation identified 940 reproduction-related genes consisting of 184 mainly associated with reproduction, 223 related to hormone-activity and receptor-binding, 178 receptor-activity and 355 embryonic-development related-proteins. The important reproduction-relevant pathways found in KEGG analysis were GnRH-signaling, oocyte-meiosis, steroid-biosynthesis, steroid-hormone biosynthesis, progesterone-mediated oocyte-maturation, retinol-metabolism, neuroactive-ligand-receptor interaction, neurotrophin-signaling and photo-transduction. Twenty nine simple sequence repeat containing sequences were also found out of which 12 repeat loci were polymorphic with mean expected-&-observed heterozygosity of 0.471 and 0.983 respectively. Quantitative RT-PCR analyses of 13-known and 6-unknown transcripts revealed differences in expression level between preparatory and post-spawning phase. These transcriptomic sequences have significantly increased the genetic-&-genomic resources for reproduction-research in Labeo rohita.

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Section: Discussionmentioning

confidence: 99%

Construction, De-Novo Assembly and Analysis of Transcriptome for Identification of Reproduction-Related Genes and Pathways from Rohu, Labeo rohita (Hamilton)

et al. 2015

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“…These studies have shown that the structure, regulation, and functions of IGFs are similar between fish and mammals [21]. Liver tissue contains the greatest concentration of IGF-1 mRNA in trout [22] and gill tissue contains the highest abundance of IGF-1 receptor A (IGF-1RA) mRNA [23]. The type I IGF receptor has been identified in several other tissues in adult fish, including brain, liver, gastrointestinal tract, ovaries, and muscle [24].…”

Section: Insulin-like Growth Factorsmentioning

confidence: 99%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth. Among the possible growth-regulating pathways in vertebrates, components of the somatotropic axis are thought to have the greatest influence. There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish. This includes research into growth hormone, upstream hypothalamic hormones, insulin-like growth factors, and downstream signaling molecules. Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism. Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo. In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis, including emerging research using genetic modified models. These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. somatic growth, endocrine regulation, fish Citation:

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“…Initially thought to be attenuated in brain endothelial cells, receptor-mediated transcytosis occurs in almost all endothelial cells, including those of the brain [ 85 , 86 ]. Several receptors present in the BBB, including the insulin receptor, which shows high amino acid identity between teleosts (particularly rainbow trout) and their human homologs [ 87 ], are capable of inducing receptor-mediated transcytosis [ 88 ]. Transcytosis can occur through clathrin-coated pits during receptor-mediated transcytosis, caveolae during adsorptive-mediated endocytosis, or macropinocytosis involving macropinocytotic vesicles [ 88 ].…”

Section: Tilv Transmission and Cns-invasionmentioning

confidence: 99%

Knowns and unknowns of TiLV-associated neuronal disease

Kembou-Ringert,

Hotio,

Steinhagen

et al. 2024

Virulence

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Tilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field.

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Characterization of Teleost Insulin Receptor Family Members

Cited by 29 publications

References 30 publications

Construction, De-Novo Assembly and Analysis of Transcriptome for Identification of Reproduction-Related Genes and Pathways from Rohu, Labeo rohita (Hamilton)

Construction, De-Novo Assembly and Analysis of Transcriptome for Identification of Reproduction-Related Genes and Pathways from Rohu, Labeo rohita (Hamilton)

Neuroendocrine regulation of somatic growth in fishes

Knowns and unknowns of TiLV-associated neuronal disease

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