Characterization of Tako-tsubo Cardiomyopathy in Spain: Results from the RETAKO National Registry

Gil, Iván J. Núñez; Andrés, Mireia; Delia, Manuel Almendro; Sionís, Alessandro; Martín, Ana; Bastante, Teresa; Soriano, Juan G. Córdoba; Vicente, José; Sucarrats, Sílvia González; Flecha, Alejandro Sánchez-Grande

doi:10.1016/j.rec.2014.07.026

Cited by 27 publications

(24 citation statements)

References 28 publications

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“…The mechanisms resulting in TS are not yet fully understood, but the currently most accepted theories are transient myocardial dysfunction secondary to an exaggerated release of catecholamines, coronary vasospasm and transient microvascular dysfunction[ 3 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The management of acute heart failure is the mainstay of treatment, and in some patients it is necessary to provide support with vasoactive drugs and/or ventricular assistance to achieve hemodynamic stability[ 6 , 7 ]. Once the acute episode has been resolved, a favourable long-term prognosis is generally expected[ 3 ], although recent reports have challenged this notion[ 8 ]. Some series suggest that this entity can have an estimated annual rate of 9.9% major events and 5.6% mortality[ 5 ], in association with a recurrence risk of 5%-10%[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Takotsubo syndrome (TS) was described almost 3 decades ago as an entity mainly affecting older women (post menopause), triggered by emotional stress, with ST-segment elevation on the electrocardiogram and with a characteristic pattern of apical ballooning of the left ventricle[ 1 - 3 ]. However, it is currently recognized that TS may have a more heterogeneous presentation, affecting also men, with different electrocardiographic alterations and diverse patterns of myocardial compromise[ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Takotsubo syndrome - different presentations for a single disease: A case report and review of literature

Fuensalida

Cortés

Gabrielli

et al. 2018

WJC

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We report three cases of Takotsubo syndrome (TS) with atypical myocardial involvement. All three cases were triggered by physical or mental stress, resulting in transient myocardial compromise. However, the clinical presentation, localization and extent of myocardial damage varied in each case, ranging from low-risk acute chest pain to cardiogenic shock with low ejection fraction and dynamic obstruction of the left ventricular outflow tract. These cases outline the range of possible presentations of this rare entity and illustrate atypical forms of TS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Takotsubo syndrome - different presentations for a single disease: A case report and review of literature

Fuensalida

Cortés

Gabrielli

et al. 2018

WJC

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“…Therefore, it is important to bear in mind these two entities in the differential diagnosis. Regarding demographics, although both SCAD and takotsubo syndrome mostly occur in women (circa 90% in both), patients with SCAD are markedly younger in average (50 vs 67–70 years) 60 61…”

Section: Patient Profilementioning

confidence: 99%

Spontaneous coronary artery dissection: contemporary aspects of diagnosis and patient management

et al. 2018

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Spontaneous coronary artery dissection is an increasingly recognised cause of acute coronary syndromes, especially in young and middle-age women. Recognising its particularities and differences with atherosclerotic disease is central for appropriately identifying and approaching these patients. The authors review the current state of knowledge on spontaneous coronary artery dissection and provide practical recommendations for the diagnosis and management of this condition, both in the acute and convalescence phases.

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“…Subsequently, TTS registries were instituted in several countries. In the EU, Spain, Germany, France, and Italy created national registries [6–9]. In Japan, several cohorts and registries were created [10, 11], suggesting the need to collaborate in the creation of an international registry, such as the International Takotsubo (InterTAK) Registry, which was designed as an international, multicenter, prospective and retrospective, and observational study of patients with TTS [12].…”

Section: Introductionmentioning

confidence: 99%

An Emerging Cardiovascular Disease: Takotsubo Syndrome

Moscatelli

Montecucco

Valbusa

et al. 2019

BioMed Research International

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Takotsubo syndrome (TTS) is a recently identified cardiac disease, which is far from being completely known. The aims of this narrative review are to provide a better understanding of the pathophysiological features of TTS and to update clinical findings in order to improve the management of subjects affected by this syndrome (according to the most recent consensus papers issued by the international scientific societies). We based our search on the material obtained via PubMed up to April 2019. The terms used were “Takotsubo Syndrome and Takotsubo cardiomyopathy” in combination with “heart failure, pathophysiology, complications, diagnosis, and treatment.” TTS is a reversible form of ventricular dysfunction usually characterized by akinesia of the apex in the absence of obstructive coronary artery disease. In its initial phase, TTS may be indistinguishable from AMI and is usually triggered by a sudden emotional/physical stressor which abruptly increases catecholamine levels. However, the mechanisms by which catecholamines or other unidentified molecules can cause myocardial dysfunction is unknown. In-hospital stay may be hampered by various life-threatening complications, while data on long-term survival remain scarce and unclear. Furthermore, TTS may sometimes recur. We believe that TTS is clearly a much more complex condition than previously thought. Much remains to be discovered about its pathophysiologic mechanisms, the role of the link between the heart and brain and that of triggering factors and gender, and the reasons why this syndrome displays different phenotypes and sometimes recurs. Undoubtedly, preliminary evidence from pathophysiological studies (mainly genetic studies) has shown promising advances. However, prospective randomized clinical trials are still needed in order to identify and to tailor the best medical treatments for TTS patients.

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Characterization of Tako-tsubo Cardiomyopathy in Spain: Results from the RETAKO National Registry

Cited by 27 publications

References 28 publications

Takotsubo syndrome - different presentations for a single disease: A case report and review of literature

Takotsubo syndrome - different presentations for a single disease: A case report and review of literature

Spontaneous coronary artery dissection: contemporary aspects of diagnosis and patient management

An Emerging Cardiovascular Disease: Takotsubo Syndrome

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