Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis

Gilger, Brian C.; Malok, Emily; Cutter, Katherine V.; Stewart, Tammy; Horohov, David W.; Allen, Julie K.

doi:10.1016/s0165-2427(99)00082-3

Cited by 111 publications

(114 citation statements)

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“…1399, 2012 equinos, e representa a doença mais devastadora para a indústria equina em todo o mundo (Keller e Hendrix, 2005). A natureza progressiva da URE é responsável pelo subsequente desenvolvimento de catarata, adesões intraoculares, phthisis bulbi e cegueira, e em associação com as dificuldades encontradas no tratamento são as maiores causas de eutanásia em cavalos, realizadas por segurança ou razões éticas e humanitárias (Deeg et al, 2001;Gilger et al, 1999) . Acredita-se que a URE tenha uma importante parcela imunomediada na sua patogênese (Deeg et al, 2001), e tem sido estudada com intensidade pela semelhança com as uveítes recorrentes em seres humanos, como por exemplo a uveíte intermediária ou a doença de Behçet´s (Gilger et al, 2000).…”

Section: Desenvolvimentounclassified

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2012

Pubvet

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ResumoDoenças do segmento posterior do bulbo do olho são responsáveis pela maioria dos casos de cegueira irreversível no mundo inteiro e, até o momento, BIONDI, F. et al. Implantes poliméricos intraoculares de fármacos na medicina veterinária, revisão de literatura e relato de um caso. PUBVET, Londrina, V. 6, N. 23, Ed. 210, Art. 1399, 2012 apresentam sucesso terapêutico limitado devido à dificuldade de penetração dos fármacos neste local. Na medicina veterinária, as doenças oculares crônicas apresentam frequente insucesso terapêutico por conta da frequência e via de administração, além do alto custo das medicações. Visando a obtenção de níveis terapêuticos adequados de fármacos por períodos prolongados e a diminuição de efeitos colaterais indesejados, alguns sistemas de liberação poliméricos de implantação intraocular estão sendo investigados. Eles são preparados na forma de implantes a partir de polímeros que podem ser biodegradáveis ou não biodegradáveis, e pretendem revolucionar a oftalmologia humana e veterinária, aumentando o conforto do paciente e a eficácia medicamentosa no tratamento de doenças até o momento tidas como irreversíveis por conta das dificuldades terapêuticas á elas relacionadas.Palavras-chave: doenças oculares; medicação intraocular; sistemas de liberação. Polymeric implants for intraocular administration of drugs inveterinary medicine -review of the literature and report of a case AbstractDiseases of the posterior segment of the eye are responsible for most cases of irreversible blindness, and until at the present moment, have limited therapeutic success due to the difficulty of penetration of drugs in this site. In veterinary medicine, chronic eye diseases are often frustrating to treat due to the frequency and route of administration, besides the high cost of the drugs involved. In order to obtain therapeutic levels of these drugs for prolonged periods and to promote reduction of unwanted side effects, some polymeric delivery systems designed for intraocular implantation are currently being investigated. They are prepared in the form of implants from polymers that can be classified in biodegradable or nonbiodegradable, and are aimed to revolutionize medical and veterinary ophthalmology, increasing patient comfort BIONDI, F. et al. Implantes poliméricos intraoculares de fármacos na medicina veterinária, revisão de literatura e relato de um caso. PUBVET, Londrina, V. 6, N. 23, Ed. 210, Art. 1399, 2012 and effectiveness of drugs in the treatment of diseases, which are so far regarded as irreversible because of the difficulties therapies related to them.Keywords: eye diseases; intraocular medication; systems release. INTRODUÇÃOAs doenças oculares acometem as mais diversas espécies, incluindo a espécie humana, podendo causar intenso desconforto, comprometimento da acuidade visual e, por fim, cegueira. Sabe-se que as doenças do segmento posterior do olho são responsáveis pela maioria dos casos de cegueira irreversível no mundo (Fialho e Cunha Júnior, 2007). Em seres humanos, crescem os caso...

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Section: Desenvolvimentounclassified

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2012

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“…Moreover, injection of IRBP with complete Freund's adjuvant induced a disease similar to ERU (7). Gilger et al (11) observed high IL-2 and gamma interferon and low IL-4 mRNA levels in the iris and ciliary body and a predominance of CD4 ϩ Th1 cells in uveitic fluids. They concluded that the intraocular immune response was Th1, most likely associated with delayed-type hypersensitivity (DTH) reactivity to self antigens in the uveal tract.…”

Section: Vol 73 2005mentioning

confidence: 99%

“…Once induced, ACAID is long lasting, and so its effects would be expected to persist into the later stages of ERU. Although direct Leptospira-mediated injury to the eye structure cannot be ruled out in explaining the pathogenic mechanisms of ERU, there is a growing body of evidence that autoimmune responses to ocular tissue components play a significant role in pathogenesis (6,11,38,39,40). Cross-reactivity between leptospiral lysates and the cornea or lens has been previously reported (28,38).…”

Section: Vol 73 2005mentioning

confidence: 99%

“…They concluded that the intraocular immune response was Th1, most likely associated with delayed-type hypersensitivity (DTH) reactivity to self antigens in the uveal tract. They also observed that peripheral blood lymphocytes of horses with ERU did not exhibit a Th1 response, and they concluded that the local ocular and systemic T-lymphocyte populations were different (11).…”

Section: Vol 73 2005mentioning

confidence: 99%

“…CD4 ϩ T lymphocytes are the most abundant infiltrating cells in the anterior uveal tracts of uveitic horses. The T-lymphocyte response in such horses has a Th1 bias based on quantitative reverse transcription-PCR (RT-PCR), which showed significantly greater interleukin-2 (IL-2)/gamma interferon-than IL-4-specific mRNA (11). Also, peripheral blood leukocytes of chronically uveitic horses do not exhibit a Th1 response, consistent with an independent local response (11).…”

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LruA and LruB, Novel Lipoproteins of PathogenicLeptospira interrogansAssociated with Equine Recurrent Uveitis

et al. 2005

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Uveitis in horses induced by interphotoreceptor retinoid‐binding protein is similar to the spontaneous disease

et al. 2002

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Equine recurrent uveitis (ERU) is an inflammatory eye disease with high similarity to uveitis in man. It is the only spontaneous animal model for uveitis and the most frequent eye disease in horses affecting up to 10% of the population. To further investigate the pathophysiology of ERU we now report the establishment of an inducible uveitis model in horses. An ERU‐like disease was elicited in seven out of seven horses by injection of interphotoreceptor retinoid‐binding protein (IRBP) in complete Freund's adjuvant. Control horses did not develop uveitis. The disease model is characterized by a highly reproducible disease course and recurrent episodes with an identical time course elicited in all horses by repeated IRBP injections. The histology revealed the formation of lymphoid follicle‐like structures in the eyes and an intraocular infiltration dominated by CD3+ lymphocytes, morphological patterns typical for the spontaneous disease. Antigen‐specific T cell proliferation of PBL was monitored prior to clinical uveitis and during disease episodes. An initial T cell response to IRBP‐derived peptides was followed by epitope spreading to S‐antigen‐derived peptides in response to subsequent immunizations. Thus, horse experimental uveitis represents a valuable disease model for comparative studies with the spontaneous disease and the investigation of immunomodulatory therapeutic approaches after onset of the disease.

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Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis

Cited by 111 publications

References 13 publications

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LruA and LruB, Novel Lipoproteins of PathogenicLeptospira interrogansAssociated with Equine Recurrent Uveitis

Uveitis in horses induced by interphotoreceptor retinoid‐binding protein is similar to the spontaneous disease

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