Characterization of surface oxide films on titanium and adhesion of osteoblast

Feng, Bo; Weng, Jie; Yang, Bang Cheng; Qu, Shao Xing; Zhang, X.D.

doi:10.1016/s0142-9612(03)00366-1

Cited by 365 publications

(274 citation statements)

References 32 publications

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“…This is hypothesized to stem from its higher surface energy, which correlates well with the contact angle measurements. It is, however, interesting to note such high degree of apatite formation on substrates with high Ag content and poor TiO 2 crystallinity, which would generally result in less surface hydroxyl groups and less active sites available for apatite nucleation [53]. The presence of Ag peaks in the GI-XRD spectra of precipitated HA (Fig.…”

Section: Discussionmentioning

confidence: 99%

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

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Growing demand for orthopedic and dental implants has spurred researchers to develop multifunctional coatings, combining tissue integration with antibacterial features. A possible strategy to endow titanium (Ti) with antibacterial properties is by incorporating silver (Ag), but designing a structure with adequate Ag + release while maintaining biocompatibility has been shown difficult. To further explore the composition-structure-property relationships between Ag and Ti, and its effects against bacteria, this study utilized a combinatorial approach to manufacture and test a single sample containing a binary Ag-Ti oxide gradient. The sample, sputter deposited in a reactive (O 2 ) environment using a custom built combinatorial physical vapor deposition (PVD) system, was shown to be effective against Staphylococcus aureus with viability reductions ranging from 17 to above 99 %, depending on amount of Ag + released from its different parts. The Ag content along the gradient ranged from 35 to 62 wt%, but it was found that structural properties such as varied porosity and degree of crystallinity, rather than amount of incorporated Ag governed the Ag + release and resulting antibacterial activity. The coating also demonstrated in vitro apatite forming abilities, where structural variety along the sample was shown to alter the hydrophilic behavior, with degree of hydroxyapatite (HA) deposition varying accordingly. By means of combinatorial synthesis, a single gradient sample was able to display intricate compositional and structural features affecting its biological response, which would otherwise require a series of coatings. The current findings suggest that future implant coatings incorporating Ag as an antibacterial agent could be structurally enhanced to better suit clinical requirements.

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Section: Discussionmentioning

confidence: 99%

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

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“…On the other hand, β-Ca 2 SiO 4 scaffolds had rough surface and pores on the struts, which might be the gas release that induced from the reaction during sintering process [2,3]. In fact, the rough surface is benefit for cell adhesion, differentiation and thereby formation of cell matrix [45–47]. Therefore, the 3D-printed preceramic polymer-derived scaffolds had a desirable phase of β-Ca 2 SiO 4 and rough surface, which might be promising for bone tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Liu

et al. 2018

Science and Technology of Advanced Materials

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Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca2SiO4 scaffolds have been successfully fabricated from preceramic resin loaded with CaCO3 active filler by 3D printing. The fabricated β-Ca2SiO4 scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca2SiO4 scaffolds derived from preceramic resin and CaCO3 active fillers would be promising candidates for bone tissue engineering.

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“…There are two kinds of hydroxyl groups on the outermost surfaces of Ti, negatively charged acidic hydroxyl groups and positively charged basic hydroxyl groups, which play important roles in protein adsorption 32) . Feng et al 33) showed that at the initial stage of cell culture, the basic hydroxyl groups promote chemical interaction between osteoblasts and the Ti surface, indicating that the basic hydroxyl groups probably play a more important role in the bioactivity of Ti than do the acidic hydroxyl groups. In general, most proteins are negatively charged in a neutral environment.…”

Section: Discussionmentioning

confidence: 99%

Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells

et al. 2015

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The purpose of this study was to investigate the influence of superhydrophilic treatments of titanium on the behavior of osteoblastlike cells. Superhydrophilic specimens were prepared with sandblast and acid-etching (DW), oxygen plasma (Plasma) and ultraviolet light (UV), and were stored in distilled water for 3 days immediately after these treatments. Specimens stored in air for 3 weeks were used as a control Air group. Initial cell attachment, proliferation, alkaline phosphatase activity, and osteocalcin secretion of mouse osteoblast-like cells MC3T3-E1 were enhanced more on superhydrophilic groups than were Air specimens. On confocal laser scanning microscope images of cell morphology, the expression of actin filaments was observed on the superhydrophilic groups, whereas relatively little actin filament expression was seen on the Air surfaces on all culture periods. These results indicate that DW, Plasma, or UV treatment has potential for the creation and maintenance of superhydrophilic surfaces and the enhancement of the initial attachment, proliferation, and differentiation of osteoblast-like cells.

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Characterization of surface oxide films on titanium and adhesion of osteoblast

Cited by 365 publications

References 32 publications

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells

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Characterization of surface oxide films on titanium and adhesion of osteoblast

Cited by 365 publications

References 32 publications

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

3D printed porous β-Ca2SiO4scaffolds derived from preceramic resin and their physicochemical and biological properties

Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteoblast-like cells

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3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties