Characterization of Squamous Cell Cancers of the Vulvar Anterior Fourchette by Human Papillomavirus, p16INK4a, and p53

Reuschenbach, Miriam; Roos, J O; Panayotopoulos, Dimitrios; Baldus, Stephan; Hg, Schnürch; Berger, Annemarie; Petry, Karl Ulrich; Dürst, Matthias; Seiz, Mirjam; Doeberitz, Magnus von Knebel; Hampl, Monika

doi:10.1097/lgt.0b013e31826f2b2b

Cited by 31 publications

(20 citation statements)

References 14 publications

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“…The variety in histopathologic features in dVIN is diverse ranging from atrophic to verruciform variants (10,12). Positive p53 staining might be helpful to differentiate between reactive changes and dVIN but not all cases of dVIN show p53 positivity in neoplastic cells which is in line with findings observed in VSCCs (24). The paradox that dVIN is less commonly diagnosed than HPV related VIN while most of the VSCCs are HPV negative has been ascribed to underdiagnoses of dVIN but it has also been hypothesized that the interval between HPV-negative dVIN and VSCC is much shorter than the interval between HPV-induced VIN and VSCC, The latter hypothesis is supported by the finding that women diagnosed with HPV-related VIN are much younger than women with dVIN (11).…”

Section: Cancer Epidemiol Biomarkers Prev; 25(8) August 2016supporting

confidence: 67%

Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma

Bleeker

Visser²,

Overbeek³

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

206

157

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Background: The association between lichen sclerosus and vulvar squamous cell carcinoma (VSCC) has long been recognized, but large epidemiologic studies are lacking.Methods: Data of women diagnosed with vulvar pathology in the Netherlands were retrieved from the Dutch Pathology Registry. All vulvar pathology reports of this historical cohort were reviewed to construct a research database, including 3,038 women with lichen sclerosus diagnosed between 1991 and 2011. The incidence rate of lichen sclerosus and the cumulative incidence of VSCC among women with lichen sclerosus were estimated.Results: Between 1991 and 2011, the incidence rate of lichen sclerosus increased from 7.4 to 14.6 per 100,000 woman-years. The median age at time of lichen sclerosus diagnosis was 59.8 years and the cumulative VSCC incidence was 6.7%. The 10-year VSCC incidence in women with lichen sclerosus was associated

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Section: Cancer Epidemiol Biomarkers Prev; 25(8) August 2016supporting

confidence: 67%

Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma

Bleeker

Visser²,

Overbeek³

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

206

157

View full text Add to dashboard Cite

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“…Positive HPV status was defined by concomitant positivity for high-risk HPV-DNA detection together with strong, diffuse p16 INK4a expression in both nucleus and cytoplasm of at least 70% of tumour cells, as this is considered to indicate truly HPV-transformed lesions (Klussmann et al , 2003a; Reuschenbach et al , 2013; Prigge et al , 2015, 2016). Briefly, DNA extracted from 10 μ m FFPE tissue sections using the DNeasy Blood and Tissue Kit (Qiagen, Hilden, Germany), corresponding to ∼10 × 10 mm tumour tissue, was analysed for HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82) by PCR followed by bead-based hybridisation (Luminex Technology, Multimetrix, Progen, Heidelberg, Germany) (Schmitt et al , 2006; Prigge et al , 2015).…”

Section: Methodsmentioning

confidence: 99%

Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer

et al. 2017

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Background:Upfront surgery is a valuable treatment option for oropharyngeal squamous cell carcinoma (OPSCC) and risk stratification is emerging for treatment de-escalation in human papillomavirus (HPV)-related OPSCC. Available prognostic models are either based on selected, mainly non-surgically treated cohorts. Therefore, we investigated unselected OPSCC treated with predominantly upfront surgery.Methods:All patients diagnosed with OPSCC and treated with curative intent between 2000 and 2009 (n=359) were included. HPV association was determined by HPV-DNA detection and p16INK4a immunohistochemistry. Predictors with significant impact on overall survival (OS) in univariate analysis were included in recursive partitioning analysis.Results:Risk models generated from non-surgically treated patients showed low discrimination in our cohort. A new model developed for unselected patients predominantly treated with upfront surgery separates low-, intermediate- and high-risk patients with significant differences in 5-year OS (86%, 53% and 19%, P<0.001, respectively). HPV status is the most important parameter followed by T-stage in HPV-related and performance status in HPV-negative OPSCC. HPV status and ECOG remained important parameters in risk models for patients treated with or without surgery.Conclusions:Regardless of treatment strategies, HPV status is the strongest predictor of survival in unselected OPSCC patients. The proposed risk models are suitable to discriminate risk groups in unselected OPSCC patients treated with upfront surgery, which has substantial impact for design and interpretation of de-escalation trials.

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“…Unfortunately, Woelber et al and Nica et al studies had not speci ed the location of the tumors, if they were midline or lateral. 7,8,12 Over the past decade, there is an increasing trend for midline vulvar cancer [23][24][25][26] . This was con rmed with the majority cases in our recent study located at anterior fourchette.…”

Section: Discussionmentioning

confidence: 99%

The Possibility of Contralateral Non-Sentinel Groin Node’s Metastasis in Early Primary Vulvar Cancer Women After Unilateral Sentinel Node’s Metastasis: A Single Center Evaluation in University Hospital of Düsseldorf

Winarno¹,

Mondal²,

Martignoni³

et al. 2020

Preprint

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Background: Sentinel node biopsy (SLNB) technique in unifocal vulvar cancer (diameter of < 4cm) and unsuspicious groin lymph nodes, the morbidity rate of patients has significantly decreased all over the world. In contrast to SLNB, bilateral inguinofemoral lymphadenectomy (IFL) has been associated with increased risk of common morbidities. Current guidelines (NCCN, ESGO, RCOG, and German) suggest that in cases of metastasis of unilateral SLNB, groin node dissection with IFL, should be performed bilaterally. However, a publication by Woelber et al. 0% (p=0/28) and Nica et al. 5.3% (p=1/19) contradicted the current guideline. Methods: A single-center analysis conducted in the University Hospital of Dusseldorf, evaluating vulvar cancer patients treated with SLNB retrospectively from 2002 to 2018. Result, discussion and conclusion: Current guideline for bilateral IFL should remain as the standard management because 22.2% women (n=4/18) had contralateral IFL groin metastasis after unilateral SLNB metastasis initially. The depth of tumor infiltrating cells was correlated significantly and positively with the incidence rate of groin metastasis (p=0.0038). Therefore, it is an indication for bilateral IFL.

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Characterization of Squamous Cell Cancers of the Vulvar Anterior Fourchette by Human Papillomavirus, p16INK4a, and p53

Abstract: Different types of vulvar cancers can be found in squamous cell tumors of the anterior fourchette, similar to the finding in vulvar cancers from other locations and to what has previously been reported for vulvar squamous cell carcinomas in general.

Cited by 31 publications

References 14 publications

Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma

Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma

Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer

The Possibility of Contralateral Non-Sentinel Groin Node’s Metastasis in Early Primary Vulvar Cancer Women After Unilateral Sentinel Node’s Metastasis: A Single Center Evaluation in University Hospital of Düsseldorf

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