Characterization of some ungrouped viruses

Mekki, A.A. El; Nieuwenhuysen, Paul; Groen, G van der; Pattyn, S. R.

doi:10.1016/0035-9203(81)90416-8

Cited by 18 publications

(24 citation statements)

References 8 publications

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“…This is the first comprehensive effort to place unclassified, putative arboviruses in taxa since the studies of E1 Mekki et al [15]. Summarized information for many viruses, classified and unclassified, is presented in the International Catalogue of Arboviruses [1] and should be referred to for detailed information not included in our paper.…”

Section: Discussionmentioning

confidence: 99%

Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in familiesArenaviridae, Paramyxoviridae, orPoxviridae

Zeller

Karabatsos²,

Calisher³

et al. 1989

Archives of Virology

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During approximately 35 years, investigators in various laboratories studying arbovirus ecology and epidemiology accumulated many virus isolates, more than 60 of which were not characterized or placed in taxa. By a combination of electron microscopic and antigenic studies we collected information sufficient to provisionally classify 60 isolates. Electron microscopic observations suggest that 20 are members of the virus family Bunyaviridae, 20 Rhabdoviridae, 14 Reoviridae, one Togaviridae, one Paramyxoviridae (Mapuera virus, from a bat), and one Poxviridae (Yoka virus, from mosquitoes). Serologic studies provided evidence sufficient to place some of these viruses in recognized antigenic groups, within families and genera, and to establish new antigenic groups and taxa for others. Three viruses were found to have morphologic and morphogenetic characteristics consistent with those of members of the family Arenaviridae: Quaranfil virus, a human pathogen, Johnston Atoll virus, isolated from birds and ticks, and Araguari virus, isolated from an opossum. This, the first in a series of three papers, described methods used for these investigations and also presents descriptions of viruses provisionally placed in the families Arenaviridae, Paramyxoviridae, or Poxviridae. Descriptions of viruses provisionally placed in families Bunyaviridae and Reoviridae are published in the second and third papers, respectively. Viruses of the family Rhabdoviridae have been described separately.

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Section: Discussionmentioning

confidence: 99%

Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in familiesArenaviridae, Paramyxoviridae, orPoxviridae

Zeller

Karabatsos²,

Calisher³

et al. 1989

Archives of Virology

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“…collected in Botambi, Central African Republic (Digoutte & Germain, 1985;El Mekki et al, 1981;Zeller et al, 1989). The virus was isolated by intracerebral inoculation of suckling mice (Digoutte, 1978).…”

mentioning

confidence: 99%

Genomic characterization of Sebokele virus 1 (SEBV1) reveals a new candidate species among the genus Parechovirus

Joffret

Bouchier

Grandadam

et al. 2013

Journal of General Virology

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We determined the genomic features and the taxonomic classification of Sebokele virus 1 (SEBV1), a previously unclassified arbovirus isolated in 1972 from rodents collected in Botambi, Central African Republic. The complete genome sequence was obtained using a deep sequencing approach (Illumina technology) and dedicated bioinformatics workflows for data analysis. Molecular analysis identified SEBV1 as a picornavirus, most closely related to Ljungan viruses of the genus Parechovirus. The genome has a typical Ljungan virus-like organization, including the presence of two unrelated 2A protein motifs. Phylogenetic analysis confirmed that SEBV1 belongs to the parechovirus phylogroup and was most closely related to the Ljungan virus species. However, it appeared clearly distinct from all members of this phylogroup, suggesting that it represents a novel species of the genus Parechovirus.

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“…An incompatibility of tick-derived arboviruses with mosquito physiology has also been observed for other related tick-associated viruses such as Quaranfil and Johnston Atoll viruses (4,5). Based on physicochemical and morphological features reported for UPOV, the viruses of the Upolu virus serogroup (UPOV and ABV) were tentatively placed into the family Bunyaviridae as two species not assigned to one of the genera of this family of enveloped, negative-sense, single-stranded RNA viruses with tripartite genomes (3,6). Here, we report data clearly demonstrating that UPOV and ABV are orthomyxoviruses.…”

mentioning

confidence: 85%

“…UPOV and ABV do not propagate in mosquitoes but replicate in mammalian cell cultures (African green monkey kidney [Vero], baby hamster kidney [BHK], Madin-Darby canine kidney [MDCK], and human embryonic kidney 293 [HEK 293] cells) (2,3). An incompatibility of tick-derived arboviruses with mosquito physiology has also been observed for other related tick-associated viruses such as Quaranfil and Johnston Atoll viruses (4,5).…”

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confidence: 99%

Upolu virus and Aransas Bay virus, Two Presumptive Bunyaviruses, Are Novel Members of the Family Orthomyxoviridae

Briese

Chowdhary

Rosa

et al. 2014

J Virol

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Emerging and zoonotic pathogens pose continuing threats to human health and ongoing challenges to diagnostics. As nucleic acid tests are playing increasingly prominent roles in diagnostics, the genetic characterization of molecularly uncharacterized agents is expected to significantly enhance detection and surveillance capabilities. We report the identification of two previously unrecognized members of the family Orthomyxoviridae, which includes the influenza viruses and the tick-transmitted Thogoto and Dhori viruses. We provide morphological, serologic, and genetic evidence that Upolu virus (UPOV) from Australia and Aransas Bay virus (ABV) from North America, both previously considered potential bunyaviruses based on electron microscopy and physicochemical features, are orthomyxoviruses instead. Their genomes show up to 68% nucleotide sequence identity to Thogoto virus (segment 2; ϳ74% at the amino acid level) and a more distant relationship to Dhori virus, the two prototype viruses of the recognized species of the genus Thogotovirus. Despite sequence similarity, the coding potentials of UPOV and ABV differed from that of Thogoto virus, instead being like that of Dhori virus. Our findings suggest that the tick-transmitted viruses UPOV and ABV represent geographically distinct viruses in the genus Thogotovirus of the family Orthomyxoviridae that do not fit in the two currently recognized species of this genus. IMPORTANCE Upolu virus (UPOV) and Aransas Bay virus (ABV) are shown to be orthomyxoviruses instead of bunyaviruses, as previously thought.Genetic characterization and adequate classification of agents are paramount in this molecular age to devise appropriate surveillance and diagnostics. Although more closely related to Thogoto virus by sequence, UPOV and ABV differ in their coding potentials by lacking a proposed pathogenicity factor. In this respect, they are similar to Dhori virus, which, despite the lack of a pathogenicity factor, can cause disease. These findings enable further studies into the evolution and pathogenicity of orthomyxoviruses.

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Characterization of some ungrouped viruses

Cited by 18 publications

References 8 publications

Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in familiesArenaviridae, Paramyxoviridae, orPoxviridae

Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in familiesArenaviridae, Paramyxoviridae, orPoxviridae

Genomic characterization of Sebokele virus 1 (SEBV1) reveals a new candidate species among the genus Parechovirus

Upolu virus and Aransas Bay virus, Two Presumptive Bunyaviruses, Are Novel Members of the Family Orthomyxoviridae

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