Characterization of Some Master Mg-X System (Ca, Mn, Zr, Y) Alloys Used in Medical Applications

Lupescu, Ștefan; Istrate, Bogdan; Munteanu, Corneliu; Minciună, Mirabela Georgiana; Focsaneanu, Sergiu; Earar, Kamel

doi:10.37358/rc.17.6.5664

Cited by 22 publications

(13 citation statements)

References 19 publications

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“…The values of the longitudinal elastic modulus of the Ti-Mo alloys compared to the classical ones are shown in figure 5. The alloys of the β type have much lower values of the longitudinal elastic modulus compared to the α or α+ β alloys, which is why research and their development is a priority for researchers [7,11,[33][34][35].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Biocompatible Titanium Alloys used in Medical Applications

Bălțatu¹,

Tugui²,

Perju³

et al. 2019

Rev. Chim.

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At global level, there is a continuing concern for the research and development of alloys for medical and biomedical applications. Metallic biomaterials are used in various applications of the most important medical fields like orthopedic, dental and cardiovascular. The main metallic biomaterials used in human body are stainless steels, Co-based alloys and Ti-based alloys. Titanium and its alloys are of greater interest in medical applications because they exhibit characteristics required for implant materials, namely, good mechanical properties (less elasticity modulus than stainless steel or CoCr alloys, fatigue strength, high corrosion resistance), high biocompatibility. The aim of this review is to describe and compare the main characteristics (mechanical properties, corrosion resistance and biocompatibility) for latest research of nontoxic Ti alloys biomaterials used for medical field.

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Section: Mechanical Propertiesmentioning

confidence: 99%

“…The most common and known are metallic biomaterials. This category includes pure metals, metal alloys and intermetallic compounds [5][6][7], according to table 1.…”

mentioning

confidence: 99%

Biocompatible Titanium Alloys used in Medical Applications

Bălțatu¹,

Tugui²,

Perju³

et al. 2019

Rev. Chim.

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“…The manufacturing process of the experimental alloys used master alloys procured from Hunan China Co. [41,42] with the mass percentages shown in Table 1. The Mg-based alloys were obtained through a classical melting process using an induction furnace in an Ar-protected environment in a 675-700 • C temperature field for 30minutes from a square section of the initial materials, as in previous research [43].…”

Section: Obtaining Themagnesium With Calcium and Gadolinium Alloys' Structure And Chemical Composition Investigationsmentioning

confidence: 99%

“…Magnesium and Mg-based master alloy weight percentages[41,42]. Initial materials masses used formetal charges in order to obtain the experimental samples.…”

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confidence: 99%

Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys

et al. 2021

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The subject of Mg-based biodegradable materials, used for medical applications, has been extensively studied throughout the years. It is a known fact that alloying Mg with biocompatible and non-toxic elements improves the biodegradability of the alloys that are being used in the field of surgical applications. The aim of this research is to investigate the aspects concerning the microstructure, electrochemical response (corrosion resistance) and in vitro cytocompatibility of a new experimental Mg-based biodegradable alloy—Mg–0.5%Ca with controlled addition of Gd as follows: 0.5, 1.0, 1.5, 2.0 and 3.0 wt.%—in order to establish improved biocompatibility with the human hard and soft tissues at a stable biodegradable rate. For this purpose, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM) and X-ray diffraction (XRD) were used for determining the microstructure and chemical composition of the studied alloy and the linear polarization resistance (LPR) method was used to calculate the corrosion rate for the biodegradability rate assessment. The cellular response was evaluated using the 3-(4,5-dimethyltiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test followed by fluorescence microscopy observation. The research led to the discovery of a dendritic α-Mg solid solution, as well as a lamellar Mg2Ca and a Mg5Gd intermetallic compound. The in vivo tests revealed 73–80% viability of the cells registered at 3 days and between 77 and 100% for 5 days, a fact that leads us to believe that the experimental studied alloys do not have a cytotoxic character and are suitable for medical applications.

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“…The master alloys used for sample manufacturing were purchased from Hunan China Co., Hunan, China [51,52] and they have the chemical composition presented in Table 1. The casting of Mg alloys was performed in an induction furnace (Inductro S.A., Bucharest, Romania) with an inert Ar5.0 protective atmosphere at a temperature of 680-690 • C for 30 min using rectangular bars as raw materials.…”

Section: Synthesis Of Mg-ca-y Alloys Morphological and Structural Anmentioning

confidence: 99%

Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

et al. 2020

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In recent years, biodegradable Mg-based materials have been increasingly studied to be used in the medical industry and beyond. A way to improve biodegradability rate in sync with the healing process of the natural human bone is to alloy Mg with other biocompatible elements. The aim of this research was to improve biodegradability rate and biocompatibility of Mg-0.5Ca alloy through addition of Y in 0.5/1.0/1.5/2.0/3.0wt.%. To characterize the chemical composition and microstructure of experimental Mg alloys, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM), and X-ray diffraction (XRD) were used. The linear polarization resistance (LPR) method was used to calculate corrosion rate as a measure of biodegradability rate. The cytocompatibility was evaluated by MTT assay (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide) and fluorescence microscopy. Depending on chemical composition, the dendritic α-Mg solid solution, as well as lamellar Mg2Ca and Mg24Y5 intermetallic compounds were found. The lower biodegradability rates were found for Mg-0.5Ca-2.0Y and Mg-0.5Ca-3.0Y which have correlated with values of cell viability. The addition of 2–3 wt.%Y in the Mg-0.5Ca alloy improved both the biodegradability rate and cytocompatibility behavior.

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Characterization of Some Master Mg-X System (Ca, Mn, Zr, Y) Alloys Used in Medical Applications

Cited by 22 publications

References 19 publications

Biocompatible Titanium Alloys used in Medical Applications

Biocompatible Titanium Alloys used in Medical Applications

Microstructural, Electrochemical and In Vitro Analysis of Mg-0.5Ca-xGd Biodegradable Alloys

Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys

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