Characterization of silkworm larvae growth and properties of silk fibres after direct feeding of copper or silver nanoparticles

Cheng, Longdi; Huang, Haohai; Chen, Shaoyong; Wang, Wenlu; Dai, Fangyin; Zhao, Hongping

doi:10.1016/j.matdes.2017.04.096

Cited by 65 publications

(52 citation statements)

References 42 publications

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“…Feeding can be potentially used for the large-scale production of silk with enhanced properties. Using this approach, a variety of fluorescent dyes or functional nanomaterials, such as graphene, carbon nanotubes, copper nanoparticles, silver nanoparticles, and titanium dioxide can be intrinsically incorporated into silk fibers, by simply nourishing silkworms with special diets that contain these specific materials [83][84][85][86]. In addition, functional molecules can also be incorporated into silk via doping.…”

Section: Processing Of Sf Biomaterialsmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

et al. 2019

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Since it was first discovered, thousands of years ago, silkworm silk has been known to be an abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin (SF), the main protein of silkworm silk, has not been limited to the textile industry but has been further extended to various high-tech application areas, including biomaterials for drug delivery systems and tissue engineering. The outstanding mechanical properties of SF, including its facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization have allowed its use for innovative applications. In this review, we describe the structure, composition, general properties, and structure-properties relationship of SF. In addition, the methods used for the fabrication and modification of various materials are briefly addressed. Lastly, recent applications of SF-based materials for small molecule drug delivery, biological drug delivery, gene therapy, wound healing, and bone regeneration are reviewed and our perspectives on future development of these favorable materials are also shared.

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Section: Processing Of Sf Biomaterialsmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

et al. 2019

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“…Hence, 1.25 wt% was chosen as the maximum content of CNDs in this study to save the additional costs of further scale production and avoid any adverse effect of excessive CNDs on silkworms and silks [23]. Similar to other modified silks from silkworms fed silver nanoparticle [29], threonine [30], or nanohydroxyapatite powers [31], the mechanical properties of CNDs-modified silks were more variable than those of control silk. This may be attributed to the effect of exogenous addition on silkworm's spinning behavior including spinning speed, which significantly determines the performance of silk [32].…”

Section: Mechanical Properties Of Cnds-modified Silksmentioning

confidence: 99%

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

et al. 2019

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HIGHLIGHTS • Intrinsically, super-strong fluorescent silk was fabricated via feeding Bombyx mori silkworms with carbon nanodots. • The multi-functional silks showed no cytotoxicity to Schwann cells and exhibited great potential in bioimaging. • The reinforcing mechanism of multi-functional silks was proposed. ABSTRACT Fluorescent silk is fundamentally important for the development of future tissue engineering scaffolds. Despite great progress in the preparation of a variety of colored silks, fluorescent silk with enhanced mechanical properties has yet to be explored. In this study, we report on the fabrication of intrinsically super-strong fluorescent silk by feeding Bombyx mori silkworm carbon nanodots (CNDs). The CNDs were incorporated into silk fibroin, hindering the conformation transformation, confining crystallization, and inducing orientation of mesophase. The resultant silk exhibited super-strong mechanical properties with breaking strength of 521.9 ± 82.7 MPa and breaking elongation of 19.2 ± 4.3%, improvements of 55.1% and 53.6%, respectively, in comparison with regular silk. The CNDs-reinforced silk displayed intrinsic blue fluorescence when exposed to 405 nm laser and exhibited no cytotoxic effect on cells, suggesting that multi-functional silks would be potentially useful in bioimaging and other applications.

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“…These fibres are not stronger when compared with their rival spider silk, but have certain advantages over them as they are domesticated easily and can produce silk in large amounts [1,3]. Modification of silkworms and silk fibres is an active research area where in vivo and in vitro transformations are explored to improve the silk yield, fibre properties and resistance towards viral diseases [1,[4][5][6][7][8]. For instance, modification of silk fibres with nanoparticles like Ag, TiO 2 and TiO 2 @Ag are examples of in vitro studies and changing the diet of silkworms with the addition of dyes and metallic elements like TiO 2 are some examples of in vivo studies [1,2,5,6,9].…”

Section: Introductionmentioning

confidence: 99%

“…Modification of silkworms and silk fibres is an active research area where in vivo and in vitro transformations are explored to improve the silk yield, fibre properties and resistance towards viral diseases [1,[4][5][6][7][8]. For instance, modification of silk fibres with nanoparticles like Ag, TiO 2 and TiO 2 @Ag are examples of in vitro studies and changing the diet of silkworms with the addition of dyes and metallic elements like TiO 2 are some examples of in vivo studies [1,2,5,6,9]. Among the stated methods, feeding method modification is promising as it limits the wastage of materials like nanopowders, dyes and other additives [1].…”

Section: Introductionmentioning

confidence: 99%

Investigating silk yield and morphological changes in silk fibres obtained from silkworms fed with Ag and/or $$\hbox {TiO}_{2}$$ nanoparticles

2019

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Natural polymers like silk can be augmented in vivo with metallic elements to improve their intrinsic properties and stability. This study demonstrates the uptake of Ag and/or TiO 2 nanoparticles as diet supplements by silkworms. Nanoparticles dose on morphological changes in silk fibroin fibres and a change in overall silk yield was investigated. Though significant fibre reinforcement with Ag and/or TiO 2 was not noticed; an increase of 6% in the silk production was observed when silkworms fed with a particular composition of Ag + TiO 2 nanoparticles (0.37 mM each) in their diet. Here, an average diameter of the degummed silk fibre was ∼10.91µM with a roughness parameter value R q being 134. This value is comparable to silk fibres obtained from silkworms fed with Ag + TiO 2 (0.22 + 0.53 mM) nanoparticles and this R q value was also low when compared to the other tested compositions with nanoparticles. Silks from the control samples (devoid of nanoparticles in their feed) had high diameter fibres and are with low R q values and silk yield. However, nanoparticle supplementation to the silkworm's diet resulted in low diameter silk fibres with varying roughnessess and with improved silk yield for the tested doses.

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Characterization of silkworm larvae growth and properties of silk fibres after direct feeding of copper or silver nanoparticles

Cited by 65 publications

References 42 publications

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

Investigating silk yield and morphological changes in silk fibres obtained from silkworms fed with Ag and/or $$\hbox {TiO}_{2}$$ nanoparticles

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