Characterization of recessive (mediator-) revertants from NIH 3T3 cells transformed with a c-H-ras oncogene

Yamada, Hisafumi; Omata-Yamada, T; Lengyel, Péter

doi:10.1016/s0021-9258(19)67893-2

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…The mechanical properties of cardiac muscle were crucial for accurately modeling its behavior under various mechanical loads and conditions in the ANSYS software 2022 R1. These properties were defined based on specific values: a Young's elastic modulus of 80 kPa [24], which represents the stiffness and resistance to deformation of the muscle; an ultimate tensile strength of 110 kPa [24,25], indicating the maximum stress the muscle can withstand before failure; and a Poisson's ratio of 0.4 [26], which shows the muscle's tendency to contract laterally when stretched longitudinally. These properties were determined based on established values from the literature, ensuring that the model accurately represents the mechanical response of cardiac muscle.…”

Section: Materials Assignmentmentioning

confidence: 99%

Advancements in Finite Element Modeling for Cardiac Device Leads and 3D Heart Models

Salih,

Hamandi,

Goswami

2024

Bioengineering

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The human heart’s remarkable vitality necessitates a deep understanding of its mechanics, particularly concerning cardiac device leads. This paper presents advancements in finite element modeling for cardiac leads and 3D heart models, leveraging computational simulations to assess lead behavior over time. Through detailed modeling and meshing techniques, we accurately captured the complex interactions between leads and heart tissue. Material properties were assigned based on ASTM (American Society for Testing and Materials) standards and in vivo exposure data, ensuring realistic simulations. Our results demonstrate close agreement between experimental and simulated data for silicone insulation in pacemaker leads, with a mean force tolerance of 19.6 N ± 3.6 N, an ultimate tensile strength (UTS) of 6.3 MPa ± 1.15 MPa, and a percentage elongation of 125% ± 18.8%, highlighting the effectiveness of simulation in predicting lead performance. Similarly, for polyurethane insulation in ICD leads, we found a mean force of 65.87 N ± 7.1 N, a UTS of 10.7 MPa ± 1.15 MPa, and a percentage elongation of 259.3% ± 21.4%. Additionally, for polyurethane insulation in CRT leads, we observed a mean force of 53.3 N ± 2.06 N, a UTS of 22.11 MPa ± 0.85 MPa, and a percentage elongation of 251.6% ± 13.2%. Correlation analysis revealed strong relationships between mechanical properties, further validating the simulation models. Classification models constructed using both experimental and simulated data exhibited high discriminative ability, underscoring the reliability of simulation in analyzing lead behavior. These findings contribute to the ongoing efforts to improve cardiac device lead design and optimize patient outcomes.

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Section: Materials Assignmentmentioning

confidence: 99%

Advancements in Finite Element Modeling for Cardiac Device Leads and 3D Heart Models

Salih,

Hamandi,

Goswami

2024

Bioengineering

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“…In the middle region, there is a constant change in the gradient of the stress-strain relationship. According to Yamada's study, for some tissues, one or both quasi-linear regions are absent; for others, the change from low modulus to high modulus occurs over a relatively small range of applied stress [31].…”

Section: Soft Structuresmentioning

confidence: 99%

Preliminary Numerical Analysis of Mechanical Wave Propagation Due to Elastograph Measuring Head Application in Non-Invasive Liver Condition Assessment

Romanowska,

Pyka,

Opieliński

et al. 2023

Applied Sciences

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The authors of this paper focused their attention on developing numerical models of mechanical wave propagation along human tissue as a result of the application of the measuring head of the FibroScan® elastograph. The FibroScan® diagnostic device is used for diagnostic testing of liver fibrosis and steatosis. This examination is carried out using an in vivo method by directly applying the surface of the ultrasonic measuring probe to the patient’s skin at the site of the liver. The authors’ idea is to use this apparatus for non-invasive testing on the liver used for transplantation. In order to do this, the measuring head cap should be modified so that its application to the liver does not result in damage as a result of mechanical wave excitation. The purpose of the manuscript was to build numerical models of the liver and the tissues surrounding the liver. Then, the corresponding numerical simulations were carried out, the results of which corresponded to the mechanical–acoustic properties of the physical models of the tissues. The obtained results were validated on a set of commercial calibrated phantoms. High agreement of the numerical models was obtained.

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Deregulation of protein synthesis as a mechanism of neoplastic transformation

Rosenwald

1996

BioEssays

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Early research on the cell cycle revealed correlations between protein accumulation and cell proliferation. In this review, I describe the data showing that abnormality of cell growth and tumor development are dependent upon oncogene-induced increases in the levels and activity of factors that determine the rate of protein synthesis. It is proposed that the establishment of a vicious circle, namely oncoproteins-->increase in translation-->oncoproteins, is a major biological mechanism that fuels neoplastic growth. The constitutively high rates of protein synthesis and accumulation of proteins, including those necessary for DNA replication and mitosis, would drive cells to excessive proliferation.

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Characterization of recessive (mediator-) revertants from NIH 3T3 cells transformed with a c-H-ras oncogene

Cited by 5 publications

References 39 publications

Advancements in Finite Element Modeling for Cardiac Device Leads and 3D Heart Models

Advancements in Finite Element Modeling for Cardiac Device Leads and 3D Heart Models

Preliminary Numerical Analysis of Mechanical Wave Propagation Due to Elastograph Measuring Head Application in Non-Invasive Liver Condition Assessment

Deregulation of protein synthesis as a mechanism of neoplastic transformation

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