Deregulation of protein synthesis as a mechanism of neoplastic transformation

Rosenwald, Igor B.

doi:10.1002/bies.950180312

Cited by 43 publications

(33 citation statements)

References 76 publications

(28 reference statements)

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“…We and others have found earlier that overexpression of eIF-4E causes increased expression of cyclin D1 in NIH T3 cells and in colonic neoplasms (40 -42). Increased expression of eukaryotic translation initiation fac- tors eIF-4E and eIF-2␣ induced by c-myc and other oncogenes has been described previously (43,44). Further studies are needed to determine the oncogenes that cause an increase in cyclin D1 expression through the translation initiation pathway in more aggressive carcinomas of the thyroid.…”

Section: Discussionmentioning

confidence: 92%

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

et al. 2000

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Cell cycle progression is facilitated by cyclindependent kinases that are activated by cyclins including cyclin D1 and inactivated by cyclindependent kinase inhibitors (CDKIs) such as p27. Our previous studies have demonstrated decreased p27 expression in both papillary and more aggressive carcinomas of the thyroid compared to thyroid adenoma and almost similar level of cyclin D1 expression between thyroid adenoma and papillary carcinoma. These results indicate that CDKIs may have an important role in the carcinogenesis of the thyroid and that they probably have a limited role in malignant progression of the thyroid cancer. The role of cyclin D1 in malignant progression of thyroid carcinoma has yet to be established. We studied the expression of cyclin D1 by immunohistochemistry in 34 cases of conventional papillary carcinoma (CPC), 10 cases of minimally invasive follicular carcinoma (MIFC), and 32 cases of more aggressive thyroid carcinoma (ATC), which included 11 tall cell variants, one columnar cell variant of papillary carcinoma, seven insular carcinomas, and 13 anaplastic carcinomas. Cyclin D1 staining was classified by staining score as 0, negative; 1؉, less than 25%; 2؉, 25 to 50%; and 3؉, more than 50% tumor cells staining positive. Kruskal-Wallis oneway ANOVA and Wilcoxon Rank Sum/MannWhitney U Test was used to assess the difference in the expression of cyclin D1 between the study groups. Twenty-eight out of the 34 CPCs were cyclin D1 positive, 24 (70%) were 1؉, 3 (9%) were 2؉, and one (3%) were 3؉ positive. Seven of 10 MIFCs were cyclin D1 positive, five (71%) were 1؉, and the remaining two (29%) were 2؉ positive. On the other hand, 28 of 32 ATCs showed cyclin D1 immunostaining. Of these, three (9%) were 1؉, five (13%) were 2؉, and 20 (63%) were 3؉ positive. This study demonstrates a significant overexpression of cyclin D1 in ATC compared CPC (P < .001) and MIFC (P < .005), suggesting that the cyclin D1 expression may play a role in tumor progression and may have prognostic significance in thyroid cancer.

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Section: Discussionmentioning

confidence: 92%

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

et al. 2000

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“…50 Whether deregulation of Pol I transcription might be an initiating step in tumorigenesis (see ref. 51 for a discussion of this hypothesis) by promoting increased cellular growth, proliferation, and transformation is thus a critical question that needs to be addressed in the near future. Wild-type (WT) or CARA cells were harvested either in log-phase (OD 600 = 1, Log) or after the post-diauxic transition (two days of culture, Post-D).…”

Section: What Are the Consequences Of Ribosome Biogenesis Deregulation?mentioning

confidence: 99%

Is Ribosome Synthesis Controlled by Pol I Transcription?

Chédin¹,

Laferté²,

Hoang³

et al. 2007

Cell Cycle

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“…Its synthesis increases in animal cells over-expressing eIF4E (Rosenwald et al, 1993). A positive feedback loop leading to unrestricted growth has been postulated linking c-Myc-induced eIF4E transcription to the enhancement of cyclin D1 synthesis (Rosenwald, 1996).…”

Section: Do Eif4e1 and Eif4e2 Have Different Functions?mentioning

confidence: 99%

The Arabidopsis thaliana cDNAs coding for eIF4E and eIF(iso)4E are not functionally equivalent for yeast complementation and are differentially expressed during plant development

et al. 1998

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SummaryTwo cDNAs (At.EIF4E1 and At.EIF4E2) encoding, respectively, the eukaryotic initiation factors eIF4E and eIF(iso)4E of Arabidopsis thaliana were isolated by complementation of a Saccharomyces cerevisiae conditional mutant. The deduced amino acid sequences of the proteins are homologous to those from monocotyledonous plants, yeast and mammals. The corresponding genes were identified in YAC clones mapping to chromosome IV (At.EIF4E1) and to chromosome V (At.EIF4E2). The yeast strain complemented by At.EIF4E2 grew poorly compared with an isogenic strain expressing At.EIF4E1. Northern and in situ hybridization analysis show that both Arabidopsis At.EIF4E1 and At.EIF4E2 mRNAs are differentially accumulated in plant tissues. The At.EIF4E1 mRNA is expressed in all tissues except in the cells of the specialization zone of the roots; the At.EIF4E2 mRNA is particularly abundant in floral organs and in young developing tissues. This work further demonstrates an association between a high level of EIF4E mRNAs and cell proliferation and suggests that the plant eIF4E isoforms may have distinct functions in cell development and metabolism.

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Deregulation of protein synthesis as a mechanism of neoplastic transformation

Cited by 43 publications

References 76 publications

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

Is Ribosome Synthesis Controlled by Pol I Transcription?

The Arabidopsis thaliana cDNAs coding for eIF4E and eIF(iso)4E are not functionally equivalent for yeast complementation and are differentially expressed during plant development

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