Characterization of putative growth hormone receptors in human choroid plexus

Lai, Zhennan; Emtner, Morgan; Roos, Paul; Nyberg, Fred

doi:10.1016/0006-8993(91)91485-j

Cited by 141 publications

(73 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our study identified no correlation between QOL and direct measures of body composition, suggesting that improvement in body composition alone is not responsible for GH effects on QOL. Specific receptors for GH have been identified in several areas of the human brain (35) with the highest concentration being found in the choroid plexus, followed by the pituitary, hippocampus, putamen, hypothalamus and thalamus (35,36). These represent areas of potential access into the central nervous system, and key limbic system structures known to be pivotal for the physiology of vegetative functions and in the control of behaviour, emotion and motivation, suggesting a possible central role for GH effects on QOL.…”

Section: Discussionmentioning

confidence: 99%

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

Mukherjee

Adams²,

Smethurst³

et al. 2005

eur j endocrinol

View full text Add to dashboard Cite

Lean body mass (LBM) and total body water (TBW) are reduced in GH-deficient (GHD) adults and alter with GH replacement. Whether these parameters are interdependent and whether alterations in their homeostasis contribute to the perceived quality of life (QOL) deficit in GHD remains unclear. In this study, IGF-I, body composition by whole-body dual-energy X-ray absorptiometry, TBW by deuterium dilution (D 2 O) and two validated QOL instruments -psychological general well-being schedule (PGWB, generic, 6 domains; lower score worse QOL) and assessment of GH deficiency in adults (AGHDA, disease orientated; higher score worse QOL) were studied at baseline and after 3 and 6 months of GH replacement in thirty GHD adults. Patients with diabetes insipidus, and cardiac and renal failure were excluded. Median age-adjusted IGF-I standard deviation score increased from 2 3.40 (26.40 to 2 1.60) to 2 0.2 (2 1.88 to 0.78) (P , 0.0001) at a median daily GH dose of 0.4 mg. During treatment, LBM increased from 47.4^10.7 kg at baseline to 49.5^10.8 kg at 6 months (P ¼ 0.0008), and fat mass decreased from 28.0^12.1 kg at baseline to 27.2^12.6 kg at 6 months (P ¼ 0.0004). A non-significant trend towards an increase in TBW was observed (mean 1.7 kg, P ¼ 0.08). The PGWB score increased from 62.9^20.6 to 73.7^21.7 (P ¼ 0.0006). The AGHDA score decreased from 13.7^7.3 to 8.75^7.75 (P ¼ 0.0002). At each time point, a linear correlation between LBM and TBW was demonstrated, defined by TBW ¼ (0.972 £ LBM)-10.6. However, only a weakly positive correlation existed between the percentage changes in these variables (R ¼ 0.40, P ¼ 0.04). No correlations were demonstrated between QOL measures and body composition. The change in LBM with physiological GH replacement correlates weakly with change in TBW, therefore factors other than TBW may also contribute to the LBM changes. Improved QOL with GH replacement is not explained by favourable changes in body composition.European Journal of Endocrinology 153 661-668

show abstract

Section: Discussionmentioning

confidence: 99%

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

Mukherjee

Adams²,

Smethurst³

et al. 2005

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Another study revealed the GH binding capacity of human brain tissue [20]. In this initial study, adult male and female brain specimens were obtained hours post mortem at autopsy and assayed for radio-labeled human GH (hGH) binding capacity [20].…”

Section: Expression Of Ghr In the Brainmentioning

confidence: 99%

GH in the Central Nervous System: Lessons from the Growth Hormone Receptor Knockout Mouse

Gosney¹,

Jara²,

Basu

et al. 2012

TOEJ

View full text Add to dashboard Cite

Various central nervous system (CNS) tissues express both growth hormone (GH) and its receptor (GHR), including those involved in memory and cognition. Studies show the presence of GHR in the pituitary, choroid plexus, hypothalamus, hippocampus, pituitary and the spinal cord during development and, to a lesser extent, in adults. This expression implies a role of GH signaling in growth, development and functionality of the CNS. While data on the function of GH in the CNS is sparse, several studies have been conducted using the GHR knockout (-/-) mouse in order to better understand this role. Abnormal growth hormone signaling in humans is the cause of various diseases that include Laron syndrome, GH deficiency and acromegaly. This article will review the research conducted using the GHR-/-mouse on the role of GH signaling in the CNS. Where possible, we will attempt to contextualize the animal data with respect to human disease.

show abstract

“…Although the BBB is generally considered to be impermeable to GH, peripheral GH may access the CNS by non-specific mechanisms during development and stress, when vascular permeability is increased. The presence of abundant GH-binding activity in the human choroid plexus (Lai et al 1991) also suggests that specific, receptor-mediated GH uptake may occur at the circumventricular organs (Coculescu 1999). CNS GH immunoreactivity may also reflect local synthesis, since GH mRNA has been detected in the rodent and avian brain (Harvey & Hull 2003).…”

Section: Therapeutic Mechanisms: Neural Effectsmentioning

confidence: 99%

“…Regardless of the source of the GH, direct neural actions of GH are suggested by the presence of GHbinding sites in the human hippocampus, putamen, thalamus, hypothalamus and pituitary gland (Lai et al 1991) and by GH receptor (GHR) immunoreactivity in the fetal brain (Hill et al 1992). The hippocampal GHbinding activity is of particular interest, since this region plays a significant role in posulated GH-dependent processes (memory, motivation, and attention) (Nyberg 2000).…”

Section: Therapeutic Mechanisms: Neural Effectsmentioning

confidence: 99%

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

Hull

Harvey²

2003

Journal of Endocrinology

View full text Add to dashboard Cite

The actions of growth hormone (GH) are not restricted to growth: GH modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary physiology. The importance of GH in most physiological systems suggests that GH deficiency at any age would be associated with significant morbidity. However, prior to the advent of recombinant GH, cadaverderived GH was only used therapeutically to correct the height deficit, and thereby hypothetically improve quality of life (QoL), in GH-deficient children. Physicians now have access to unlimited, albeit expensive, supplies of recombinant GH, and are considering the advisability of GH replacement or supplementation in other patient populations. This paper analyses studies investigating the relationship between GH and QoL in GH-deficient children or adults, in GH-replete short children suffering from idiopathic short stature, Turner syndrome, or intrauterine growth retardation and in GH-deficient or replete elderly adults. Possible mechanisms by which GH might improve QoL at neural and somatic sites are also proposed.

show abstract

Characterization of putative growth hormone receptors in human choroid plexus

Cited by 141 publications

References 18 publications

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

Interdependence of lean body mass and total body water, but not quality of life measures, during low dose GH replacement in GH-deficient adults

GH in the Central Nervous System: Lessons from the Growth Hormone Receptor Knockout Mouse

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

Contact Info

Product

Resources

About