Characterization of Phenolic Constituents and Pharmacological Activity of Achillea vermicularis

Abstract

Taskin et al.: Biological activity of Achillea vermicularis The aim of the present study was to compare for the first time, the antiinflammatory, antioxidant and antiurease activities of 15 different extracts of Achillea vermicularis, which were obtained from three extraction methods using five different solvents. Phenolic contents in chloroform extract showed strong antiinflammatory and antioxidant activity and were analysed by high-performance liquid chromatography with diode-array detection and confirmed by liquid chromatography quadrupole time-of-flight mass spectrometry. The active phenolic compounds in chloroform extracts were identified as chlorogenic acid, caffeic acid, rutin, dicaffeoylquinic acid, naringenin, quercetagetin 3,6-dimethyl ether, and 8-hydroxysalvigenin. All these compounds except caffeic acid were detected for the first time in Achillea vermicularis. These results indicated that chloroform extract of the plant possessed a high potential to be used as a natural source in food and pharmaceutical industry.

Polyphenol content and bioactivity of Achillea moschata from the Italian and Swiss Alps

“…Although there may be significant inter-and intraspecific differences in the polyphenol content of the Achillea species due to factors such as their origin, the plant growth stage, the analyzed plant part, the extraction solvent and the extraction method, previous data suggested that phenolic acids and flavonoids may be the major contributors for the radical scavenging activity of the Achillea extracts [17][18][19][22][23][24].…”

Phytochemistry and Evidence-Based Traditional Uses of the Genus Achillea L.: An Update (2011–2021)

“…Two flavones bearing a methoxy group attached to C-7 or C-3 were reported once, namely 7-O-methyl apigenin (3) (from A. ligustica) [35] and chrysoeriol (20) (from A. millefolium) [40], respectively. Moreover, other methylated flavonoids, such as cirsiliol (22) and cirsimaritin (4), were reported for A. fragrantissima [31,33]; salvigenin (5) for A. millefolium [41] and A. wilhelmsi [50]; and 8-hydroxysalvigenin (6) was identified for A. lycaonica A. monocephala and A. vermicularis [36,42,49]. Moreover, eupatorin (21) was reported for A. alpina and A. tenuifolia [17,48], while eupatilin 7-methyl ether (5-demethylsinensetin) (23) for A. wilhelmsii [25].…”

“…Likewise, some examples with low reappearance in Achillea species were quercetagetin 3,3 -dimethyl ether (48) isolated from A. millefolium [39], penduletin (40) isolated from A. alpina [18], chrysosplenol D (51) reported from A. fragrantissima [31], centaureidin (49) reported from A. millefolium [39] and A. coarctata [7]. Apart from the above-mentioned menthoxy-or polymethoxy-flavonols (3-hydroxyflavones), there are also others such as jaceidin (52) reported from A. alpina [18], A. biebersteinii [26] and A. millefolium [27,39]; santin (41) reported from A. biebersteinii [24] or A. ligustica [35]; casticin (53) isolated from A. coarctata [7] and A. millefolium [39]; and axillarin (47) reported from A. biebersteinii [24], A. grandifolia [45] and A. vermicularis [49]. Interestingly, Huo et al [39] isolated for the first time a rare biflavonoid, namely 8,8 -bi-3-O-methylquercetin (70) from A. millefolium.…”

“…subsp. kotschyi, A. lycaonica, A. monocephala and A. vermicularis [49] and dihydroquercetin (64) from A. millefolium [41]. 29) Hyperoside ( 59) Kaempferol ( 37) Luteolin ( 19) Naringenin ( 66) Quercetin ( 44) Rutin ( 58)…”

Complexes of Metals With Hydrazone Hydrazide Salicylic Acid

“…The absorbance of the mixture was regarded relative to the reference at 635 nm. The anti-urease activity of the extracts was assessed by the indophenol method [12]. The results of this CHEMICAL PROBLEMS 2021 no.…”