Characterization of pasteurized milk in the near infrared range for construction of tissue-mimicking optical phantoms

Bachir, Wesam; khir, Rewa

doi:10.1016/j.omx.2022.100154

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…In the following, we scrutinize the applicability of previous findings to a set of well-characterized physiological substances: bovine SM (Millipore 70166) and 20% IL (Sigma-Aldrich I141), commonly used as compounds in tissue-mimicking samples because of their optical properties ( 52 , 53 , 54 , 55 , 56 , 57 ).…”

Section: Resultsmentioning

confidence: 99%

Estimation of the mass density of biological matter from refractive index measurements

Möckel,

Beck,

Kaliman

et al. 2024

Biophysical Reports

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Section: Resultsmentioning

confidence: 99%

Estimation of the mass density of biological matter from refractive index measurements

Möckel,

Beck,

Kaliman

et al. 2024

Biophysical Reports

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“…Vegetable milk was used as a scattering agent because it is inexpensive, simple to prepare, and has good optical properties that have been reported for the manufacture of phantoms [26]. In contrast with others scattering agents, such as white nanoparticles, like titanium dioxide or aluminum oxide, as well as polymer or lipid microspheres, they require a calibration process during production, with Intralipid being the most reported [27].…”

Section: Resultsmentioning

confidence: 99%

Agarose Gel Characterization for the Fabrication of Brain Tissue Phantoms for Infrared Multispectral Vision Systems

Albor-Ramírez,

Reyes-Alberto,

Vidal-Flores

et al. 2023

Gels

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Synthetic phantoms that recreate the characteristics of biological tissues are valuable tools for systematically studying and comprehending physiologies, pathologies, and biological processes related to tissues. The reproduction of mechanical and optical properties allows for the development and evaluation of novel systems and applications in areas such as imaging, optics, ultrasound, or dosimetry, among others. This paper proposes a methodology for manufacturing agarose-based phantoms that mimics the optical properties of healthy brain tissue within the wavelength infrared range of 800 to 820 nm. The fabrication of such phantoms enables the possibility of testing and experimentation in controlled and safe environments toward the design of new near-infrared multispectral imaging systems in neurosurgery. The results of an experimental optical characterization study indicate the validity and reliability of the proposed method for fabricating brain tissue phantoms in a cost-effective and straightforward fashion.

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“… 5 Here, we present a short overview of some of the different tissue phantoms successfully used in biomedical optics in recent years. The first group consists of liquid phantoms, 6 , 7 which are usually based around a liquid scattering base, such as Intralipid or milk, 8 with the addition of a pigment, such as India ink. They are affordable and straightforward to prepare but are challenging to use in complex geometries while also exhibiting a short shelf-life and variations between different batches of input components.…”

Section: Introductionmentioning

confidence: 99%

“…These characteristics usually limit their use because they can give rise to an erroneous evaluation of the scattering coefficient. 8 …”

Section: Introductionmentioning

confidence: 99%

Effects of phantom microstructure on their optical properties

Stergar,

Hren,

Milanič

2024

J. Biomed. Opt.

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. Significance Developing stable, robust, and affordable tissue-mimicking phantoms is a prerequisite for any new clinical application within biomedical optics. To this end, a thorough understanding of the phantom structure and optical properties is paramount. Aim We characterized the structural and optical properties of PlatSil SiliGlass phantoms using experimental and numerical approaches to examine the effects of phantom microstructure on their overall optical properties. Approach We employed scanning electron microscope (SEM), hyperspectral imaging (HSI), and spectroscopy in combination with Mie theory modeling and inverse Monte Carlo to investigate the relationship between phantom constituent and overall phantom optical properties. Results SEM revealed that microspheres had a broad range of sizes with average and were also aggregated, which may affect overall optical properties and warrants careful preparation to minimize these effects. Spectroscopy was used to measure pigment and SiliGlass absorption coefficient in the VIS-NIR range. Size distribution was used to calculate scattering coefficients and observe the impact of phantom microstructure on scattering properties. The results were surmised in an inverse problem solution that enabled absolute determination of component volume fractions that agree with values obtained during preparation and explained experimentally observed spectral features. HSI microscopy revealed pronounced single-scattering effects that agree with single-scattering events. Conclusions We show that knowledge of phantom microstructure enables absolute measurements of phantom constitution without prior calibration. Further, we show a connection across different length scales where knowledge of precise phantom component constitution can help understand macroscopically observable optical properties.

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Characterization of pasteurized milk in the near infrared range for construction of tissue-mimicking optical phantoms

Cited by 5 publications

References 15 publications

Estimation of the mass density of biological matter from refractive index measurements

Estimation of the mass density of biological matter from refractive index measurements

Agarose Gel Characterization for the Fabrication of Brain Tissue Phantoms for Infrared Multispectral Vision Systems

Effects of phantom microstructure on their optical properties

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