Characterization of particle shape, zeta potential, loading efficiency and outdoor stability for chitosan-ricinoleic acid loaded with rotenone

Abstract

Carboxymethyl chitosan grafted with ricinoleic acid (CMC-g-RA), an amphiphilic drug carrier, was synthetized, loaded with rotenone (Rot), and characterized for particles shape, zeta potential, loading efficiency and outdoor stability. Results show that as the ratio of carrier to drug increased, the formulation exhibited monodisperse nanoparticles negative surface charge. The loading efficiency of the formulation was up to 68%. The outdoor test also indicated that the formulation with the higher loading efficiency prevented Rot degradation in natural environments.

N‐deoxycholic acid‐O‐glycol chitosan as a potential carrier agent for botanical pesticide rotenone

“…Meanwhile, there was no significant difference observed in the FTIR of rotenone‐loaded DAGC at different weight ratios. New absorption bands was observed at 1715, 1694, and 1698 cm −1 in the FTIR spectra of rotenone‐loaded DAGC, which might be due to C=O stretched and C=C alkene stretched rotenone . In addition, the intensity of the peak attributed to aliphatic alkyl were also increased, and the absorption band corresponding to amino group was shifted.…”

“…Meanwhile, the absorption band related to C–O stretched became sharper and shifted from 1030 cm −1 to 1041 and 1040 cm −1 . The change in the FTIR spectra might be due to the interaction of rotenone with the functional groups of DAGC and implied that the rotenone was successfully loaded into the DAGC micelle …”

“…The efficiency of DAGC to load rotenone was comparable to other polymers. For instance, it has been reported that chitosan–ricinoleic acid encapsulated rotenone up to 68% . Meanwhile, chitosan–poly(lactic acid) had an encapsulation efficiency of 57.1–71.3% for rotenone …”

Synthesis of rotenone loaded zein nano-formulation for plant protection against pathogenic microbes

“…In the FTIR spectrum, the peaks around 2938, 1674, 1605, 1515, 1456, 1357 and 1091 cm À1 are relevant to C-H, C]O, C-O and C]C stretching frequencies of the cyclic alkene which is present in pure rotenone structures. 9,25,26 The peaks around 2938 cm À1 contributed to the C-H bending of aromatic alkyl which may be attributed to the characteristic peak of pure rotenone which were found around 2968 cm À1 in case of RNZSC. 27,28 Based on spectral changes in alkyl groups and increased in the intensity of characteristic bands at 2968, 1663, 1535, 1458, 1359 and 1093 cm À1 frequencies, it can be concluded that the rotenone was successfully loaded on zein nanoparticles (RNZSC).…”

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

“…236 More examples on this nanoparticle are available in Table 1. [237][238][239][240][241] Biopolymer-based Hydrogels (BBH) Hydrogels are cross-linked polymeric networks with hydrophilic functionalities that supply spaces for homing aqueous biological fluids ( Figure 17) and have is known as a promising bio-compatible material in numerous therapeutic applications. 12,242 This formula is characterized by adorable biocompatibility, high porosity, hydrophilicity that results in controlled drug release.…”