Characterization of PAGAT dose response upon different irradiation conditions

Magugliani, Gabriele; Liosi, Giulia Maria; Tagliabue, D.; Mossini, Eros; Negrin, M.; Mariani, Mario

doi:10.1080/10420150.2018.1528604

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Various methods were adopted to eliminate oxygen such as preparation of gel solution in a inert gas (such as nitrogen or argon gas) atmosphere [ 13 ] or by using antioxidants[ 14 ]. More details about radiation chemistry in polyacrylamide gels can be found in literature [ 55 , 58 , 59 , 60 , 61 ].…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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“…Highly tissue-equivalent hydrogels are commonly used for dosimetry in brachytherapy, [ 8 ] three-dimensional conformal radiotherapy, [ 9 ] intensity-modulated radiotherapy [ 10 ] and stereotactic radiotherapy. [ 11 ] These hydrogel dosimeters include Fricke, BANANA, BANG, and radiofluorogenic hydrogel dosimeters.…”

Section: Introductionmentioning

confidence: 99%

Enhanced X-ray Dose Response of Radio-fluorescent Hydrogels Enabled by Persulfate Salts

Qin

Han

2023

J Fluoresc

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Coumarin 3-carboxylic acid (CCA)-loaded radio-fluorescent hydrogels have attracted interest for ionizing radiation dosimeters, but their sensitivity needs to be improved. In this study, we added ammonium persulfate (APS) to a polyacrylamide (PAAm)-CCA hydrogel. The introduction of APS improved the hydrogel dose sensitivity to 336.02 Gy − 1 , which is 1.8 times that of the counterpart without APS. Our hydrogel can measure the X-ray dose in a range of 0 − 15 Gy with a lower limit of detection (LOD) of 0.1 Gy. Additionally, the hydrogel can sense X-ray doses within a wide range of the dose rate and temperature, and the dose‒response can be well retained 7 days postirradiation. Therefore, we think this study provides a simple and robust method to improve the sensitivity of CCA hydrogel dosimeters, presenting great potential in clinical radiotherapy.

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