Enhanced X-ray Dose Response of Radio-fluorescent Hydrogels Enabled by Persulfate Salts

Abstract

Coumarin 3-carboxylic acid (CCA)-loaded radio-fluorescent hydrogels have attracted interest for ionizing radiation dosimeters, but their sensitivity needs to be improved. In this study, we added ammonium persulfate (APS) to a polyacrylamide (PAAm)-CCA hydrogel. The introduction of APS improved the hydrogel dose sensitivity to 336.02 Gy − 1 , which is 1.8 times that of the counterpart without APS. Our hydrogel can measure the X-ray dose in a range of 0 − 15 Gy with a lower limit of detection (LOD) of 0.1 Gy. Additionally, the hydrogel can sense X-ray doses within a wide range of the dose rate and temperature, and the dose‒response can be well retained 7 days postirradiation. Therefore, we think this study provides a simple and robust method to improve the sensitivity of CCA hydrogel dosimeters, presenting great potential in clinical radiotherapy.

A rhodamine coumarin-derived fluorescence probe that selectively detects Fe3+ and measures radiation doses

“…Fluorescence sensors are also used to measure ionizing radiation doses. 17–21 Usually, the underlying mechanism of these sensors involves a weak fluorescence moiety combined with hydroxyl radicals due to water radiolysis, transitioning to a strong fluorescence moiety. Accordingly, the dosing can be measured by fluorescence methodology.…”