Characterization of non‐producer human cells induced by kirsten sarcoma virus

Rhim, Johng S.; Cho, H. Y.; Vernon, Mina Lee; Arnstein, Paul; Huebner, Robert J.; Gilden, Raymond V.; Nelson‐Rees, Walter A.

doi:10.1002/ijc.2910160516

Cited by 32 publications

(15 citation statements)

References 38 publications

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“…HOS, (originally M.T., then TE-85), was one of the Wrst human osteosarcoma cell lines to be comprehensively characterised in vitro (McAllister et al 1971;Rhim et al 1975) and was derived from the distal femur of a 13-year-old Caucasian girl. Amongst the human osteosarcoma cell lines trialed in vivo, it has been studied extensively, particularly for research into pathological viruses such as Human T-cell leukemia virus (HTLV) (Clapham et al 1983), human cytomegalovirus (HCMV) (Ho et al 1990), and the human immunodeWciency virus type 1 (HIV-1) (Ho et al 1990).…”

Section: Hos and Krib Cell Linesmentioning

confidence: 99%

“…Tumorigenic potential, however, has been possible with transformation of the HOS cell line, which in turn have facilitated many in vivo models being established using various derivatives of the cell line. Successful transformation of HOS has been achieved using viral agents Kirsten murine sarcoma virus (Ki-MSV) (Rhim et al 1975) and Moloney sarcoma virus (M-MSV RD-114) (Friedlaender and Mitchell 1976) …”

Section: Hos and Krib Cell Linesmentioning

confidence: 99%

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Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing

Dass

Choong

2006

J Cancer Res Clin Oncol

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Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progression of this debilitating and fatal disease. Such a model is long overdue given the devastating demographics (second highest cause of cancer-related death in the paediatric age group) of the ailment and the lack of solid options for control, if not cure, for the disease, as it also is the most common primary tumour of bone. Only then can more robust R & D be undertaken in the search for efficacious anti-osteosarcoma agents. This review tackles this conundrum and lists the variety of models (that use human osteosarcoma cells) available and the types of studies performed with these.

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Section: Hos and Krib Cell Linesmentioning

confidence: 99%

Section: Hos and Krib Cell Linesmentioning

confidence: 99%

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing

Dass

Choong

2006

J Cancer Res Clin Oncol

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“…Cell lines KB13, 30, 57 and 106 are cybrids of the nuclei from 143B206 [22] and the cytoplasms from patients with mitochondrial disease [23]. Cell line 143B12-3A2 is a rho o derivative of 143B tk - [22] derived from a Kirsten murine sacroma virus-transformed human osteosarcoma cell line HOS [24], which was isolated from a 13-year old Caucasian female [25][26]. NA10495A, NA10496A, NA11325, NA11324, NA10846 and NA10847 are DNA samples from National Institute of General Medical Sciences (NIGMS).…”

Section: Cell Tissue and Dna Samplesmentioning

confidence: 99%

Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome

et al. 1999

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Novel pseudogenes homologous to the mitochondrial (mt) 16S rRNA gene were detected via different approaches. Eight pseudogenes were sequenced. Copy number polymorphism of the mtDNA pseudogenes was observed among randomly chosen individuals, and even among siblings. A mtDNA pseudogene in the Y-chromosome was observed in a YAC clone carrying only repetitive sequence tag site (STS). PCR screening of human yeast artificial chromosome (YAC) libraries showed that there were at least 5.7 10 5 bp of the mtDNA pseudo-genes in each haploid nuclear genome. Possible involvement of the mtDNA pseudogenes in the variable part of the human nuclear genome is discussed.

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“…Six cocultivation experiments (CC-I-CC-VI) were performed with SU-DHL-1 cells and KHOS, a nonproducer human osteogenic sarcoma cell line infected with the Kirsten murine sarcoma virus (19). The cells were grown in flask cultures at SU-DHL-1/KHOS cell ratios ranging from 5:1 to 50:1.…”

mentioning

confidence: 99%

Isolation of a type C RNA virus from an established human histiocytic lymphoma cell line.

Kaplan¹,

Goodenow²,

Epstein³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

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A type C RNA virus has been detected in the culture fluids of the SU-DHL-1 human histiocytic lymphoma cell line previously established in this laboratory. In electron micrographs, the virus closely resembled other typical mammalian type C RNA tumor viruses in size and morphology. Viral RNA-dependent DNA polymerase activity has been demonstrated in particles (densities of 1.15 and 1.22 g/ml) in the microsomal cytoplasmic fraction and in pellets of culture fluids. The enzyme is partially inhibited by antibodies to the RNAdependent DNA polyerases of simian sarcoma virus and RD-i 14 virus but not by antibody to the polymerase of murine leukemia virus, suggesting some degree of relatedness to type C viruses of subhuman primate origin. Typical syncytial microplaques were induced when SU-DHL-1 cells were cocultivated with rat XC cells. Although no focus formation was noted in similarly cocultivated mouse UC1-B cell cultures, the numbers of foci induced in rat embryo fibroblasts by murine sarcoma virus were significantly increased by coinfection with the virus from SU-DHL-1 cell culture fluids. No other evidence of infectivity, inducibility, or capacity for helper rescue of defective murine sarcoma virus genomes has been detected to date in cocultivation studies with a spectrum of fibroblastic and other nonlymphoid indicator cell lines of human and other species of origin. Type C RNA viruses have been identified as causative agents of leukemias, lymphomas, and sarcomas in avian, murine, feline, cavian, bovine, and subhuman primate species (cf. ref.

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Characterization of non‐producer human cells induced by kirsten sarcoma virus

Cited by 32 publications

References 38 publications

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing

Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome

Isolation of a type C RNA virus from an established human histiocytic lymphoma cell line.

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