Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging

Shan, Liang; Chopra, Arvind; Leung, Kam; Eckelman, William C.; Menkens, Anne E.

doi:10.1007/s11051-012-1122-z

Cited by 15 publications

(16 citation statements)

References 54 publications

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“…Furthermore, many hurdles involved with in vivo pharmacokinetics can reduce the delivery of contrast agents to tissues that harbor a molecular biomarker. Nanocarriers may potentially be used to address these two potential pitfalls, including linear polymers, branched polymers, proteins, micelles, liposomes, and hydrogels . A payload of tens‐to‐thousands of MRI contrast agent molecules may be packaged in these nanocarriers, which can greatly amplify detection sensitivity.…”

Section: Future Directionsmentioning

confidence: 99%

A review of responsive MRI contrast agents: 2005–2014

Hingorani

Bernstein

Pagel

2014

Contrast Media & Molecular

174

184

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This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency, or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including examples that employ nuclei other than 1H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents.

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Section: Future Directionsmentioning

confidence: 99%

A review of responsive MRI contrast agents: 2005–2014

Hingorani

Bernstein

Pagel

2014

Contrast Media & Molecular

174

184

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“…Theoretically, nuclei with an odd number of protons and neutrons have non‐zero magnetic moment‐associated nuclear spin, which allows them to generate MR signal. Such nuclei include 1 H, 2 H, 3 He, 11 B, 13 C, 19 F, 23 Na, 31 P, and 129 Xe [17,18] . 19 F in particular has shown promise for MR imaging.…”

Section: Introductionmentioning

confidence: 99%

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Cui

et al. 2022

ChemMedChem

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Fluorine magnetic resonance imaging (19F MRI) is a promising imaging technique for cancer diagnosis because of its excellent soft tissue resolution and deep tissue penetration, as well as the inherent high natural abundance, almost no endogenous interference, quantitative analysis, and wide chemical shift range of the 19F nucleus. In recent years, scientists have synthesized various 19F MRI contrast agents. By further integrating a wide variety of nanomaterials and cutting‐edge construction strategies, magnetically equivalent 19F atoms are super‐loaded and maintain satisfactory relaxation efficiency to obtain high‐intensity 19F MRI signals. In this review, the nuclear magnetic resonance principle underlying 19F MRI is first described. Then, the construction and performance of various fluorinated contrast agents are summarized. Finally, challenges and future prospects regarding the clinical translation of 19F MRI nanoprobes are considered. This review will provide strategic guidance and panoramic expectations for designing new cancer theranostic regimens and realizing their clinical translation.

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“…For reviews focused on nanoparticles, we suggest a few other reviews. [26][27][28][29][30][31] This review is divided into four sections: (1) optimization of Gd III -based agents; (2) Eu II -containing cryptates as T 1 -shortening agents; (3) 19 F-MRI agents; and (4) chemical exchange saturation transfer agents.…”

Section: Introductionmentioning

confidence: 99%

Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths

Kuda-Wedagedara

Allen

2014

Analyst

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Contrast agents are diagnostic tools that often complement magnetic resonance imaging. At ultra-high field strengths (≥7 T), magnetic resonance imaging is capable of generating desirable high signal-to-noise ratios, but clinically available contrast agents are less effective at ultra-high field strengths relative to lower fields. This gap in effectiveness demands the development of contrast agents for ultra-high field strengths. In this minireview, we summarize contrast agents reported during the last three years that focused on ultra-high field strengths.

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Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging

Cited by 15 publications

References 54 publications

A review of responsive MRI contrast agents: 2005–2014

A review of responsive MRI contrast agents: 2005–2014

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths

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Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging

Cited by 15 publications

References 54 publications

A review of responsive MRI contrast agents: 2005–2014

A review of responsive MRI contrast agents: 2005–2014

19F MRI Nanotheranostics for Cancer Management: Progress and Prospects

Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths

Contact Info

Product

Resources

About

¹⁹F MRI Nanotheranostics for Cancer Management: Progress and Prospects