Abstract:Dissolution rate impacts the absorption rate of poorly
soluble
inhaled drugs. In vitro dissolution tests that can capture the impact
of changes in critical quality attributes of the drug product on in
vivo dissolution are important for the development of products containing
poorly soluble drugs, as well as modified release formulations. In
this study, an extended mathematical model allowing for dissolution
of polydisperse powders and subsequent diffusion of dissolved drug
across a membrane is described. In vit… Show more
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