Characterization of melamine-associated urinary stones in children with consumption of melamine-contaminated infant formula

Chang, Hong; Shi, Xiaofeng; Shen, Wei; Wang, Wei; Yue, Zhongjin

doi:10.1016/j.cca.2012.02.025

Cited by 24 publications

(9 citation statements)

References 28 publications

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“…Higher dose of melamine may result in urinary tract obstruction as reported in the clinical findings in the period of the milk scandal . Infant urinary tract obstruction can lead to end‐stage renal disease in children.…”

Section: Discussionmentioning

confidence: 92%

“…The renal developmental stage of rats at birth to postnatal week 2 is similar to that of the human second and third tri- Higher dose of melamine may result in urinary tract obstruction as reported in the clinical findings in the period of the milk scandal. [52][53][54] Infant urinary tract obstruction can lead to end-stage renal disease in children. The outcome depends on the time of obstruction, whether prenatal or postnatal.…”

Section: Neonatal Nephrotoxicitymentioning

confidence: 99%

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Effects of low‐dose melamine exposure during pregnancy on maternal and fetal kidneys in rats

Chu

Fung

Wang

2017

Environmental Toxicology

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Despite the previous reports on melamine contamination in high concentrations some years ago, there were not many studies on low-level exposure in daily life, particularly in pregnancy. We investigated the effect of low-dose melamine on the kidneys of the pregnant rats and their developing embryos/fetuses during various gestational stages namely implantation, gastrulation, organogenesis, maturation and whole pregnancy. Our results showed that the repeated low level of melamine (12.5, 25, and 50 mg/kg bw/d) during pregnancy did not cause obstruction of renal tubules although more precipitating crystals were found in the early gestational periods. Simple hyperplasia in the maternal tubules and pelvic epithelium were more prominent after exposed to melamine during the whole gestational period. Neonatal kidneys significantly suffered more from congestion in glomeruli and interstitium, dilated tubules and interstitial edema after melamine administration to the mother in the late and the whole gestational periods. A trend of advance of glomerular development in fetuses was also observed. We conclude that in utero exposure of low-level melamine could post a risk on the kidneys of the pregnant mother as well as the developing fetuses, which may further increase the possibility of other health problems later in life.

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Section: Discussionmentioning

confidence: 92%

Section: Neonatal Nephrotoxicitymentioning

confidence: 99%

Effects of low‐dose melamine exposure during pregnancy on maternal and fetal kidneys in rats

Chu

Fung

Wang

2017

Environmental Toxicology

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“…The reasons were initially unclear, as melamine itself has very low acute toxicity. Biopsies from victims showed melamine urate precipitates in renal tubules (65,66), a pathology known to be induced by coadministration of melamine and its structural analog cyanuric acid, which together form insoluble crystals (refs. 67, 68, and Figure 3).…”

Section: R E V I E W S E R I E S : G U T M I C R O B I O M Ementioning

confidence: 99%

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

Carmody¹,

Turnbaugh²

2014

J. Clin. Invest.

212

145

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“…Probably the largest infant food safety problem ever occurred in 2008 in China: infant formula was produced from milk to which melamine had been added to sham a higher protein content, which caused urolithiasis and related damage in a large number of infants [23,24,25,26,27]. It is estimated that more than 300,000 infants were exposed to such adulterated formula, with tens of thousands of hospitalizations and 6 reported deaths [27,28].…”

Section: Adulterationmentioning

confidence: 99%

Quality and Safety Aspects of Infant Nutrition

Koletzko¹,

Shamir

Ashwell

2012

Ann Nutr Metab

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Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition. Unbalanced diets and harmful food components induce particularly high risks for untoward effects in infants because of their rapid growth, high nutrient needs, and their typical dependence on only one or few foods during the first months of life. The concepts, standards and practices that relate to infant food quality and safety were discussed at a scientific workshop organized by the Child Health Foundation and the Early Nutrition Academy jointly with the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, and a summary is provided here. The participants reviewed past and current issues on quality and safety, the role of different stakeholders, and recommendations to avert future issues. It was concluded that a high level of quality and safety is currently achieved, but this is no reason for complacency. The food industry carries the primary responsibility for the safety and suitability of their products, including the quality of composition, raw materials and production processes. Introduction of new or modified products should be preceded by a thorough science based review of suitability and safety by an independent authority. Food safety events should be managed on an international basis. Global collaboration of food producers, food-safety authorities, paediatricians and scientists is needed to efficiently exchange information and to best protect public health.

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Characterization of melamine-associated urinary stones in children with consumption of melamine-contaminated infant formula

Cited by 24 publications

References 28 publications

Effects of low‐dose melamine exposure during pregnancy on maternal and fetal kidneys in rats

Effects of low‐dose melamine exposure during pregnancy on maternal and fetal kidneys in rats

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

Quality and Safety Aspects of Infant Nutrition

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