Characterization of Limonoids in Citrus Essential Oils by Means of Supercritical Fluid Chromatography Tandem Mass Spectrometry

Zoccali, Mariosimone; Arigò, Adriana; Russo, Marina; Salafia, Fabio; Dugo, Paola; Mondello, Luigi

doi:10.1007/s12161-018-1303-1

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…In lemon and mandarin essential oil, γ-terpinene and β-pinene account for 8–20% and 0.3–11% of the total compounds, respectively [ 51 ]. Among the cold-pressed citrus essential oil from lemon, bergamot, sweet orange, clementine, bitter orange, blood orange, mandarin (green, yellow, red), and pink grapefruit, the highest amount of limonin (21.2 mg/L) was recorded from bergamot essential oil, while essential oils from clementine and blood orange presented the lowest (0.5–0.9 mg/L) limonin content [ 58 ]. In this study, among the green, yellow, and red mandarin, green mandarin showed four-times higher limonin (4.5 mg/L) than yellow and red mandarin (1.1 mg/L).…”

Section: Bioactive Compounds Of Citrus Fruitsmentioning

confidence: 99%

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Saini

Ranjit²,

Sharma³

et al. 2022

Antioxidants

136

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The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk of many diseases related to metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, and cancer. Citrus, the genus Citrus L., is one of the most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, and many other bioactive compounds of nutritional and nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class of bioactive flavonoids, abundantly occur in citrus fruits. In addition, citrus essential oil, rich in limonoids and terpenes, is an economically important product due to its potent antioxidant, antimicrobial, and flavoring properties. Mechanistic, observational, and intervention studies have demonstrated the health benefits of citrus bioactives in minimizing the risk of metabolic syndrome. This review provides a comprehensive view of the composition of carotenoids, flavonoids, terpenes, and limonoids of citrus fruits and their associated health benefits.

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Section: Bioactive Compounds Of Citrus Fruitsmentioning

confidence: 99%

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Saini

Ranjit²,

Sharma³

et al. 2022

Antioxidants

136

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“…A large number of analytical techniques to characterize the composition of Citrus essential oils were introduced in the literature, including GC-MS [2,7], high performance liquid chromatography coupled to UV detection or mass spectrometry (HPLC-UV and MS) [8], two-dimensional gas chromatography (GCxGC) [9], or spectroscopy such as infrared (IR) [10]. However, the reports of Citrus EO analysis by supercritical fluid chromatography (SFC) are still scarce [11,12], using UV or mass spectrometry detectors and mainly related to non-volatile polar compounds. The objective of this study is thus to compare the analytical performances of a gold-standard technology (used in NF ISO 855), i.e., gas chromatography (GC-FID), with that of packed-column SFC-UV.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Supercritical Fluid Chromatography Hyphenated to an Ultraviolet Detector and Gas Chromatography Hyphenated to a Flame Ionization Detector for Qualitative and Quantitative Analysis of Citrus Essential Oils

Santerre

Delannay

Franco³

et al. 2022

Separations

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A comparison between the classical gas chromatography (GC) technique with supercritical fluid chromatography (SFC) technology was performed using an essential oil of Citrus limon (lemon) as a model, considering its wide use in the cosmetic world. For the qualitative part, the signal annotation was achieved by mass spectrometry using either an electron ionization (EI) or an atmospheric pressure photoionization (APPI) source. For the quantitative part, GC was hyphenated to a flame ionization detector (GC-FID) and SFC to an ultraviolet detector (SFC-UV). The assay of the major component of citrus oil, i.e., limonene, was carried out by SFC-UV. The similar results obtained between GC-FID and SFC-UV allows SFC-UV to be considered as an alternative to GC-FID for Citrus oil characterization. Then, analyses of an essential oil collection from Citrus fruits were achieved to confirm the potential use of SFC-UV for oil classification in the context of quality control of raw materials in cosmetics.

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“…The most intriguing class of compounds is represented by limonoids, considered selective tetranortriterpenoid compounds present in citrus fruits as reported in the literature [ 11 ]. Limonoids are abundant in peels and seeds and exert different pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic, and insecticidal, among others [ 12 , 13 ]. One of the most studied, limonin, displayed good antiproliferative activity in the micromolar range, while its derivatives showed interesting anti-inflammatory and anti-nociceptive properties [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction, Chemical Characterization, and Impact on Cell Viability of Food Wastes Derived from Southern Italy Autochthonous Citrus Fruits

et al. 2022

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Citrus fruits are one of the principal fruits used to produce juices. Over the years, these fruits have been recognized as new health-promoting agents. In this work, food wastes derived from autochthonous citrus fruits of Southern Italy, named Limone di Rocca Imperiale, Arancia Rossa Moro, and Arancia Bionda Tardivo from Trebisacce, were analyzed. After fresh-squeezing juice, peel and pomace were employed to obtain six different extracts using an ultrasound-assisted method in a hydroalcoholic solvent. The extracts were analyzed in terms of qualitative composition, antioxidant properties, and antiproliferative activity on MCF-7, MDA-MB-231, and BJ-hTERT cell lines. GC-MS and LC-ESI-MS analyses showed different compounds: of note, limonin-hexoside, neodiosmin, obacunone glucoside, and diacetyl nomilinic acid glucoside have been identified as limonoid structures present in all the samples, in addition to different polyphenols including naringenin-glucoside, hesperetin-O-hexoside-O-rhamnoside-O-glucoside, diferuloyl-glucaric acid ester, chlorogenic acid, and the presence of fatty acids such as palmitic, myristic, and linoleic acids. These extracts were able to exert antioxidant activity as demonstrated by DPPH and ABTS assays and, although at higher doses, to reduce the cell viability of different solid tumor cell lines, as shown in MTT assays.

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Characterization of Limonoids in Citrus Essential Oils by Means of Supercritical Fluid Chromatography Tandem Mass Spectrometry

Cited by 10 publications

References 38 publications

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Comparison of Supercritical Fluid Chromatography Hyphenated to an Ultraviolet Detector and Gas Chromatography Hyphenated to a Flame Ionization Detector for Qualitative and Quantitative Analysis of Citrus Essential Oils

Ultrasound-Assisted Extraction, Chemical Characterization, and Impact on Cell Viability of Food Wastes Derived from Southern Italy Autochthonous Citrus Fruits

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