Characterization of lapachol in artificial organic-film membrane: Application for the trans-membrane transport of Mg2+

Ebelle, Christophe Thiery; Nassi, Achille; Njanja, Evangéline; Ngameni, Emmanuel

doi:10.1016/j.jelechem.2010.02.006

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…The inset of Figure 4 shows the variation of the scan rate-normalised cathodic peak current, , /V versus V, for cathodic peak II. The ratio /V for cathodic peak decreases severely with an increasing scan rate, indicating a CE mechanism in which the electrode reaction is gated by a slow preceding chemical step [15,26]. These results suggest that the two systems are not similar.…”

Section: Resultsmentioning

confidence: 90%

“…The modification and pretreatment of the working electrode were described elsewhere [15] as follow: the organic solution (1 L) was deposited on the graphite electrode with a micropipette; the organic solution spreads spontaneously over the electrode surface forming a stable film. The so-modified electrode was immersed in a phosphate buffer solution (0.1 M K 2 HPO 4 + 0.1 M KH 2 PO 4 ).…”

Section: Preparation Of the Filmmentioning

confidence: 99%

“…In many other research areas, such as pharmacology, these relationships are important, since they provide the basis for intelligent design of new drugs or treatments for specific diseases. The areas of research related to molecular, biochemical, and analytical electrochemistry for the analysis of reaction mechanisms and structure-reactivity relationships are of great importance in elucidating the human body's metabolic processing drugs and of the effect of drugs on the body [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Liposomes are also suitable for membrane immobilization of lipophilic benzophenone. In this context, we recently incorporated Lapachol to build an artificial light-driven transmembrane calcium pump and explain a new reduction mechanism of Lapachol in thinfilm electrode [15]. The aim of the work is to provide an insight in the redox chemistry of Gutifferone A, an important natural product embedded in an artificial membrane using the model developed by Shi and Anson [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Voltammetry Study of an Anti-HIV Compound by means of a Thin Organic Membrane

Nassi

Ebelle

Manga

et al. 2013

International Journal of Electrochemistry

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Cyclic and square wave voltammetries have been used to study electrochemical behaviour of an anti-HIV agent (Guttiferone A) at the liquid-liquid interface. The thin organic membrane is formed by an organic solvent containing redox probe. Guttiferone A, a benzophenone (BP) with appropriate electrolyte. It is demonstrated that BP possesses three reduction systems due to the redox transformation of the three tautomeric forms that lead to the migration of proton between the hydroxyl group in position 4 and the carbonyl group in positions 2 and 10. The transfer of proton from the aqueous solution to the organic phase is crucial for the redox transformation of BP into the organic membrane. The voltammograms obtained are strongly influenced by the pH of the aqueous phase. The electrochemical mechanism consists of 2e − /2H + exchange to form the separate redox compound BPH 2 .

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Section: Resultsmentioning

confidence: 90%

Section: Preparation Of the Filmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Voltammetry Study of an Anti-HIV Compound by means of a Thin Organic Membrane

Nassi

Ebelle

Manga

et al. 2013

International Journal of Electrochemistry

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“…In the recent study this approach was exploited to examine: electrochemical and spectroscopic behaviour of double-decker lutetium(III) phthalocyanines [4][5][6], the coupled electron-ion transfer reaction across liquid j liquid interface [2,[7][8][9] and the kinetic of the ion transfer across the liquid j liquid interface [10][11][12][13]. Generally for this study, an organic solvent is used, though most organic solvents are toxic and do not offer a wide range of electroactivity window.…”

Section: Introductionmentioning

confidence: 99%

Thin‐Film Voltammetry of a Lutetium Bisphthalocyanine at Ionic Liquid|Water Interface

et al. 2010

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At room temperature, tetraoctylphosphonium bromide is a viscous ionic liquid, this gel-like organic phase can be cast over a basal-plane graphite electrode (BPGE). Cyclic voltammetry at such a modified electrode, in contact with an aqueous solution have revealed one reversible oxidation and five reversible reduction steps for a Lu III bisphthalocyanine dissolved in the ionic liquid film, a proof that the highly reactive reduced species were protected from interaction with water in this highly lipophilic phase. It has also been shown that the redox properties are influenced by the ions in the aqueous phase, a property which has been attributed to ion-pairing effects; obviously, the ion transfers at the organic j aqueous interface has been ignored. Electrochemistry of Lu(III)[( t Bu) 4 Pc] 2 (cyclic voltammetry and square wave voltammetry) under similar conditions shows that the nature and concentration of the anion in the aqueous solution in contact with the ionic liquid film influences the potential of the electrode reaction. This can be attributed to variations of the interfacial potential and also because the organic phase is an anion exchanger. Moreover, SWV experiments suggest that the rate of the overall reaction varies with the nature and concentration of the anion of the aqueous electrolyte, which implies that the ion transfer through the organic j aqueous interface is slower than the electron exchange rate of the molecule at the surface of graphite.

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Electrochemical Study of DPPH Incorporated in Carbon Paste Electrode as Potential Tool for Antioxidant Properties Determination

et al. 2018

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The electrochemical behaviour of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) incorporated in a carbon paste electrode (CPE/DPPH1 %) was studied. Two electrochemical systems assigned to the free‐radical were perfectly defined, including System I where DPPH acts as reducing agent and System II where it acts as an oxidant. Although System II was reversible and remains stable after several consecutive potential scans, System I shows high peak current ratio (Ipa/Ipc=1.4) and a significant decrease in signal intensity when performing consecutive potentials scans. This phenomenon was due to the chemical reaction of the oxidized DPPH and the hydroxide ions present at the vicinity of the electrode surface. This new compound formed was responsible of a new system (System III). Systems II and III were highly pH‐dependent, in agreement with the proton exchange involved in these electrochemical transformations. When experiments were performed in the presence of ascorbic acid (AAH2), only System I was found to be ideal for monitoring the antioxidant activity of AAH2. System I clearly shows a linear dependency between the peak currents of DPPH as a function of AAH2 concentration. This linear response was used to determine the IC50 of ascorbic acid (0.56 μM) in the described experimental condition. This effect was confirmed when controlled amount of tea extracts were used instead of AAH2, confirming the efficiency of CPE/DPPH1 % for the electrochemical evaluation of antioxidant properties.

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Characterization of lapachol in artificial organic-film membrane: Application for the trans-membrane transport of Mg2+

Cited by 6 publications

References 30 publications

Voltammetry Study of an Anti-HIV Compound by means of a Thin Organic Membrane

Voltammetry Study of an Anti-HIV Compound by means of a Thin Organic Membrane

Thin‐Film Voltammetry of a Lutetium Bisphthalocyanine at Ionic Liquid|Water Interface

Electrochemical Study of DPPH Incorporated in Carbon Paste Electrode as Potential Tool for Antioxidant Properties Determination

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