Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke

Segev, Gil; Daminet, Sylvie; Meyer, Evelyne; Loor, Jorien De; Cohen, Aviv; Aroch, Itamar; Bruchim, Yaron

doi:10.1016/j.tvjl.2015.07.004

Cited by 45 publications

(59 citation statements)

References 35 publications

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“…Heatstroke often is complicated by AKI, which adversely affects mortality in dogs . Although, based on IRIS criteria, only 55% of the dogs in our study had AKI, previous studies using biomarkers with higher sensitivity compared with sCr concentration (which is a functional marker) or by histopathology of renal tissue in fatal cases of heatstroke in dogs both suggest that AKI is invariably present in these animals …”

Section: Discussionmentioning

confidence: 55%

Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke

Segev

Bruchim

Berl

et al. 2018

Veterinary Internal Medicne

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BackgroundAcute kidney injury (AKI) is common in dogs, but evidence of efficacy of its treatment is lacking.ObjectiveTo evaluate the efficacy of fenoldopam in the management of AKI.AnimalsForty dogs with naturally occurring heatstroke.MethodsDogs were prospectively enrolled and divided into treatment and the placebo groups (fenoldopam, constant rate infusion [CRI] of 0.1 µg/kg/min or saline, respectively). Urine production (UP) was measured using a closed system. Urinary clearances were performed at 4, 12, and 24 hours after presentation to estimate the effect of fenoldopam on UP, glomerular filtration rate (GFR) and sodium fractional excretion (NaFE).ResultsAt presentation, severity of heatstroke, based on a previously developed scoring system, was similar between the study groups, but was significantly worse in nonsurvivors compared with survivors. Fenoldopam administration was not associated with hypotension. Overt AKI was diagnosed, based on the International Renal Interest Society guidelines in 22/40 (55%) of the dogs. Overall, 14/40 dogs (35%) died, with no significant (P = .507) mortality rate difference between the fenoldopam (6/20 dogs; 30%) and placebo (8/20; 40%) groups. The proportion of dogs with AKI did not differ between the fenoldopam and the placebo groups (9/20; 45% versus 13/20; 65%, respectively; P = .204). There were no differences in UP, GFR, and NaFE between the fenoldopam and the placebo groups.Conclusion and Clinical ImportanceFenoldopam CRI at 0.1 µg/kg/min did not have a clinically relevant effect on kidney function parameters in dogs with severe heatstroke‐associated AKI.

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Section: Discussionmentioning

confidence: 55%

Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke

Segev

Bruchim

Berl

et al. 2018

Veterinary Internal Medicne

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“…4,24,25,26 Similar efforts are underway in veterinary medicine and show great promise. [28][29][30][31][32][33][34][35][36] (See also, Yerramilli in this issue) An AKI biomarker should be detectable in urine and/or plasma such that it can be assessed routinely and serve as an indicator of kidney function or dysfunction or response to injury. The ideal marker should reflect kidney specific events, be unique and specific to the kidney, and reflect very early and potentially sustained phases of the pathogenesis and repair processes.…”

Section: Identification Of Progressive Ckd: the Search For Active Injmentioning

confidence: 99%

“…29,30,31,34 (Figure 3) In dogs with naturally acquired urinary tract disease, urinary NGAL was a highly sensitive and specific predictor of AKI including dogs categorized as IRIS AKI Grade I. 30 In collaboration with IDEXX Laboratories, the one of the authors c similarly has …”

Section: Kidney Injurymentioning

confidence: 99%

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Cowgill

Polzin

Elliott

et al. 2016

Veterinary Clinics of North America: Small Animal Practice

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“…Acute kidney injury is gaining attention in small animal medicine, but universally accepted diagnostic criteria are lacking . Recently, an AKI grading system for dogs was proposed by Cowgill, accepted by the IRIS group (http://www.iris-kidney.com/pdf/grading-of-acute-kidney-injury.pdf), and applied in clinical settings . Diagnostic criteria and five AKI grades based on medical data, sCr concentrations, and UO are suggested.…”

Section: Introductionmentioning

confidence: 99%

“…Fractional excretion of electrolytes have been recently re‐evaluated in dogs with AKI as readily available and cost‐effective markers of tubular damage and kidney function . Fractional excretion of sodium was an early and accurate predictor of AKI in a population of dogs with naturally occurring heatstroke despite fluid resuscitation .…”

Section: Introductionmentioning

confidence: 99%

Fractional excretion of electrolytes in volume‐responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications

Troìa

Gruarin

Grisetti

et al. 2018

Veterinary Internal Medicne

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BackgroundThe value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs.ObjectivesTo evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI.AnimalsDogs (n = 135) with AKI treated with standard care (February 2014‐December 2016).MethodsProspective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission. Dogs were graded according to the AKI‐IRIS guidelines and grouped according to AKI features (volume‐responsive, VR‐AKI; intrinsic, I‐AKI) and outcome (survivors/non‐survivors). Group comparison and regression analyses with hazard ratios (HR) evaluation for I‐AKI and mortality were performed. P < .05 was considered significant.ResultsFifty‐two of 135 (39%) dogs had VR‐AKI, 69/135 (51%) I‐AKI and 14/135 (10%) were unclassified. I‐AKI dogs had significantly higher FE of electrolytes, for example, FE of sodium (FENa, %) 2.39 (range 0.04‐75.81) than VR‐AKI ones 0.24 (range 0.01‐2.21; P < .001). Overall, case fatality was 41% (55/135). Increased FE of electrolytes were detected in nonsurvivors, for example, FENa 1.60 (range 0.03‐75.81) compared with survivors 0.60 (range 0.01‐50.45; P = .004). Several risk factors for death were identified, including AKI‐IRIS grade (HR = 1.39, P = .002), FE of electrolytes, for example, FENa (HR = 1.03, P < .001), and urinary output (HR = 5.06, P < .001).Conclusions and Clinical ImportanceFractional excretion of electrolytes performed well in the early differentiation between VR‐AKI and I‐AKI, were related to outcome, and could be useful tools to manage AKI dogs in clinical practice.

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Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke

Cited by 45 publications

References 35 publications

Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke

Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Fractional excretion of electrolytes in volume‐responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications

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