Characterization of insomnia in patients with essential hypertension

Prejbisz, Aleksander; Kabat, Marek; Januszewicz, Andrzej; Szelenberger, Waldemar; Piotrowska, A; Piotrowski, Walerian; Piwoński, Jerzy; Makowiecka-Cieśla, Magdalena; Widecka, Krystyna; Patera, Bożena; Bieniaszewski, Leszek; Narkiewicz, Krzysztof; Tykarski, Andrzej; Piejko, Anna; Grodzicki, Tomasz; Czerwieńska, Beata; Wiȩcek, Andrzej

doi:10.1080/08037050600963040

Cited by 35 publications

(32 citation statements)

References 15 publications

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“…There are only limited studies available to compare the rate of insomnia in patients with hypertension with that of our data. 19,20 In this study, the prevalence of insomnia among hypertensive population was found to be 47.2%. This observation corroborated with the prevalence reported in a European population.…”

Section: Discussionmentioning

confidence: 53%

“…This observation corroborated with the prevalence reported in a European population. 20 However, in another study (POL-MONICA BIS) in Warsaw metropolitan population, prevalence of insomnia was found to be low (30.7%). 19 Nevertheless, it should be noted that the prevalence of insomnia reported in this study among patients who reached out to physicians for the management of hypertension was higher than reported in general Indian population, indicating the lack of relevance given by healthcare professionals towards the condition.…”

Section: Discussionmentioning

confidence: 90%

“…This result is in accord with prior research which suggests that women are more likely to have insomnia. 20,21 There could be a possibility that variations in estrogen contribute to these differences in the expression of insomnia. 22 Greater BMI and obesity has also been linked with the diagnosis of insomnia.…”

Section: Discussionmentioning

confidence: 99%

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A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

Karnik¹,

Peethambaran²,

Adsule³

2017

Int J Res Med Sci

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Background: Hypertension is a leading risk factor affecting mortality and disability-adjusted life years worldwide. The objective of the study was to determine the prevalence of insomnia, co-morbid medical conditions, lifestyle attributes, related sleep habits and sleep quality among Indian hypertensive patients.Methods: Adults (≥18 years) with newly diagnosed or known history of hypertension, willing to participate were enrolled in this cross-sectional, epidemiological study. Several variables including lifestyle attributes, sleep habits, quality, medications, demographics, medical/surgical history and other details pertaining to hypertension were analyzed. Insomnia was assessed by Athens Insomnia Scale (AIS) in patients not identified in the past one month.Results: All the 657 enrolled patients completed the study (mean age: 55.4±11.61 years; men: 53.7%; women: 46.3%). Prevalence of insomnia among hypertensive population was approximately 47.2% (n=310; 95% CI: 43.4, 51.0). Number of patients newly diagnosed with insomnia by AIS scale was higher compared with patients already diagnosed with insomnia (34.9% [95% CI: 31.2, 38.5] vs. 12.3% [95% CI: 9.81, 14.8]). Common medical conditions associated with hypertension were diabetes mellitus (61.1%) and dyslipidemia (28.3%). More than half of the hypertensive patients with insomnia had sleep-related problems once or twice a week. Further, the daytime impact of insufficient sleep on wellbeing and functioning was markedly decreased in insomniac patients.Conclusions: Prevalence of insomnia among patients suffering from hypertension was higher than that reported in general Indian population in various studies. Present study shows that about 75% insomniac cases were undiagnosed, indicating that insomnia diagnosis may have been missed in a large proportion of hypertensive patients.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 90%

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A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

Karnik¹,

Peethambaran²,

Adsule³

2017

Int J Res Med Sci

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“…Recordings contain 21 EEG channels from the 10-20 system plus A1/A2 references, two EOG channels (EOGL and EOGR), breathing, EMG and ECG; with sampling frequency 128 Hz. These datasets come from several different projects, including studies of effect of diazepam and midazolam (Durka et al 2002), hypertension (Prejbisz et al 2006), insomnia Niemcewicz 2000, 2001;Niemcewicz et al 2001) and clinical depression (Dróżdż et al 2007;Radziwoń-Zaleska et al 2006), both from control and from target groups.…”

Section: Experimental Datamentioning

confidence: 99%

On the Robust Parametric Detection of EEG Artifacts in Polysomnographic Recordings

et al. 2009

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We present an open, parametric system for automatic detection of EEG artifacts in polysomnographic recordings. It relies on independent parameters reflecting the relative presence of each of the eight types of artifacts in a given epoch. An artifact is marked if any of these parameters exceeds a threshold. These thresholds, set for each parameter separately, can be adjusted via "learning by example" procedure (multidimensional minimization with computationally intensive cost function), which can be used to automatically tune the parameters to new types of datasets, environments or requirements. Performance of the system, evaluated on 103 overnight polysomnographic recordings, revealed concordance with decisions of human experts close to the inter-expert agreement. To make this statement well defined, we review the methodology of evaluation for this kind of detection systems. Complete source code is available from http://eeg.pl; a user-friendly version with Java interface is available from http://signalml.org.

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“…1-4 Indeed, a great many of hypertensive patients suffer additional distress because of poorer quality sleep, 5-7 and the degree of poor sleep quality is associated with the severity of the hypertension. [7][8][9][10] These observations suggest the possibility that hypertension and the disrupted sleep might share a common etiology, namely adrenergic overdrive. However, the pathophysiology behind sleep disturbance related to essential hypertension is much less well understood.…”

mentioning

confidence: 93%

Sleep Disturbance Among Spontaneously Hypertensive Rats is Mediated by an α1-Adrenergic Mechanism

et al. 2012

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nature publishing group original contributionsInsomniacs are known to have a higher risk of developing hypertension, but less attention has been focused on patients with hypertension with respect to the further aggravation of the hypertensive states because of poor quality sleep. 1-4 Indeed, a great many of hypertensive patients suffer additional distress because of poorer quality sleep, 5-7 and the degree of poor sleep quality is associated with the severity of the hypertension. [7][8][9][10] These observations suggest the possibility that hypertension and the disrupted sleep might share a common etiology, namely adrenergic overdrive. However, the pathophysiology behind sleep disturbance related to essential hypertension is much less well understood.An association between sympathetic hyperactivity and sleep disturbance has been shown in a rodent model of essential hypertension, spontaneously hypertensive rats (SHR). 11 Compared with normotensive rats, SHR sleeps poorly in terms of fewer episodes, shorter accumulated time and more interruption of quiet sleep (QS; synonymous with non-rapid eye movement sleep), 11 with sympathetic hyperactivity more evident than while awake. The norepinephrine levels are higher in the cerebrospinal fluid of hypertensive patients 12,13 and rats, 14 as well as in some brain areas of SHR. [15][16][17] Norepinephrine is an important monoamine that promotes arousal, and therefore this increased norepinephrine secretion in individuals with essential hypertension might be responsible for not only their elevated blood pressure but also their poorer quality of sleep.Several attempts have been made to investigate the acute effect of adrenergic agonists or antagonists on sleep-wake cycles in normotensive rats; however, the results were inconsistent. 18 In this context, QS time has been found to be prolonged by α1-antagonists and shortened by α1-agonists, 19,20 whereas no consistent modification to QS has been observed the first two authors contributed equally to this paper. BackgroundInadequate sleep may aggravate hypertension, but the pathophysiology of sleep disturbance in hypertension remains unknown. Among spontaneously hypertensive rats (SHr), sleep disturbance co-occurred with sympathetic hyperactivity; therefore, we hypothesized that the sleep disturbance can be alleviated by antagonizing the adrenergic overdrive.

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Characterization of insomnia in patients with essential hypertension

Cited by 35 publications

References 15 publications

A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

On the Robust Parametric Detection of EEG Artifacts in Polysomnographic Recordings

Sleep Disturbance Among Spontaneously Hypertensive Rats is Mediated by an α1-Adrenergic Mechanism

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