Characterization of IL-17+Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis

Peng, Yi; Han, Gencheng; Shao, Hui; Wang, Yali; Kaplan, Henry J.; Sun, Deming

doi:10.1167/iovs.07-0251

Cited by 110 publications

(140 citation statements)

References 47 publications

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“…[12][13][14] In the previous study, we reported that both IL-17 + and IFN-γ + IRBP-specific T cells are uveitogenic. 15) Meanwhile, we found that in QKL group and Dex group, the differentiation of IFN-γ-expressing CD4 + T cells and IL-17-expressing CD4 + T cells are lower than control cells. We also observed that the relative expression of Th1-and Th17-cytokines at the mRNA level were markedly reduced after treatment with Qingkailing injection and Dexamethasone.…”

Section: Discussionmentioning

confidence: 84%

Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats via Inhibiting Th1 and Th17 Effector Cells

Tian

Cui

et al. 2012

Biological & Pharmaceutical Bulletin

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Qingkailing injection is a well-known composite formula of traditional Chinese medicine and is commonly used in clinical practice, which could offer immunomodulatory effect from our clinical experience on uveitis treatment by Qingkailing. We did the experiment in order to investigate the curative effect and mechanism of Qingkailing injection to rat experimental autoimmune uveitis (EAU). EAU was induced in Lewis rats by immunization IRBP1177-1191 in complete Freund's adjuvant in multi-point. We found that Qingkailing injection can alleviate autoimmune uveitis in rats, inhibit the differentiation toward Th1 and Th17 effector cells and the relevant cytokines secretion. The therapeutic effect may also be regulated through increased secretion of interleukin (IL)-10.

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Section: Discussionmentioning

confidence: 84%

Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats via Inhibiting Th1 and Th17 Effector Cells

Tian

Cui

et al. 2012

Biological & Pharmaceutical Bulletin

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“…In the model of experimental autoimmune encephalomyelitis, the antigen specific Th17 cells were reported (21), and in the model of experimental autoimmune uveitis, both the antigen-specific and non-antigen specific Th17 cells were present (22). To explore whether the production of IL-17 by γδ T cells is antigen specific or not, we expanded peripheral blood γδ T cells from PBMCs cultured with M. tb-HAg that predominantly stimulate human γδ T cells in vitro, and found the expanded γδ T cells differentiated into effective cells.…”

Section: Discussionmentioning

confidence: 99%

Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis

et al. 2008

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Although it has been known that γδ T cells may play an important role in the immune response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the γδ T cells participate in the innate and/or acquired immunity to tuberculosis (TB) have not been full elucidated. In the present study, 27 patients with active pulmonary TB and 16 healthy donors (HD) were performed. We found that proportion of IL-17-producing cells among lymphocyte was similar between TB patients and HD, whereas the proportions of γδ T cells in IL-17-producing cells (59.2%) and IL-17-producing cells in γδ T cells (19.4%) in peripheral blood were markedly increased in TB patients when compared to those in HD (43.9% and 7.7%, respectively). In addition, the proportions of IFN-γ-producing γδ T cells in TB patients were obviously lower than that in HD. Upon re-stimulated with M. tb heat-treated antigen (M. tb-HAg) in vitro, fewer IL-17-producing γδ T cells were generated from HD and TB patients, whereas IFN-γ-producing γδ T cells were increased in TB patients compared to that in HD. Our findings in TB patients and healthy human were consistent with other murine investigation that the IL-17-producing γδ T cells were main source of IL-17 in mouse model of BCG infection, suggesting that γδ T cells might be involved in the formation of tubercular granuloma in pulmonary TB patients, but need further identification.

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“…Notably, in patients, CD8 + T cells producing IL-17 can be identified in chronic inflammatory lesions such as psoriatic lesions (32) and multiple sclerosis plaques (30). Animal models corroborate the implication of IL-17-producing CD8 + T cells in a wide variety of immune conditions (22,(33)(34)(35)(36). Adoptive transfer experiments of Tc17 cells have suggested that their ability to clear influenza virus and to protect against tumor are related to the plasticity of the Tc17 lineage (22,37).…”

mentioning

confidence: 86%

Tc17 CD8+ T Cells Potentiate Th1-Mediated Autoimmune Diabetes in a Mouse Model

Saxena

Desbois

Carrié

et al. 2012

The Journal of Immunology

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An increase in IL-17–producing CD8+ T (Tc17) cells has been reported in the peripheral blood of children with recent onset type 1 diabetes (T1D), but their contribution to disease pathogenesis is still unknown. To directly study the pathogenic potential of β cell-specific Tc17 cells, we used an experimental model of T1D based on the expression of the neo-self Ag hemagglutinin (HA) in the β cells of the pancreas. When transferred alone, the IL-17–producing HA-specific CD8+ T cells homed to the pancreatic lymph nodes without causing any pancreatic infiltration or tissue destruction. When transferred together with small numbers of diabetogenic HA-specific CD4+ T cells, a strikingly different phenotype developed. Under these conditions, Tc17 cells sustained disease progression, driving the destruction of β-islet cells, causing hyperglycemia and ultimately death. Disease progression did not correlate with functional or numerical alterations among the HA-specific CD4+ T cells. Rather, the transferred CD8+ T cells accumulated in the pancreatic islets and a considerable fraction converted, under the control of IL-12, to an IFN-γ–producing phenotype. Our data indicate that Tc17 cells are not diabetogenic but can potentiate a Th1-mediated disease. Plasticity of the Tc17 lineage is associated with transition to overt disease in this experimental model of T1D.

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Characterization of IL-17⁺Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis

Abstract: IL-17(+) T cells can be readily detected among activated autoreactive and bystander T cells and may play a major role in the pathogenesis of EAU.

Cited by 110 publications

References 47 publications

Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats <i>via</i> Inhibiting Th1 and Th17 Effector Cells

Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats <i>via</i> Inhibiting Th1 and Th17 Effector Cells

Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis

Tc17 CD8+ T Cells Potentiate Th1-Mediated Autoimmune Diabetes in a Mouse Model

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