Characterization of hydroxyapatite-tantalum pentoxide nanocomposite coating applied by electrophoretic deposition on Nitinol superelastic alloy

Horandghadim, Nazila; Khalil‐Allafi, Jafar

doi:10.1016/j.ceramint.2019.02.105

Cited by 21 publications

(8 citation statements)

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“…1,[4][5][6] Among them, tantalum (Ta) has been used for implants in both orthopedics and dentistry. [7][8][9] Ta nanomaterials are increasingly being explored as alternatives to metals with good biocompatibility in the manufacture of implantable medical devices. 8,10 However, there are few studies on the bone regeneration induced by Ta nanoparticles (Ta NPs).…”

Section: Introductionmentioning

confidence: 99%

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Zhang¹,

Liu²,

Wang³

et al. 2020

IJN

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Background: In recent years, nanomaterials have been increasingly developed and applied in the field of bone tissue engineering. However, there are few studies on the induction of bone regeneration by tantalum nanoparticles (Ta NPs) and no reports on the effects of Ta NPs on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and the underlying mechanisms. The main purpose of this study was to investigate the effects of Ta NPs on bone regeneration and BMSC osteogenic differentiation and the underlying mechanisms. Materials and Methods: The effects of Ta NPs on bone regeneration were evaluated in an animal experiment, and the effects of Ta NPs on osteogenic differentiation of BMSCs and the underlying mechanisms were evaluated in cell experiments. In the animal experiment, hematoxylin-eosin (HE) staining and hard-tissue section analysis showed that Ta NPs promoted bone regeneration, and immunohistochemistry revealed elevated expression of BMP2 and Smad4 in cells cultured with Ta NPs. Results: The results of the cell experiments showed that Ta NPs promoted BMSC proliferation, alkaline phosphatase (ALP) activity, BMP2 secretion and extracellular matrix (ECM) mineralization, and the expression of related osteogenic genes and proteins (especially BMP2, Smad4 and Runx2) was upregulated under culture with Ta NPs. Smad4 expression, ALP activity, ECM mineralization, and osteogenesis-related gene and protein expression decreased after inhibiting Smad4. Conclusion: These data suggest that Ta NPs have an osteogenic effect and induce bone regeneration by activating the BMP2/Smad4/Runx2 signaling pathway, which in turn causes BMSCs to undergo osteogenic differentiation. This study provides insight into the molecular mechanisms underlying the effects of Ta NPs in bone regeneration.

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Section: Introductionmentioning

confidence: 99%

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Zhang¹,

Liu²,

Wang³

et al. 2020

IJN

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“…This result can be interpreted considering a stabilization of tantalum NPs by means of gelatin chains due to electrostatic interactions. In fact, Type A gelatin used in this work has an isoelectric pH of 8.4, meaning that the biopolymer is positively charged under the composite preparation conditions (measured pH= 7.2) while tantalum NPs might be negatively charged at this pH value, as suggested in literature [39]. Rapid gelation of the hydrogel further stabilizes the nanoparticles dispersion, thus preventing aggregation phenomena, which is one of the main issues to be considered during the preparation process of nanocomposite hydrogels [40,41] The findings on homogeneous tantalum NPs dispersion were further confirmed by the topographic characterization of the composite surfaces by means of atomic force microscopy (Fig.…”

Section: Resultsmentioning

confidence: 66%

Tantalum nanoparticles enhance the osteoinductivity of multiscale composites based on poly(lactide-co-glycolide) electrospun fibers embedded in a gelatin hydrogel

Liguori

Gino

Panzavolta

et al. 2022

Materials Today Chemistry

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“…Composing the HA coating with Ti improved the coating density, which is due to the reaction bonds occurring during the sintering process (Figure ). By enhancing the density of the coating and subsequently reducing the amount of porosity in the material, the ions transformation from the corrosive environment to the coating will be substantially suppressed (Horandghadim & Khalil‐Allafi, ; Maleki‐Ghaleh & Khalil‐Allafi, ). In the composite specimens, by increasing the milling time of the HA composite powder from 2 to 4 hr, the amount of micro‐porosity and grain boundaries decreased, which resulted in increasing the electrochemical resistance in the composite coatings.…”

Section: Discussionmentioning

confidence: 99%

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

et al. 2019

Self Cite

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In the present work, hydroxyapatite (HA)-titanium (Ti, 20 wt%) composite coating was coated on NiTi alloy substrate by EPD (electrophoretic deposition) process.Before applying the coating, the HA powder was composed with Ti powder using a ball milling process. Influence of the ball milling time on morphology and phase structure of HA-Ti powder was evaluated using TEM and XRD analysis. After composing the HA particles with Ti, the HA-Ti composite powders were coated on the NiTi substrate by the EPD process in an n-butanol medium for 2 min, with the applied voltage of 60 V. XRD and SEM analysis were utilized to evaluate the phase analysis and morphology of the coatings. Mechanical and electrochemical characteristic of the coatings were also assessed using the micro-indentation, micro-scratch, and polarization tests, respectively. The results revealed that the milling process time had a significant influence on reaction bonds and optimum mixing time was 4 hr. Micro-hardness of the HA-Ti composite coating (304 HV) was substantially higher than the HA coating (72 HV). Also, as the HA coating was composed with Ti particles, the amount of force (in the micro-scratch test) required for detaching the coating from the NiTi substrate increased from 7.1 to 17.8 N. The polarization results showed that the HA-Ti composite coating had a higher electrochemical resistance compared with the HA coating. Corrosion resistance of the NiTi alloy coated with HA increased from 133 kΩ. cm 2 to 2,720 kΩ.cm 2 after composed with the Ti particles.

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Characterization of hydroxyapatite-tantalum pentoxide nanocomposite coating applied by electrophoretic deposition on Nitinol superelastic alloy

Cited by 21 publications

References 75 publications

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

<p>The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway</p>

Tantalum nanoparticles enhance the osteoinductivity of multiscale composites based on poly(lactide-co-glycolide) electrospun fibers embedded in a gelatin hydrogel

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

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