Characterization of hydrochloride and tannate salts of diphenhydramine

Abstract

Proper characterization is an important aspect of any dosage form design. The objective of this work was to characterize tannate salt and hydrochloride salt of diphenhydramine. As a part of characterization studies, Differential scanning calorimetry was used to investigate thermal effects and nature of salts, supported by X-ray powder diffraction. Scanning electron microphotographs was used to surface topography of salts of diphenhydramine. Fourier-transform infrared spectroscopy, solubility study and flowability studies were carried out as part of characterization. Differential scanning calorimetry and X-ray powder diffraction studies indicated amorphous nature of the tannate while hydrochloride salt has crystalline properties. Scanning electron microphotographs indicated the differences in surface topography between both the salts. Solubility studies at different pH showed pH dependant solubility of both the salts and less solubility of tannate. Stability of bulk drug at accelerated conditions of 40°/75% RH was determined for both salts. Good stability of both salts was observed.

Evaluation of Drug Release Profile from Patches Based on Styrene–Isoprene–Styrene Block Copolymer: The Effect of Block Structure and Plasticizer

“…The spectrum is found to be similar with For DPH, the peaks in the range of 2,400-2,700 cm −1 are attributed to the stretching vibrations of -N(CH 3 ) 2 ·HCl bond, while the peak at 1,103 cm −1 represents the O-CH 3 stretching vibration (24). No peaks in the range of 2,400-2,700 cm −1 are observed in the matrix-drug blends, implying the deformation of ionic bonds between hydrochloric acid and dimethylamino, when DPH be loaded in the matrix.…”

Removal of diphenhydramine from water by swelling clay minerals

“…8). The first and third was assigned to C-H out-of-plane bending vibration of monosubstitutes phenyl on a few studies [36,37], while the latter two were assigned to C-H out of plane deformation of monosubstituted phenyl [3]. The same three wavenumbers were found for the physical mixture although the peaks were much smaller.…”

“…DPH belongs to the class of ethanolamine H1 receptor antagonist and possesses a significant anticholinergic effect in addition to antihistaminic activity [3]. It is produced under the trade name Benadryl, and commonly used motion sick pills also contain DPH, although in combination with 8-chlorotheophylline to reduce the drowsiness created by DPH.…”

Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis

“…Characterisation of drug and polymer was performed by using FTIR (Shimadzu-8400S) discussed by Nandgude and Bhise [8] and DSC (PerkinElmer-4000) discussed by Nandgude et al [9]. …”