Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis

Abstract

In the present study bilayer patch of benzydamine HCl was developed using solvent casting method. Different substrates were attempted like Petri dish, glass-and-ring, and teflon-and-ring for selection of the proper option to formulate patch that should give easily peelable film with adequate mechanical properties. HPMC E15 LV was used in different concentrations for obtaining proper viscosity of solution for pouring on to surface and ring, that it should not leak from ring. The second layer was optimized by using different polymer like eudragit RSPO, eudragit RSPO + EC, and eudragit NE30 D for efficient layer bonding. The minimum release from backing membrane was established by diffusion study as compared to from drug loaded layer. The optimized batches were evaluated for folding endurance, weight variation, thickness, drug content, drug release, tensile strength, layer separation, mucoadhesion, moisture uptake, and layer bonding. The novel gingival patch of benzydamine HCl developed would be beneficial in optimizing the therapy.

Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method

“…ODFs are conventionally manufactured via film casting of the dispersion using different technologies. The most widely used technique is a solvent casting method that takes place in an aqueous or hydro-alcoholic mixture of excipients with API being casted onto a surface, dried, and cut into the desired size (12,20). The solvent casting method is relatively easily performed with no need for expensive equipment (21).…”

Development and optimization of cosolvent-based blended Sertraline orodispersible films - A step to personalized medicine

“…Sci. 2022;58: e20584 Dalia M N Abouhussein, Mohamed A El Nabarawi, Samia H Shalaby, Ahmed Abd El-Bary and API in an aqueous or hydro-alcoholic solution then casting onto a surface, drying, and cutting into the preferred size (Borges et al, 2015;Sanghai, Nandgude, Poddar, 2016).…”

Mucoadhesive chitosan–methylcellulose oral patches for the treatment of local mouth bacterial infections

“…To date, a wide range of polymeric drug delivery systems for oral applications have been reported in the literature, including but not limited to tablets, 12 gels, 13,14 patches, 15,16 and films. 17,18 In this context, oral films and patches may be preferred over other adhesive systems as they are flexible and soft, yet strong enough and with relevant mucoadhesive characteristic to withstand the stresses within the oral cavity.…”