Characterization of host response, resorption, and strength properties, and performance in the presence of bacteria for fully absorbable biomaterials for soft tissue repair

Stoikes, Nathaniel; Scott, Jeffrey R.; Badhwar, Amit; Deeken, Corey R.; Voeller, Guy

doi:10.1007/s10029-017-1638-3

Cited by 35 publications

(26 citation statements)

References 19 publications

(34 reference statements)

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“…4D) [74], to composites and to laminate patches [75]. The available data on this topic indicates that such observations are true for synthetic meshes made of both permanent [69,74] and biodegradable polymers [73].…”

Section: Guidance Based On Selection Of Appropriate Mesh Compositionmentioning

confidence: 88%

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Guillaume

Pérez‐Tanoira

Fortelny³

et al. 2018

Biomaterials

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The incidence of mesh-related infection after abdominal wall hernia repair is low, generally between 1 and 4%; however, worldwide, this corresponds to tens of thousands of difficult cases to treat annually. Adopting best practices in prevention is one of the keys to reduce the incidence of mesh-related infection. Once the infection is established, however, only a limited number of options are available that provides an efficient and successful treatment outcome. Over the past few years, there has been a tremendous amount of research dedicated to the functionalization of prosthetic meshes with antimicrobial properties, with some receiving regulatory approval and are currently available for clinical use. In this context, it is important to review the clinical importance of mesh infection, its risk factors, prophylaxis and pathogenicity. In addition, we give an overview of the main functionalization approaches that have been applied on meshes to confer anti-bacterial protection, the respective benefits and limitations, and finally some relevant future directions.

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Section: Guidance Based On Selection Of Appropriate Mesh Compositionmentioning

confidence: 88%

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Guillaume

Pérez‐Tanoira

Fortelny³

et al. 2018

Biomaterials

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“…The ECM thickness was measured by using the Masson trichrome stain, based on Skytec TRM-1-IFU's collagen Trichrome Stain (Connective Tissue Stain) [ 18 ] collagen deposition and quantified with ImageJ version 1.51j8 RRID: SCR_003070 [ 19 ]. Modified intra-abdominal adhesion scoring for laparoscopy [ 2 ] was used ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Laparoscopic procedures impact on mast cell mediators, extracellular matrix and adhesion scoring system in rats

Poerwosusanta

Gunadi²,

Oktaviyanti

et al. 2020

Annals of Medicine and Surgery

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Background Laparoscopic procedures under certain pressure have the potential to cause intra-abdominal adhesions. However, the pathomechanism of this disorder is unknown. Release of mast cell mediators due to mast cell degranulation is thought to be the cause. Materials and methods Thirty male Sprague-Dawley rats were grouped into five groups (n = 6 per group): one control group and four intervention groups to which 60 min insufflation was performed using carbon dioxide at 5, 8, 10 and 12 mmHg. Seven days after laparoscopy, we euthanized and evaluated the levels of histamine, tryptase, and chymase of peritoneal fluid, the thickness of ECM of peritoneal tissue, and intraabdominal adhesion scoring system. Results Histamine and tryptase levels in peritoneal fluid were significantly higher at the 10- and 12 mm Hg intervention compared to control (histamine: 0.50 ± 0.35 vs. 0.41 ± 0.41 vs. 0.04 ± 0.02 ng/mL, respectively; and tryptase: 0.69 ± 0.11 vs. 0.65 ± 0.05 vs. 0.48 ± 0.02 ng/ml respectively). The ECM was significantly thicker in the intervention groups at 10- and 12-mm Hg compared to control (71.3 [66.7–85.2] vs. 48.4 [34.5–50.3] vs. 10.25 [8.7–12.1] μm, respectively). Moreover, the intra-abdominal scoring was also significantly higher in the intervention groups at 10- and 12 mm Hg compared to control (4 [0–4] vs. 4.5 [4–5], vs. 0, respectively). Conclusions Laparoscopic procedures increase the release of mast cell mediators in peritoneal fluid, the thickness of ECM and intraabdominal adhesion scoring in rats, implying that it might increase the possibility of intrabdominal adhesion in humans.

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“…While not common in clean surgical procedures, when synthetic polymer mesh does become infected, the treatment often requires surgical removal of the mesh with devastating consequences as a result of the need to excise large areas of tissue (Hawn et al, 2011;Sanchez et al, 2011;Vagholkar et al, 2016). With degradable synthetic polymers, the risks appear similar until the material is degraded and absorbed and therefore can vary by the absorption time (Sahoo et al, 2017;Stoikes et al, 2017).…”

Section: Post-implantation Properties With Infectionmentioning

confidence: 99%

Clinically available reinforcing materials for soft tissue reconstruction

2020

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Navigating the rapidly evolving field of materials for soft tissue reinforcement is challenging given the volume of clinically available options. Additionally, the current generally accepted classifications of these mesh materials confound the understanding of their utility by grouping disparate materials that have attributes overlapping category boundaries and that do not fully consider their clinically functionality. This review article highlights, from a materials science perspective, the most important attributes of these materials to improve the clinical decision-making process in the selection of the most appropriate features and design for the patient, surgery and clinical need. These characteristics include the physical attributes that directly impact the surgical procedure and immediate postoperative mechanical requirements as well as the post-implantation properties such as an adequate reinforcement time, strength of the resulting tissue and infection risk profile.

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Characterization of host response, resorption, and strength properties, and performance in the presence of bacteria for fully absorbable biomaterials for soft tissue repair

Cited by 35 publications

References 19 publications

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Laparoscopic procedures impact on mast cell mediators, extracellular matrix and adhesion scoring system in rats

Clinically available reinforcing materials for soft tissue reconstruction

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