A novel, integrated photonic device has been demonstrated, which combines a microstructured optical fiber (MOF) and a Whispering-Gallery Mode (WGM) microsphere resonator encapsulated inside one of its capillaries. Studies have been focused on the light coupling to and from the micro-resonator, as well as, the resonating properties of such a photonic system. Spectral resonation in a spectral band spanning between 500 nm -1600 nm has been observed, with Q-factors exceeding 2x10 3 for a single microsphere. Research on the functionality and performance of different fiber/microsphere combinations focuses on the material and size of the microspheres as key parameters for the optimization of the corresponding spectral patterns and Q-factors. This newly developed resonating system constitutes an optical platform with various potential applications.